2006
DOI: 10.1200/jco.2006.06.4840
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Phase II Trial of Preoperative Chemoradiation in Patients With Localized Gastric Adenocarcinoma (RTOG 9904): Quality of Combined Modality Therapy and Pathologic Response

Abstract: For localized gastric cancer, preoperative chemoradiotherapy strategy achieved a pathCR rate of more than 20% in a cooperative group setting. The quality of surgery improved (50% with D2 dissection) possibly because surgery was part of this trial. With some refinements, this preoperative chemoradiotherapy strategy is poised for a randomized comparison with postoperative adjuvant chemoradiotherapy in patients with gastric cancer.

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Cited by 335 publications
(242 citation statements)
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“…Recently, the results of the new RTOG 9904 phase II trial in patients with localized gastric adenocarcinoma 44 suggest that preoperative CRT followed by surgery after 5-6 weeks caused a substantial pathological response and a longer survival. Surgery, radiotherapy alone or in combination with chemotherapy all play roles in the treatment of gastric carcinoma.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, the results of the new RTOG 9904 phase II trial in patients with localized gastric adenocarcinoma 44 suggest that preoperative CRT followed by surgery after 5-6 weeks caused a substantial pathological response and a longer survival. Surgery, radiotherapy alone or in combination with chemotherapy all play roles in the treatment of gastric carcinoma.…”
Section: Discussionmentioning
confidence: 99%
“…The schedule and doses for these regimens have been published elsewhere. 8,9,10 Typical radiation fields encompassed the stomach and regional lymph nodes employing a multiportal technique with customized blocking that included oblique or lateral fields. Thirty-five percent of patients were treated with use of three-dimensional conformal radiation planning.…”
Section: Treatmentmentioning
confidence: 99%
“…High rates of histological complete response (20-30%) have been reported in the American phase II trials [25], but no randomized study has been conducted to date to address the survival benefit of this modality.…”
Section: Neoadjuvant Chemoradiotherapymentioning
confidence: 99%