Phase-Changing Glauber Salt Solution for Medical Applications in the 28–32 °C Interval

Olson, Linus; Lothian, Carina; Ådén, Ulrika; Lagercrantz, Hugo; Robertson, Nicola J.; Setterwall, Fredrik

doi:10.3390/ma14237106

Cited by 11 publications

(8 citation statements)

References 50 publications

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“…Pharmacological research has shown that Glauber's salt strongly stimulates the reticuloendothelial system, enhancing its phagocytic ability and anti-in ammatory effects [12,13]. By stimulating nerve re exes, it increases local blood ow, improves local blood circulation, restores vascular function, quickly reduces temperature and pain, and alleviates swelling [14].…”

Section: Discussionmentioning

confidence: 99%

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Topical application of Glauber’s salt accelerates the absorption of abdominal fluid after pancreatectomy.

Li,

Hua,

Ruan

et al. 2024

Preprint

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Background Abdominal fluid collection (AFC) is one of the most common complications after pancreatic surgery, yet there are few recommendations on how to manage it. Most cases of AFC only require observation, while others may require more invasive techniques. Unfortunately, there are no drugs that effectively promote the absorption of AFCs. The aim of this study was to evaluate the potential efficacy of Glauber's salt solution for promoting the absorption of AFCs after pancreatectomy. Methods This study included 196 patients who underwent pancreatomy and had AFCs on at least 2 cross-sectional follow-up CT images between 2020 and 2022. AFCs were defined as effusion with a diameter ≥ 3 cm and located around the pancreatic resection margin. We retrospectively investigated the relationship between Glauber’s salt concentration and clinical variables. Results The rate of clinically significant pancreatic fistula (grades B + C) was significantly higher in the control group (62.8% vs. 40.7%, P = 0.014). The median maximum diameter of the AFC was smaller, and the median time for the AFC to decrease to 30 mm in diameter was shorter in the Glauber’s salt group than in the control group (41.9 mm vs. 53.5 mm, P = 0.008; 35.5 d vs. 100 d, P < 0.001). According to the multivariate analysis, percutaneous drainage and the application of Glauber’s salt were found to be independent risk factors for AFCs decreasing to less than 30 mm in diameter (HR = 2.338, 95% CI = 1.524–3.585, P < 0.001; HR = 1.853, 95% CI = 1.327–2.589, P < 0.001). Additionally, patients with a maximum postoperative temperature exceeding 38.5°C exhibited enhanced AFC absorption (hazard ratio (HR) = 1.850, 95% CI = 1.268–2.701; P = 0.001). Conclusions Topical application of Glauber's salt solution after pancreatic surgery can promote the absorption of AFCs.

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Section: Discussionmentioning

confidence: 99%

“…In recent decades, Glauber's salt has also been used for treating acute pancreatitis, gastrointestinal disturbances, carbuncles, furuncles, swelling and breast carbuncles [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Topical application of Glauber’s salt accelerates the absorption of abdominal fluid after pancreatectomy.

Li,

Hua,

Ruan

et al. 2024

Preprint

View full text Add to dashboard Cite

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“…1) Non-toxic to the human body, good biocompatibility, [93] ensuring the biocompatibility of PCM and its encapsulation materials is essential to avoid any adverse effects on the human body, thoroughly evaluate the toxicity and potential side effects of PCM-degradable products to ensure patient safety. 2) The phase change temperature should be in close proximity to the human body temperature (37 °C) or within the range of human body tolerance temperature (generally below 45-50 °C).…”

Section: The Advances Of Pcms In the Medical Fieldmentioning

confidence: 99%

Micro/Nano Encapsulated Phase Change Materials: Preparation, Principle, and Emerging Advances in Medical Field

Yuan,

Chen,

Qin

et al. 2024

Adv Funct Materials

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Due to the unique thermal absorption and release capabilities, phase‐change materials (PCMs) are used in various industrial fields, such as photo‐thermal storage and building‐energy saving. In recent years, more and more research has been dedicated to applying PCMs to the medical field with substantial progress, opening new avenues for disease treatment and healthcare. The safety and reliability of PCMs may be taken into serious consider for continuous application in the medical field, while the relevant review on the related development is currently lacking. In this work, the methods for enhancing the applicability and reliability of PCMs in the medical field are systematically summarized, including microencapsulation, electrospinning technology, and porous framework encapsulation, which effectively address the issues of liquid leakage. Subsequently, the emerging advances of PCMs in medical healthcare, including medical dressings treatment, drug delivery, cold chain transport, and bio‐bone cement are summarized. By exploring and analyzing the encapsulation methods, principles as well as the emerging advances of PCMs in medical field, the challenges and perspectives promoting the applications are identified, presenting the guidelines for further development.

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“…Olson et al, (2021) reported the Glauber salt solution is a therapeutically appropriate PCM in the temperature interval required for cooling asphyxiated newborns. [74] PCMs utilized in biological applications often have high latent heat of fusion and low melting temperatures. From the standpoint of melting point and high latent heat of fusion, the FAs acetamide (AC), stearic acid (SA), palmitic acid (PA), myristic acid (MA), capric acid (CA), and lauric acid (LA), are prospective, plentiful, and economical materials for thermal usage.…”

Section: Eutecticmentioning

confidence: 99%

“…Olson et al., (2021) reported the Glauber salt solution is a therapeutically appropriate PCM in the temperature interval required for cooling asphyxiated newborns. [ 74 ]…”

Section: Applications Of Pcms In Life Sciencementioning

confidence: 99%

Phase Change Materials for Life Science Applications

Zare

Mikkonen

2023

Adv Funct Materials

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reported the comparison results in the range of 0-10 based on the equations. The ideal case demonstrates the highest possible level of efficiency, and lifespan, specific power and energy, energy and power density, technical maturity, and the lowest possible power and energy capital cost, self-discharge rate, and environmental impact. [13] Figure 1c represents the PCMs' characteristics.In a previous review, Sadeghi (2022), discussed the thermal energy management of batteries and high-heat-flux electronic devices, and the capability of the TES systems. [2] Costa and Kenisarin (2022) produced a database of metallic PCM's thermophysical features and potential impact in diverse fields, for instance, bioengineering, electronics, solar energy storage, cooling and heating, and beyond. [8] Chavan (2022) covered the recent progress in TES and its usages such as waste heat recovery, solar-based TES, building applications, thermal comfort, heavy electronic equipment cooling, vapor absorption refrigeration (VAR), and Heating, ventilating, and air-conditioning (HVAC) applications. [14] An increasing number of recent research addresses the use of PMCs in human body, detection or sensing, biological, barcoding, drug delivery, and medical applications. However, there is no review comprehensively discussing the life science applications of TES and PMCs materials. Based on our literature survey we concluded that a review of the life science applications of PCMs is a required reference. Besides, the evaluation and safety aspects of TES will be explored in this review. Furthermore, the challenges and recommendations of PCM applications will be addressed in order to assist energy technologists and streamline future research.

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Phase-Changing Glauber Salt Solution for Medical Applications in the 28–32 °C Interval

Cited by 11 publications

References 50 publications

Topical application of Glauber’s salt accelerates the absorption of abdominal fluid after pancreatectomy.

Topical application of Glauber’s salt accelerates the absorption of abdominal fluid after pancreatectomy.

Micro/Nano Encapsulated Phase Change Materials: Preparation, Principle, and Emerging Advances in Medical Field

Phase Change Materials for Life Science Applications

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