pharmaHUB: Building a Virtual Organization for Pharmaceutical Engineering and Science

Kuriyan, Kamal; Catlin, Ann Christine; Reklaitis, Gintaras V.

doi:10.1007/s12247-009-9061-7

Cited by 10 publications

(5 citation statements)

References 19 publications

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“…HUBzero is an open source software platform for creating dynamic, programmable websites that allows users worldwide to deploy research tools, disseminate scientific resources, and distribute educational modules (Hacker et al, 2011 ; McLennan & Kennell, 2010 ). Hub technology supports customizable solutions for data collection, exploration, and analytics (Huang et al, 2014 ; Kuriyan, Catlin, & Reklaitis, 2009 ; Wang et al, 2013 ).…”

Section: Methodsmentioning

confidence: 99%

Sankofa pediatric HIV disclosure intervention cyber data management: building capacity in a resource-limited setting and ensuring data quality

et al. 2015

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Prevalence of pediatric HIV disclosure is low in resource-limited settings. Innovative, culturally sensitive, and patient-centered disclosure approaches are needed. Conducting such studies in resource-limited settings is not trivial considering the challenges of capturing, cleaning, and storing clinical research data. To overcome some of these challenges, the Sankofa pediatric disclosure intervention adopted an interactive cyber infrastructure for data capture and analysis. The Sankofa Project database system is built on the HUBzero cyber infrastructure (https://hubzero.org), an open source software platform. The hub database components support: (1) data management – the “databases” component creates, configures, and manages database access, backup, repositories, applications, and access control; (2) data collection – the “forms” component is used to build customized web case report forms that incorporate common data elements and include tailored form submit processing to handle error checking, data validation, and data linkage as the data are stored to the database; and (3) data exploration – the “dataviewer” component provides powerful methods for users to view, search, sort, navigate, explore, map, graph, visualize, aggregate, drill-down, compute, and export data from the database. The Sankofa cyber data management tool supports a user-friendly, secure, and systematic collection of all data. We have screened more than 400 child–caregiver dyads and enrolled nearly 300 dyads, with tens of thousands of data elements. The dataviews have successfully supported all data exploration and analysis needs of the Sankofa Project. Moreover, the ability of the sites to query and view data summaries has proven to be an incentive for collecting complete and accurate data. The data system has all the desirable attributes of an electronic data capture tool. It also provides an added advantage of building data management capacity in resource-limited settings due to its innovative data query and summary views and availability of real-time support by the data management team.

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Section: Methodsmentioning

confidence: 99%

Sankofa pediatric HIV disclosure intervention cyber data management: building capacity in a resource-limited setting and ensuring data quality

et al. 2015

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“…Externalization can be achieved through the use of web technologies (e.g. corporate portals) aiming to the establishment of virtual organizations.Pharmaceutical factory monitoring system based on Ethernet (28), virtual organizations for pharmaceutical engineering and science (29) Collaboration Community participation applications like groupware, collaborative project management software and electronic conferencing tools, used for accessing to a firm’s external knowledge or facilitating research partnerships.Communities and collaboration in discovery and development (30), collaborative drug discovery (31) Document management systems This tools are found in the interface between storage and dissemination, they locate documents inside a clear management police and keep track of their status and versions.Modern document management in the regulatory context (32), electronic document management (33)Support KM frameworks An organized set of ideas, principles, information, rules and definitions that configure the structure of a knowledge management initiative.Frameworks in process KM (4), a framework for knowledge-based diagnostic systems in batch chemical processes (34) KM models A theoretical representation of the desired or actual state of a system, making special emphasis on the knowledge actors, flows, constrains and relationshipsProcess model for knowledge management in plant maintenance (35), structural model of knowledge management across borders (36) KM strategies Plan or direction to achieve the goals of knowledge management so it can react to uncertain environments.Strategies for drug knowledge transfer process in pharmaceutical marketing (37), strategies to manage knowledge flows between high-tech firms and universities (38) KM indicators Figures that represent the level of success for a given knowledge management activity, aiming to assess its performance in concordance with a stated goal in the KM strategyMeasurement scale for knowledge management in biotechnology (39), Structural influence index in KM (40) …”

Section: Introductionmentioning

confidence: 99%

Role of Knowledge Management in Development and Lifecycle Management of Biopharmaceuticals

et al. 2016

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Knowledge Management (KM) is a key enabler for achieving quality in a lifecycle approach for production of biopharmaceuticals. Due to the important role that it plays towards successful implementation of Quality by Design (QbD), an analysis of KM solutions is needed. This work provides a comprehensive review of the interface between KM and QbD-driven biopharmaceutical production systems as perceived by academic as well as industrial viewpoints. A comprehensive set of 356 publications addressing the applications of KM tools to QbD-related tasks were screened and a query to gather industrial inputs from 17 major biopharmaceutical organizations was performed. Three KM tool classes were identified as having high relevance for biopharmaceutical production systems and have been further explored: knowledge indicators, ontologies, and process modeling. A proposed categorization of 16 distinct KM tool classes allowed for the identification of holistic technologies supporting QbD. In addition, the classification allowed for addressing the disparity between industrial and academic expectations regarding the application of KM methodologies. This is a first of a kind attempt and thus we think that this paper would be of considerable interest to those in academia and industry that are engaged in accelerating development and commercialization of biopharmaceuticals.Electronic supplementary materialThe online version of this article (doi:10.1007/s11095-016-2043-9) contains supplementary material, which is available to authorized users.

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“…While many existing hubs focus on community building, with an interest in sharing data and pedagogical materials [10], many of our users need to protect industry trade secrets and are anxious about data or source code leaving their internal systems. This prompted us to provide a robust security infrastructure and user support tools.…”

Section: Introductionmentioning

confidence: 99%

Collaborative research in a regional grid

Neeman

Gallo

Efstathiadis

2010

2010 Gateway Computing Environments Workshop (GCE)

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Research teams collaborating across institutional, geographical and cultural boundaries are increasingly common. Funding agencies including the National Science Foundation (NSF) and National Institutes of Health (NIH) strongly encourage virtual organization building and collaboration across institutions and disciplines. A set of software tools that enables scientists to efficiently share information and resources with distributed collaborators is key to facilitate collaboration of research teams across institutional and geographical boundaries. Utilizing HUBzero, we have implemented a regional infrastructure supporting the High Performance Computing Consortium (HPC2) initiative within New York State. This hub consists of a web-portal infrastructure that allows investigators and research groups to easily create and share research materials as well as computational and storage resources among their members. In this paper, we describe the process of launching the hub and providing access to a regional grid consisting of three supercomputing sites with heterogeneous computing platforms and security/access policies. We address issues of capacity and security that arose as we road-tested this evolving platform.

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pharmaHUB: Building a Virtual Organization for Pharmaceutical Engineering and Science

Cited by 10 publications

References 19 publications

Sankofa pediatric HIV disclosure intervention cyber data management: building capacity in a resource-limited setting and ensuring data quality

Sankofa pediatric HIV disclosure intervention cyber data management: building capacity in a resource-limited setting and ensuring data quality

Role of Knowledge Management in Development and Lifecycle Management of Biopharmaceuticals

Collaborative research in a regional grid

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