2024
DOI: 10.1002/psp4.13271
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Pharmacometric and statistical considerations for dose optimization

Palang Chotsiri,
Prasert Yodsawat,
Richard M. Hoglund
et al.

Abstract: The probability of target attainment (PTA) is a common metric in drug dose optimization, but it requires a specific known target concentration threshold. Such target thresholds are not always available for some treatments, and patient and disease groups, particularly when treating children. This study performed pharmacokinetic and pharmacokinetic‐pharmacodynamic (PKPD) simulations to explore different statistical approaches for determining the optimal dose for unknown PK and PKPD targets. To determine an optim… Show more

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