Phase behavior, in vitro drug release, and antibacterial activity of thermoresponsive <scp>poloxamer–</scp>polyvinyl alcohol hydrogel‐loaded mupirocin nanoparticles

Kamlungmak, Sukanjana; Rugmai, Supagorn; Tinpun, Kittiya; Nakpheng, Titpawan; Srichana, Teerapol

doi:10.1002/app.49325

Cited by 17 publications

(13 citation statements)

References 24 publications

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“…This approach can be utilized to provide the sustained release of sparingly soluble drugs. A thermoresponsive poloxamer (P407)-polyvinyl alcohol gel was developed to deliver mupirocin nanoparticles for wound healing [ 27 ]. Silver sulfadiazine/nanosuspensions (AgSD/NS) were prepared and loaded into poloxamer 407-based TGs as carriers of AgSD/NS to obtain AgSD/NS-loaded TGs [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the establishment of an appropriate drug release model, through the fitting of the experimental data, was an effective means to simulate and predict the release behavior of MXD-TG. It was reported that the hydrogel-loaded mupirocin nanoparticles fitted the first-order kinetics, which showed that the drug release was controlled mainly by diffusion [ 27 ]. Differently, the gemcitabine release of high-molecular-weight hyaluronic-acid-added gel was diffusion-erosion controlled [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

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Poloxamer 407/188 Binary Thermosensitive Gel as a Moxidectin Delivery System: In Vitro Release and In Vivo Evaluation

Ruan

et al. 2022

Molecules

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Moxidectin (MXD) is an antiparasitic drug used extensively in veterinary clinics. In this study, to develop a new formulation of MXD, a thermosensitive gel of MXD (MXD-TG) was prepared based on poloxamer 407/188. Furthermore, the gelation temperature, the stability, in vitro release kinetics and in vivo pharmacokinetics of MXD-TG were evaluated. The results showed that the gelation temperature was approximately 27 °C. MXD-TG was physically stable and can be released continuously for more than 96 h in vitro. The Korsmeyer–Peppas model provided the best fit to the release kinetics, and the release mechanism followed a diffusive erosion style. MXD-TG was released persistently for over 70 days in sheep. Part of pharmacokinetic parameters had a difference in female and male sheep (p < 0.05). It was concluded that MXD-TG had a good stability, and its release followed the characteristics of a diffusive erosion style in vitro and a sustained release pattern in vivo.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Poloxamer 407/188 Binary Thermosensitive Gel as a Moxidectin Delivery System: In Vitro Release and In Vivo Evaluation

Ruan

et al. 2022

Molecules

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“…This was interpreted as there is no chemical bond interaction between the molecules of the mupirocin and the molecules of the carriers and that the mupirocin is surrounded by the molecules of the carrier. 219 Gu ¨ven and Yenilmez produced Kollidon SR NPs containing antiallergic olopatadine hydrochloride with a nano spray dryer. 176 NMR analysis was performed on pure olopatadine hydrochloride, Kollidon SR physical mixture, and drugloaded NPs.…”

Section: Nmr Analysismentioning

confidence: 99%

Nano Spray-Dried Drugs for Oral Administration: A Review

Öztürk

Arpagaus

2021

ASSAY and Drug Development Technologies

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Spray drying is an important technology that is fast, simple, reproducible, and scalable. It has a wide application range, that is, in food, chemicals, and encapsulation of pharmaceuticals. The technology can be divided into conventional spray drying and nano spray drying. The key advantage of nano spray drying is the production of drug-loaded nanosized particles for various drug delivery applications. The recent developments in nano spray dryer technology and the market launch of the Nano Spray Dryer B-90 by Bu ¨chi Labortechnik AG in 2009 enabled the production of submicron spray-dried particles. This review focuses on nanosized drug delivery systems intended for oral administration produced by nano spray drying. First, the nano spray drying concept, the basic technologies implemented in the equipment, and the effects of the various process parameters on the final dry submicron powder properties are presented. Then, the topics of new formulation strategies of oral drugs are highlighted with examples that have entered the research literature in recent years. Next, the subjects of direct conversion of poorly watersoluble drugs, encapsulation of drugs, and drying of preformed nanoparticles are considered. Finally, topics such as morphology, particle size, size distribution, surface analysis, bioavailability, drug release, release kinetics, and solid-state characterization (by differential scanning calorimetry, X-ray diffraction, Fourier transform infrared spectroscopy, nuclear magnetic resonance) of oral drug delivery systems produced by nano spray drying are discussed. The review attempts to provide a comprehensive knowledge base with current literature and foresight to researchers working in the field of pharmaceutical technology and nanotechnology and especially in the field of nano spray drying.

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“…In contrast to MUP, MLH exhibited a progressive controlled drug release ointment due to the cubic phase behavior of thermosensitive polymer and PVA hydrogel. The MLH exhibited reduced MIC and minimum bactericidal concentrations against S. aureus, S. epidermidis, Pseudomonas aeruginosa, and E. coli compared to the MUP ointment [57]. Recently, the same group studied the biocompatibility and safety of MLH for wound healing in the rat model.…”

Section: Nanoparticles/naocapsulesmentioning

confidence: 99%

Recent Advances in Mupirocin Delivery Strategies for the Treatment of Bacterial Skin and Soft Tissue Infection

Gangwar

Kumar²,

Singh

et al. 2021

Future Pharmacology

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Skin and soft tissue infections (SSTIs) have increased problematically in hospital and ambulatory settings due to the poor immunity of hosts and multidrug-resistant pathogens. Mupirocin (MUP), a global topical antibiotic, is used for the treatment of SSTIs caused by various pathogens due to its unique mechanism of action. However, the therapeutic efficiency of MUP is hampered due to the protein binding and drug resistance caused by frequent use. A combined report covering the various aspects of MUP, such as the synthesis of the novel formulation, loading of the drug, and application against various skin infections, is missing. This comprehensive review focuses on various novel drug delivery strategies such as composite biomaterials/scaffold, hydrogel dressings, liposomes, liposomal hydrogel, microparticles/microspheres, microsponges, nanocapsules, nanofibers, silicone-based adhesive patches, and topical sprays. The therapeutic effect of the MUP can be synergized by combining with other agents and using novel strategies. The objective is to enhance patient compliance, decrease the resistance, magnify the delivery of MUP, and overcome the limitations of conventional formulations. Moreover, the carriers/dressing materials are biocompatible, biodegradable, stimulate wound healing, protect the wound from external environmental contamination, adsorb the wound exudates, and are permeable to oxygen and moisture. This review will help researchers to explore further the treatment of various bacterial skin infections by using MUP-loaded novel formulations with better efficacy, utilizing the novel nanostructures or combinatorial methods.

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Phase behavior, in vitro drug release, and antibacterial activity of thermoresponsive poloxamer–polyvinyl alcohol hydrogel‐loaded mupirocin nanoparticles

Cited by 17 publications

References 24 publications

Poloxamer 407/188 Binary Thermosensitive Gel as a Moxidectin Delivery System: In Vitro Release and In Vivo Evaluation

Poloxamer 407/188 Binary Thermosensitive Gel as a Moxidectin Delivery System: In Vitro Release and In Vivo Evaluation

Nano Spray-Dried Drugs for Oral Administration: A Review

Recent Advances in Mupirocin Delivery Strategies for the Treatment of Bacterial Skin and Soft Tissue Infection

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