Pharmacologically Active Phytomolecules Isolated from Traditional Antidiabetic Plants and Their Therapeutic Role for the Management of Diabetes Mellitus

Abstract

Diabetes mellitus is a chronic complication that affects people of all ages. The increased prevalence of diabetes worldwide has led to the development of several synthetic drugs to tackle this health problem. Such drugs, although effective as antihyperglycemic agents, are accompanied by various side effects, costly, and inaccessible to the majority of people living in underdeveloped countries. Medicinal plants have been used traditionally throughout the ages to treat various ailments due to their availability and safe nature. Medicinal plants are a rich source of phytochemicals that possess several health benefits. As diabetes continues to become prevalent, health care practitioners are considering plant-based medicines as a potential source of antidiabetic drugs due to their high potency and fewer side effects. To better understand the mechanism of action of medicinal plants, their active phytoconstituents are being isolated and investigated thoroughly. In this review article, we have focused on pharmacologically active phytomolecules isolated from medicinal plants presenting antidiabetic activity and the role they play in the treatment and management of diabetes. These natural compounds may represent as good candidates for a novel therapeutic approach and/or effective and alternative therapies for diabetes.

The Effect Of Giving Okra Fruit-Infused Water On Recreasing Cholesterol Levels In Hypercholesterolemia Patients In Payan Pabean Sidoarjo Village

“…Okra fruit can be used as a material that can lower No cholesterol, yet known by some big societies. The study is supported by (Ansari et al, 2022), who stated the effect of okra mucilage ( crude water extract and fractions ) with a dose of raw water extract of okra (500 and 100 mg/kg BW) or water fraction (50 and 100 mg/ kgBB ) given with a highfat diet rat hypercholesterolemia During one week. Showing results show that water extract and water fraction of okra fruit modulate blood fat levels and have potency for use as veggie friendly _ Heart ".…”

Analysis of the Bioactive Compounds from Carica papaya in the Management of Psoriasis using Computational Techniques

“…In the research and development of new drugs, phytochemicals are rapidly emerging as significant alternative medicinal and pharmacological agents. As opposed to synthetic medications, they have fewer or no adverse effects after administration, a unique mode of action, and a wide range of chemical constituents, all of which improve their therapeutic interaction with a variety of biological targets [14]. Phytochemicals derived from papayas such as flavonoids, terpenoids, tannins, and phenols have been found to have anti-psoriatic and antiinflammatory effects associated with psoriasis [15].…”

Polyphenol-Rich Leaf of Annona squamosa Stimulates Insulin Release from BRIN-BD11 Cells and Isolated Mouse Islets, Reduces (CH2O)n Digestion and Absorption, and Improves Glucose Tolerance and GLP-1 (7-36) Levels in High-Fat-Fed Rats

“…Thus, extensive research is being conducted on plant- and animal-based resources to develop alternative medicines for the treatment and management of this global epidemic. Due to their multiple health benefits, medicinal plants have been traditionally used to treat diseases in local communities since ancient times [ 17 ]. To date, over 800 plant species have been identified as having anti-diabetic properties [ 18 ].…”

“…To date, over 800 plant species have been identified as having anti-diabetic properties [ 18 ]. Alkaloids, polyphenols, tannins, flavonoids, and other phytochemicals are among the many phytoconstituents found in these plants that are highly potent and effective in lowering blood glucose, and thus may help in the discovery and development of newer drugs to combat T2DM [ 17 , 19 ].…”