Phase behavior of binary mixtures of block copolymers and a non-solvent in miniemulsion droplets as single and double nanoconfinement

Staff, Roland H.; Rupper, Patrick; Lieberwirth, Ingo; Landfester, Katharina; Crespy, Daniel

doi:10.1039/c1sm05988b

Cited by 58 publications

(79 citation statements)

References 46 publications

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“…The diameter of the particle is in this case also very important. Indeed, if the particle size is low enough, core-shell or Janus structures can be obtained [40]. A large variety of different structures were predicted from simulations on diblock copolymer/homopolymer blends [63], startriblock copolymers in spherical nanopores [64], or on diblock copolymers under different confinements [65][66][67], among which several have already been prepared 336 R.H. Staff et al by the emulsion-solvent evaporation process.…”

Section: Colloidal Structuresmentioning

confidence: 98%

“…Additionally, both the evaporation temperature and the evaporation rate of the solvent are of high importance for the build-up of a thermodynamically stable morphology [36,37,69]. However, structures that resemble kinetically trapped morphologies can also be thermodynamically stable when specific ratios of block length in the block copolymers are achieved [23] or if the phase separation occurs in the weak segregation limit [40]. Both cases were used for the generation of patchy nanoparticles and nanocapsules.…”

Section: Colloidal Structuresmentioning

confidence: 98%

“…Because the particles are formed from droplets, their size is largely dependent on the droplet size. In the case of miniemulsions, the size of the droplets is controlled by the concentration of surfactant [40]. Other parameters such as the nature of the solvent [46], the stirring rate, or ultrasonication time [47] also influence the particle size and particle size distribution.…”

Section: Mechanism Of the Emulsion-solvent Evaporation Processmentioning

confidence: 99%

“…Half-spherical structures are accessible by removing the liquid in acorn structures formed with a polymer and a liquid [40,61]. Onion-like structures are created from block copolymers, for which the phase separation into lamellae causes layered structures that follows the curvature of the particle where they are confined [37,40,62].…”

Section: Colloidal Structuresmentioning

confidence: 99%

“…2) [31]. The use of different polymer mixtures or architectures such as polymer blends [19,[33][34][35], statistical copolymers [32], and block copolymers [23,[36][37][38][39][40] is possible. The latter polymer architecture is especially interesting for introducing an additional spatial segregation in nanoparticles to yield new multicompartment structures, such as nanocapsules or polymer particles with two or more phases, which are discussed in more detail below.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Recent Advances in the Emulsion Solvent Evaporation Technique for the Preparation of Nanoparticles and Nanocapsules

Staff

Landfester

Crespy

2013

Hierarchical Macromolecular Structures: 60 Years After the Staudinger Nobel Prize II

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The emulsion solvent evaporation technique is a method for preparing nanoparticles and nanocapsules that are particularly adapted for applications requiring materials with high purity and low toxicity, such as for biomedicine or electronics. We discuss here new important advances concerning the elucidation of the mechanism of nanoparticle formation, and the synthesis of nanoparticles with new structures or from new polymers.

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Section: Colloidal Structuresmentioning

confidence: 98%

Section: Colloidal Structuresmentioning

confidence: 98%

Section: Mechanism Of the Emulsion-solvent Evaporation Processmentioning

confidence: 99%

Section: Colloidal Structuresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Recent Advances in the Emulsion Solvent Evaporation Technique for the Preparation of Nanoparticles and Nanocapsules

Staff

Landfester

Crespy

2013

Hierarchical Macromolecular Structures: 60 Years After the Staudinger Nobel Prize II

Self Cite

View full text Add to dashboard Cite

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Multidimensional Design of Anisotropic Polymer Particles from Solvent‐Evaporative Emulsion

