Pharyngeal and peritonsillar abscess due to Leclercia adecarboxylata in an immunocompetant patient

Bali, Rishi; Sharma, Parveen; Gupta, Kamini; Nagrath, Saurabh

doi:10.3855/jidc.2651

Cited by 23 publications

(12 citation statements)

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“…The organism has been reported as an opportunistic pathogen in immunocompromised hosts and in polymicrobial infections in immunocompetent hosts, which suggests the dependence of this micro‐organism on co‐flora to cause a disease (Bali et al . ). This led to the suggestion by some authors that it is exclusively an opportunistic pathogen in humans.…”

Section: Resultsmentioning

confidence: 97%

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Isolation and characterization of multidrug-resistant Leclercia species from animal clinical case

Choudhary

Bhoyar

et al. 2017

Lett Appl Microbiol

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Significance and Impact of the Study: Leclercia adecarboxylata is a rarely reported human pathogen. We report here the case from bovine suffering from respiratory distress; the sample yielded Leclercia species as polymicrobial culture. The isolate was found to be multidrug resistant and evidenced for uncertain clinical relevance and could act as hidden source of public health hazard. The limited literature available on this organism is reviewed, and the potential implications of findings are discussed. To the best of our knowledge, this is the first report of isolation and characterization of multidrug-resistant Leclercia species from animal clinical case from India. AbstractLeclercia adecarboxylata, a Gram-negative bacillus of family Enterobacteriaceae, is an uncommonly identified pathogen isolated from environmental and clinical specimens. Most of the human infections are polymicrobial and commonly occur in immunocompromised hosts, although nosocomial infections in immunocompetent hosts have been documented. Here, we describe the case of isolation of Leclercia species as polymicrobial infection from bovine suffering from respiratory distress in Chhattisgarh state of India. The isolates were identified by their phenotypes, 16S rDNA sequencing and MALDI-TOF-MS. The isolate was found to be resistant to aminoglycosides and fluoroquinolone antibiotics and intermediate resistant to cephalosporins and evidenced for uncertain clinical relevance and could act as hidden source of public health hazard.

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Section: Resultsmentioning

confidence: 97%

“…The organism is considered as an opportunistic agent (Bali et al . ). The first detection of MDR plasmids and determination of their complete sequences in L. adecarboxylata recovered from a clinical case from China was reported (Sun et al .…”

Section: Introductionmentioning

confidence: 97%

Isolation and characterization of multidrug-resistant Leclercia species from animal clinical case

Choudhary

Bhoyar

et al. 2017

Lett Appl Microbiol

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“…Se ha asociado con brotes nosocomiales de artritis y bacteriemia en pacientes inmunocompetentes, aunque esta situación es rara. 2,4,5 Afecta, generalmente, a sujetos con cierto grado de inmunosupresión como agente oportunista y en el contexto de infecciones polimicrobianas, 8 al igual que en nuestro paciente, con coinfección con C. parasilopsis. Del mismo modo, las infecciones por R. ornithinolytica se han descrito en diabéticos, pacientes oncológicos 9,10 e inmunodeprimidos.…”

Section: Discussionunclassified

Infección asociada a catéter por Leclercia adecarboxylata y Raoultella ornithinolytica en un paciente con enfermedad mitocondrial

et al. 2019

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RESUMENLeclercia adecarboxylata y Raoultella ornithinolytica constituyen bacterias Gram-negativas emergentes. Los casos descritos son excepcionales. En los últimos años, las mejoras en las técnicas de diagnóstico microbiológico han permitido su detección y conocimiento. Se presenta el caso de un niño de 11 años con enfermedad mitocondrial, portador de catéter venoso central de larga duración, que desarrolló dos episodios de sepsis por L. adecarboxylata y R. ornithinolytica, respectivamente. En los casos de infección asociada al uso de catéter, es posible, en ocasiones, el tratamiento sin su retirada con evolución favorable. Es importante reconocer L. adecarboxylata y R. ornithinolytica como patógenos de diagnóstico cada vez más frecuentes, sobre todo, en pacientes inmunodeprimidos o con patologías crónicas asociadas. Palabras clave: sepsis, Enterobacteriaceae, infecciones relacionadas con catéteres, enfermedades mitocondriales, pediatría.ABSTRACT Leclercia adecarboxylata and Raoultella ornithinolytica are emergent Gram-negative bacteria. Infections caused by these microorganisms are exceptional. Improvement of microbiologist techniques in the last years has enabled their detection and more accurate knowledge. We present the case of an 11-year-old boy with mitochondrial disease with a longterm central catheter who suffered from two sepsis caused by L. adecarboxylata and R. ornithinolytica, respectively. In catheter-related infections, sometimes it is possible to provide antimicrobial treatment without removal of catheter with good results, as in our patient. It is important to recognize L. adecarboxylata and R. ornithinolytica like increasingly frequent pathogenic bacteria, mostly in immunocompromised or chronic patients.

