Phase II trial on the effects of Silexan in patients with neurasthenia, post-traumatic stress disorder or somatization disorder

Uehleke, Bernhard; Schaper, Selina Johanna; Dienel, Angelika; Schlaefke, Sandra; Stange, Rainer

doi:10.1016/j.phymed.2012.02.020

Cited by 31 publications

(17 citation statements)

References 23 publications

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“…1D) at similar concentrations (3–30 mg/kg) in accordance with Linck et al [8]. As Silexan does not show sedation in humans, this finding rather suggests sleep promoting than sedative properties [9], [10], [23]–[26].…”

Section: Resultssupporting

confidence: 84%

Lavender Oil-Potent Anxiolytic Properties via Modulating Voltage Dependent Calcium Channels

et al. 2013

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Recent clinical data support the clinical use of oral lavender oil in patients suffering from subsyndromal anxiety. We identified the molecular mechanism of action that will alter the perception of lavender oil as a nonspecific ingredient of aromatherapy to a potent anxiolytic inhibiting voltage dependent calcium channels (VOCCs) as highly selective drug target. In contrast to previous publications where exorbitant high concentrations were used, the effects of lavender oil in behavioral, biochemical, and electrophysiological experiments were investigated in physiological concentrations in the nanomolar range, which correlate to a single dosage of 80 mg/d in humans that was used in clinical trials. We show for the first time that lavender oil bears some similarities with the established anxiolytic pregabalin. Lavender oil inhibits VOCCs in synaptosomes, primary hippocampal neurons and stably overexpressing cell lines in the same range such as pregabalin. Interestingly, Silexan does not primarily bind to P/Q type calcium channels such as pregabalin and does not interact with the binding site of pregabalin, the α2δ subunit of VOCCs. Lavender oil reduces non-selectively the calcium influx through several different types of VOCCs such as the N-type, P/Q-type and T-type VOCCs. In the hippocampus, one brain region important for anxiety disorders, we show that inhibition by lavender oil is mainly mediated via N-type and P/Q-type VOCCs. Taken together, we provide a pharmacological and molecular rationale for the clinical use of the oral application of lavender oil in patients suffering from anxiety.

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Section: Resultssupporting

confidence: 84%

Lavender Oil-Potent Anxiolytic Properties via Modulating Voltage Dependent Calcium Channels

et al. 2013

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“…The efficacy and safety of Silexan in anxiety disorders as well as in generalized anxiety disorder (GAD) have been demonstrated in several clinical randomized controlled trials and in an open pilot study . Therapeutic benefit appears also in patients who suffer from neurasthenia, post‐traumatic stress disorder or somatization disorder . Silexan (80 mg/day) has a comparable efficacy with lorazepam (0.5 mg/day) in adults with GAD .…”

Section: Biological Activitiesmentioning

confidence: 99%

Linalool: a review on a key odorant molecule with valuable biological properties

Aprotosoaie

Hăncianu

Costache

et al. 2014

Flavour & Fragrance J

261

178

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This paper reports on the occurrence, biosynthesis, metabolism, biological and toxicological profile, and assessment of the authenticity of linalool. The main biological properties of linalool – sedative, anxiolytic, analgesic, anticonvulsant, anti‐inflammatory, local anaesthetic – are discussed in terms of the molecule's chirality influence, the mechanisms of activity and type of study (in vitro, in vivo, clinical studies). Also, there is a discussion of the recent data on the skin sensitizing potential of linalool based on numerous scientific studies which have been performed in the last few years. Comments of the authenticity assessment of linalool are made considering the limitations imposed by the chemical structure, vegetal matrix or processing methods, but also from the perspective of the powerful and sophisticated analytical techniques available today (GC‐C‐IRMS, enantio‐MDGC coupled to GC‐C‐IRMS, SNIF‐NMR). Copyright © 2014 John Wiley & Sons, Ltd.

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“…By comparison, it has been reported lavender to impair arithmetic reasoning, but not memory, when compared to cloves, with no concomitant effect on mood for either odor [102]. Application of oral lavender (80 mg/day) for six weeks in fifty patients suffering from neurasthenia or post-traumatic stress disorder showed significant improvements of their general mental health status and quality of life [103]. …”

Section: Human Studiesmentioning

confidence: 99%

Lavender and the Nervous System

Koulivand

Ghadiri

Gorji³

2013

Evidence-Based Complementary and Alternative Medicine

238

122

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Lavender is traditionally alleged to have a variety of therapeutic and curative properties, ranging from inducing relaxation to treating parasitic infections, burns, insect bites, and spasm. There is growing evidence suggesting that lavender oil may be an effective medicament in treatment of several neurological disorders. Several animal and human investigations suggest anxiolytic, mood stabilizer, sedative, analgesic, and anticonvulsive and neuroprotective properties for lavender. These studies raised the possibility of revival of lavender therapeutic efficacy in neurological disorders. In this paper, a survey on current experimental and clinical state of knowledge about the effect of lavender on the nervous system is given.

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Phase II trial on the effects of Silexan in patients with neurasthenia, post-traumatic stress disorder or somatization disorder

Cited by 31 publications

References 23 publications

Lavender Oil-Potent Anxiolytic Properties via Modulating Voltage Dependent Calcium Channels

Lavender Oil-Potent Anxiolytic Properties via Modulating Voltage Dependent Calcium Channels

Linalool: a review on a key odorant molecule with valuable biological properties

Lavender and the Nervous System

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