Shin

Yun

et al. 2018

Adv Funct Materials

157

177

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Colloidal particles with controlled shape and internal structure have attracted great attention due to their novel morphologies and various potential applications. Among the diverse synthetic strategies toward anisotropically shaped polymer particles, facile and accurate engineering of such structures remains challenging. This review highlights the synthetic approaches to manipulate the shape of polymer particles driven by phase separation in emulsions upon solvent evaporation. And, special attention is given to the thermodynamic and kinetic principles of particle shape control, followed by detailed experimental examples and their applications. Major synthetic strategies for the preparation of nonspherical block copolymer (BCP) particles by evaporation of solvent from BCP‐containing emulsions are discussed as follows: engineering of i) interfacial properties of the confining emulsion droplets, ii) particle (or droplet) size, iii) segregation behavior of BCPs within the droplet, and iv) solvent‐induced BCP self‐assembly kinetics (i.e., solvent evaporation rate). Next, functionalized BCP particles produced by careful design of the chemical structures of polymer or by incorporation of functional additives into the polymer matrix are introduced. Finally, this review article aims to present the challenging issues associated with current methods and future directions for research in this field.

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Block Copolymer Capsules with Structure‐Dependent Release Behavior

Yang

et al. 2016

Angewandte Chemie

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Although high-boiling non-solvent induced macrophase separation in emulsion droplets has been widely applied for the fabrication of polymeric capsules,p recise control of their structures remains ag reat challenge.H erein, block copolymer capsules with tunable shell structures were fabricated by employing an on-solvent as al iquid template in emulsion droplets.T he properties of the non-solvents dictate the phase separation sequence in the droplets and the capsule formation mechanism. Tw od ifferent pathwaysf or capsule formation were observed, and could be applied to predict the shell structure.T he structured capsules could be transformed into mesoporous capsules,w hichd emonstrated an intriguing structure-dependent release behavior.C apsules with spherical shell structures displayed the best permeability,w hile those with lamellar shell structures showed the slowest release,b ut with astepwise profile.After loading with an anticancer drug, different capsules induced different apoptosis ratios in cancer cell studies.Polymeric capsules are of great importance to many applications,e specially for protecting loaded cargoes against ah arsh environment and releasing them upon exposure to external triggers. [1][2][3][4] Many approaches, [5][6][7] such as phase separation in emulsion droplets, [8][9][10] sacrificial template guided polymerization, [11,12] layer-by-layer assembly techniques, [13][14][15] self-assembly of block copolymers (BCPs) in selective solvents, [16][17][18][19][20] and others,h ave been introduced for preparing polymeric capsules.A mong these methods,t he macrophase separation of ahigh-boiling non-solvent (HBNS, e.g.,l ong-chain alkanes) in emulsion droplets containing al ow-boiling good solvent (LBGS,e .g., chloroform) and ahomopolymer has been developed as asimple yet versatile strategy for obtaining homopolymer capsules. [21][22][23] However, for BCP capsules,the capsule formation process is much more complicated as microphase separation (between blocks) and macrophase separation (between HBNS and BCPs) occur simultaneously in the droplets.C respy and co-workers recently reported the fabrication of BCP patchy capsules using hexadecane (HD) as the liquid cores. [24][25][26] However,the effect of polymer-solvent interactions on the capsule shell structure needs further exploration. Nowadays,i ti ss till agreat challenge to generate BCP capsules with tunable shell structures in ac ontrolled fashion.Although BCP capsules are robust enough for cargo loading and release,t hey are semipermeable and only allow for very small molecules to be loaded and released owing to the hydrophobic shell. To overcome this disadvantage, capsules with stimuli-responsive shells have been designed as smart nanocarriers to encapsulate functional species and release them in response to external triggers. [27][28][29][30] Furthermore,t ot une the release behavior, [20,[31][32][33][34] capsules with stimuli-responsive mesoporous shells are excellent candidates for controlling the release of payloads. [35][36][37][38] Remar...

show abstract

Phase behavior of binary mixtures of block copolymers and a non-solvent in miniemulsion droplets as single and double nanoconfinement

Cited by 58 publications

References 46 publications

Recent Advances in the Emulsion Solvent Evaporation Technique for the Preparation of Nanoparticles and Nanocapsules

Recent Advances in the Emulsion Solvent Evaporation Technique for the Preparation of Nanoparticles and Nanocapsules

Multidimensional Design of Anisotropic Polymer Particles from Solvent‐Evaporative Emulsion

Block Copolymer Capsules with Structure‐Dependent Release Behavior

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