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“…Ayrıca malignensi olan hastalarda santral venöz kateter ilişkili bakteriyemi bildirilmiştir 13 . Bunlardan başka farklı çalışmalarda pnömoni, septik artrit, pyelonefrit, farengeal ve peritonsiller abse, endokardit, osteomyelit etkeni olarak izole edildiği de bildirilmiştir [14][15][16][17][18][19] .…”

Section: Olgu Sunumuunclassified

Catheter-Related Bacteremia Caused By Leclercia adecarboxylata: Case Report

Şafak¹,

Sezer²,

Yenigun³

2017

BSBD

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bsbd@balikesir.edu.tr www.bau-sbdergisi.com ÖZET Öncel eri Enteri k grup 41 veya Eschrechia adecarboxylata ol a ra k bi l i nen mi kroorga ni zma , 1962'den i tibaren Leclercia adecarboxylata ol arak adlandırılmıştır. Çeşitli çevresel kaynaklarda bul unan mikroorganizmanın kan, idrar, balgam, ya ra gibi farklı klinik örneklerden i zole edil di ği bi l dirilmiştir. Bu olgu, bilgilerimize göre ül kemi zden bi l di ri l en L. adecarboxylata'ya ba ğl ı i l k enfeks i yon ol ma s ı nedeni yl e s unul muştur.Son dönem kroni k böbrek yetmezl i ği ol a n di ya l i ze gi ren 85 ya şında ki erkek ha s ta , a teş şi ka yetiyle acil servi se başvurmuştur. La boratuva r tetkiklerinde beya z küre normal, CRP, üre ve krea tinin yüksek olarak ölçülmüştür. Ya tırılarak tedavisi planlanan hastadan kateter ve peri fer da mar yol undan kan kültürü alınmıştır. Ampirik olarak s eftri a ks on teda vi s i ne ba şl a nmıştır. Ka teterden alınan kan kültürü, perifer damar yol undan alınan kan kültüründen dört s a a t önce ol mak üzere her iki örnekten de BacT/Alert 3D (bioMerieux, Fransa) kan kültür ci hazında pozitif s i nyal alınmıştır. L. adecarboxylata ol arak tanımlanan bakteri a mikasin, gentamisin, s eftazidim, s eftriakson, siprofloksasin, i mipenem duya rl ı, a moks i s i l i n -kl a vul a ni k a s i t di rençl i ol a ra k bul unmuştur. Ka teterden alınan kan kültürü örneği dört s aat önce pozitiflik verdiğinden kateter i l i şki l i L. adecarboxylata'ya ba ğl ı ba kteri yemi ta nıs ı konul muştur. Anti bi yoti k duya rl ıl ık ra poruna göre s eftri a ks on duya rl ı bul unduğunda n teda vi 15 güne ta ma ml a nmıştır.E. coli'ye benzerliği nedeniyle s ıklıkla a tlanabileceğinden özel l i kl e fos fomi s i n di rençl i E. coli i zolatlarında, ileri biyokimyasa l a na l i zl erl e a yrımının ya pıl ma s ı gerekti ği düşünül müştür.Anahtar Kelimeler: Lecl erci a a deca rboxyl a ta , ka teter ka yna kl ı, ba kteri yemi SUMMARYThe mi croorganism known as Enteri c group 41 or Escherichia adecarboxylatain the pa s t wa s na med as Leclercia adecarboxylata s i nce 1962. It has been reported that the mi croorga ni s m, whi ch is present i n va rious environmenta l res ources wa s i s ol a ted from di fferent cl i ni ca l s pecimens s uch a s blood, urine, sputum and wound. This case report was presented, beca us e of the fa ct that i t is the first reported infection caused by L. adecarboxylata i n our country a s fa r a s we know.The ma le patient aged 85 yea rs old on di a l ys i s wi th end s ta ge chroni c rena l di s ea s e wa s a dmitted to emergency s ervice wi th complaint of fever. The laboratory a nalysis revealed hi gh l evels of CRP, urea a nd creatinin and normal levels of white blood cel l count. Bl ood cul tures were obtained vi a the catheter and periphera l va s cul a r a cces s , from the pa ti ent who wa s hos pitalised to plan the treatment. Ceftriaxone was s tarted as a n empi ri ca l trea tment. Both bl ood culture s amples were positive signalling i n Bact/Alert 3D (Biomeriuex, Fra nce) i n whi ch the one obtained f...

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Pharyngeal and peritonsillar abscess due to Leclercia adecarboxylata in an immunocompetant patient

Abstract: Leclercia adecarboxylata was isolated in pure culture from a peritonsillar and lateral pharyngeal abscess in an immunocompetent host. To our knowledge, this is the first case of infection caused by this microorganism being found in an odontogenic area of the head and neck.

Cited by 23 publications

References 14 publications

Isolation and characterization of multidrug-resistant Leclercia species from animal clinical case

Isolation and characterization of multidrug-resistant Leclercia species from animal clinical case

Infección asociada a catéter por Leclercia adecarboxylata y Raoultella ornithinolytica en un paciente con enfermedad mitocondrial

Catheter-Related Bacteremia Caused By Leclercia adecarboxylata: Case Report

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