Phase inversion in p-xylene/water emulsions with the non-ionic surfactant pair sorbitan monolaurate/polyoxyethylene sorbitan monolaurate (Span 20/Tween 20)

Sajjadi, Shahriar; Zerfa, M.; Brooks, Brian W.

doi:10.1016/s0927-7757(02)00596-4

Cited by 60 publications

(39 citation statements)

References 19 publications

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“…However, it has been used as a spreading, penetrating, and an auxiliary emulsifier in paints, human foodstuffs, cosmetic, and pharmaceutical preparations. It is used as a physical stabilizing agent in many topical pharmaceutical formulations such as formulation of various drugs with lipidic nanocarriers in drug delivery systems as well (Sajjadi et al, 2003;Zhang et al, 2013). It is also frequently added to washing buffers such as phosphate-buffered saline (PBS) and tris-buffered saline to prevent non-specific binding in radioimmuno assays and various techniques that employ the enzyme-linked immunosorbent assays (Hoffman and Jump, 1986;Zampieri et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Cyto/Genotoxicity Study of Polyoxyethylene (20) Sorbitan Monolaurate (Tween 20)

Eskandani

Hamishehkar

Dolatabadi

2013

DNA and Cell Biology

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Polyoxyethylene (20) sorbitan monolaurate (tween 20) is a non-ionic surfactant that is widely used as an emulsifier and stabilizer in pharmaceutical formulations, food and cosmetic industries. Although a number of studies have showed its non-toxic impacts on target cells, still, it is essential to investigate its effect on target cells. Therefore, in the present study, the anti-cell proliferation and cyto/genotoxicity effects of tween 20 are reported to address the possible mechanism for induction of apoptosis. At 40%-50% confluency, A549 cells and human umbilical vein endothelial cells were exposed to tween 20 at a recommended concentration for 24 h. After 24 h, to detect apoptosis and DNA damage, the treated cells were subjected to 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, fluorescein isothiocyanate (FITC)-labeled annexin V flow cytometry, DAPI staining, comet, and DNA ladder assays. Tween 20 decreased the growth of treated cells dose and time dependently, and single-strand DNA cleavage has been confirmed by comet assay. In addition, morphological alteration of DAPI-stained cells showed clear fragmentation in the chromatin and DNA rings within the nucleus of tween 20-treated cells. In addition, flow cytometry and DNA fragmentation assays confirmed DAPI staining assay results and indicated the occurrence of a programmed cell death (apoptosis) in the treated cells. These results demonstrate that, despite consideration of tween 20 as a safe non-ionic surfactant, it can induce apoptosis in target cells.

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Section: Introductionmentioning

confidence: 99%

Cyto/Genotoxicity Study of Polyoxyethylene (20) Sorbitan Monolaurate (Tween 20)

Eskandani

Hamishehkar

Dolatabadi

2013

DNA and Cell Biology

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“…As emulsões são compostas basicamente de três componentes: água, óleo e tensoativo, sendo que as propriedades físico-químicas destes influem enormemente no comportamento do sistema (SAJJADI, ZERFA, BROOKS, 2003).…”

Section: Emulsõesunclassified

Desenvolvimento e avaliação de nanoemulsões com óleos de Carapa guianensis e Copaifera sp. e estudo da ação repelente frente a Aedes aegypti.

Oliveira¹

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“…Hence, Span‐80 was used to stabilize the PEI solution‐in‐liquid paraffin emulsion for preparing the PA‐M microsphere . The selection of surfactant in the preparation of emulsions is often made based on a semi‐empirical scale, hydrophile‐lipophile balance (HLB) number . It is well known that a certain mixture of surfactants usually yield more stable emulsions than pure surfactants for a wider variety of application .…”

Section: Introductionmentioning

confidence: 99%

Stability of polyethylenimine solution‐in‐liquid paraffin emulsion for preparing polyamine microspheres with potential adsorption for ionic dyes

Huang

Wang

Zhu

et al. 2019

Asia-Pacific J Chem Eng

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A microsphere synthesized by emulsion crosslinking of polyethylenimine (PEI) was applied in the removal of ionic dyes from water. Firstly, the stability of the PEI solution-in-liquid paraffin emulsion was improved by using the mixture of Span-80/Tween-80 as the emulsifier. The optimization by 2 5-1 fractional factorial design demonstrated the most stable emulsion was prepared at 0.07 g/mL of the emulsifier dosage, 6:4 (v:v) of the oil/water ratio, 20 % (wt %) of the PEI concentration, 6:1 (w:w) of the Span-80/Tween-80 ratio with a homogenization speed of 6000 r/min for 3 min at 25 o C. Then, the polyamine microsphere (PA-M) was obtained by crosslinking the PEI emulsion with glutaraldehyde. The PA-M microsphere can adsorb xylenol orange (XO) from aqueous solution with a capacity of 1169.2±12.5 mg/g. The amount of XO adsorption remained constant in the pH range of 2.0-11.0. Adsorption kinetics analysis demonstrated that Pseudo first-order model fit the experimental data better, indicating the overall adsorption process was controlled by 'surface reaction'. The XO adsorption on the microsphere was due to an electrostatic interaction according to the results of ΔG evaluation. The value of separation factor suggested the XO adsorption was favorable. The used PA-M microsphere can be regenerated and reused in adsorption/desorption operation at least 20 times.

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Phase inversion in p-xylene/water emulsions with the non-ionic surfactant pair sorbitan monolaurate/polyoxyethylene sorbitan monolaurate (Span 20/Tween 20)

Cited by 60 publications

References 19 publications

Cyto/Genotoxicity Study of Polyoxyethylene (20) Sorbitan Monolaurate (Tween 20)

Cyto/Genotoxicity Study of Polyoxyethylene (20) Sorbitan Monolaurate (Tween 20)

Desenvolvimento e avaliação de nanoemulsões com óleos de Carapa guianensis e Copaifera sp. e estudo da ação repelente frente a Aedes aegypti.

Stability of polyethylenimine solution‐in‐liquid paraffin emulsion for preparing polyamine microspheres with potential adsorption for ionic dyes

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