Pharmacotechnical Development and Optimization of Multilayered Tablets: An Updated Industrial Review With Emphasis on Bilayer Tablets

Agiba, Ahmed M.; Abul-Ella, Soha Sayed; El-Monem, Rehab A Abd

doi:10.22159/ijap.2021v13i4.41528

Cited by 3 publications

(1 citation statement)

References 64 publications

(107 reference statements)

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“…Bilayered layers comprising floating systems are intended to aid in the formulation's retention in the stomach and are particularly effective for insoluble or unstable medications in intestinal fluids. Floating drug delivery systems float in the stomach and release the drug at a controlled rate over an extended period of time11 .…”

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A Review on Applications of Bilayer Tablet Technology for Drug Combinations

Soni¹,

Joshi²,

Jain³

et al. 2022

J. Drug Delivery Ther.

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Bilayer tablets are novel drug delivery systems where combination of two drugs in a single unit having different release profiles can be delivered. Bilayer tablets improve patient compliance, prolong the drug(s) action and can deliver two incompatible drugs in a single formulation. Bilayer tablets have one layer of active ingredient for immediate release and a second layer for delayed release, either as a second dose or in an extended release fashion. Bilayer tablets are advancing helpful technologies to overcome the disadvantages of single-layered tablets. However, bilayer tablet technology is resource-intensive. A thorough selection of excipients and manufacturing conditions for each technical stage is also required. Patients with high blood pressure often have difficulty or are unable to regulate their BP with just a single medication. The majority of hypertension patients will need to take two or more antihypertensive medicines in order to meet treatment goals. Combinations of antihypertensive drugs from various categories have been found to be more effective than either drug alone in treating hypertension in people whose blood pressure cannot be maintained satisfactorily with monotherapy. Combining two antihypertensive medications with mutually beneficial mechanisms of action may result in much greater blood pressure lowering efficacy than any of these components alone. The goal of this review is to discuss the use of bilayer tablets to administer fixed antihypertensive drug combinations for the treatment of high blood pressure. Keywords: Bilayer tablet, blood pressure, antihypertensive drugs, Sustained release, maintenance dose.

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confidence: 99%

A Review on Applications of Bilayer Tablet Technology for Drug Combinations

Soni¹,

Joshi²,

Jain³

et al. 2022

J. Drug Delivery Ther.

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Quality by Design (QbD) Concept for Formulation of Oral Formulations for Tablets

Ansari,

Alahmed,

Sami

2024

Introduction to Quality by Design (QbD)

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Advances in Light-Responsive Smart Multifunctional Nanofibers: Implications for Targeted Drug Delivery and Cancer Therapy

Agiba,

Elsayyad,

ElShagea

et al. 2024

Pharmaceutics

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Over the last decade, scientists have shifted their focus to the development of smart carriers for the delivery of chemotherapeutics in order to overcome the problems associated with traditional chemotherapy, such as poor aqueous solubility and bioavailability, low selectivity and targeting specificity, off-target drug side effects, and damage to surrounding healthy tissues. Nanofiber-based drug delivery systems have recently emerged as a promising drug delivery system in cancer therapy owing to their unique structural and functional properties, including tunable interconnected porosity, a high surface-to-volume ratio associated with high entrapment efficiency and drug loading capacity, and high mass transport properties, which allow for controlled and targeted drug delivery. In addition, they are biocompatible, biodegradable, and capable of surface functionalization, allowing for target-specific delivery and drug release. One of the most common fiber production methods is electrospinning, even though the relatively two-dimensional (2D) tightly packed fiber structures and low production rates have limited its performance. Forcespinning is an alternative spinning technology that generates high-throughput, continuous polymeric nanofibers with 3D structures. Unlike electrospinning, forcespinning generates fibers by centrifugal forces rather than electrostatic forces, resulting in significantly higher fiber production. The functionalization of nanocarriers on nanofibers can result in smart nanofibers with anticancer capabilities that can be activated by external stimuli, such as light. This review addresses current trends and potential applications of light-responsive and dual-stimuli-responsive electro- and forcespun smart nanofibers in cancer therapy, with a particular emphasis on functionalizing nanofiber surfaces and developing nano-in-nanofiber emerging delivery systems for dual-controlled drug release and high-precision tumor targeting. In addition, the progress and prospective diagnostic and therapeutic applications of light-responsive and dual-stimuli-responsive smart nanofibers are discussed in the context of combination cancer therapy.

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Pharmacotechnical Development and Optimization of Multilayered Tablets: An Updated Industrial Review With Emphasis on Bilayer Tablets

Cited by 3 publications

References 64 publications

A Review on Applications of Bilayer Tablet Technology for Drug Combinations

A Review on Applications of Bilayer Tablet Technology for Drug Combinations

Quality by Design (QbD) Concept for Formulation of Oral Formulations for Tablets

Advances in Light-Responsive Smart Multifunctional Nanofibers: Implications for Targeted Drug Delivery and Cancer Therapy

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