Phase transitions in single phase Si–Ca–P-based ceramic under thermal treatment

Lugo, Gerardo J.; Mazón, Patricia; Aza, Piedad N. De

doi:10.1016/j.jeurceramsoc.2015.04.036

Cited by 19 publications

(22 citation statements)

References 32 publications

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“…The aims of the present work were to study a new porous Nurse's A ceramic (Si‐Ca‐P‐based material) bone substitute (Lugo et al. ,b) and examine its mechanical properties in vitro and their biocompatibility, osteoinductivity, and resorption process in vivo .…”

mentioning

confidence: 99%

Retracted: Bone neoformation of a novel porous resorbable Si‐Ca‐P‐based ceramic with osteoconductive properties: physical and mechanical characterization, histological and histomorphometric study

Aza

Val

Baudin

et al. 2016

Clinical Oral Implants Res

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confidence: 99%

Retracted: Bone neoformation of a novel porous resorbable Si‐Ca‐P‐based ceramic with osteoconductive properties: physical and mechanical characterization, histological and histomorphometric study

Aza

Val

Baudin

et al. 2016

Clinical Oral Implants Res

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“…The P–O stretching vibration (ν 3 ) of the PO 4 unit occurred within the 1030–1090 cm −1 range. As this is overlaid with the strong vibration of the Si–O bond (the ν 3 mode in the SiO 4 unit), it is difficult to distinguish the P–O vibration from the Si–O vibration [31,32]. …”

Section: Resultsmentioning

confidence: 99%

A New Biphasic Dicalcium Silicate Bone Cement Implant

Zuleta

Murciano

Gehrke³

et al. 2017

Materials

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This study aimed to investigate the processing parameters and biocompatibility of a novel biphasic dicalcium silicate (C2S) cement. Biphasic α´L + β-C2Sss was synthesized by solid-state processing, and was used as a raw material to prepare the cement. In vitro bioactivity and biocompatibility studies were assessed by soaking the cement samples in simulated body fluid (SBF) and human adipose stem cell cultures. Two critical-sized defects of 6 mm Ø were created in 15 NZ tibias. A porous cement made of the high temperature forms of C2S, with a low phosphorous substitution level, was produced. An apatite-like layer covered the cement’s surface after soaking in SBF. The cell attachment test showed that α´L + β-C2Sss supported cells sticking and spreading after 24 h of culture. The cement paste (55.86 ± 0.23) obtained higher bone-to-implant contact (BIC) percentage values (better quality, closer contact) in the histomorphometric analysis, and defect closure was significant compared to the control group (plastic). The residual material volume of the porous cement was 35.42 ± 2.08% of the initial value. The highest BIC and bone formation percentages were obtained on day 60. These results suggest that the cement paste is advantageous for initial bone regeneration.

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“…Details of the technique and characterisation of the starting materials can be found in previous publications [21,22,23,24]. …”

Section: Methodsmentioning

confidence: 99%

Assessment of Effects of Si-Ca-P Biphasic Ceramic on the Osteogenic Differentiation of a Population of Multipotent Adult Human Stem Cells

et al. 2016

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A new type of bioceramic with osteogenic properties, suitable for hard tissue regeneration, was synthesised. The ceramic was designed and obtained in the Nurse’s A-phase-silicocarnotite subsystem. The selected composition was that corresponding to the eutectoid 28.39 wt % Nurse’s A-phase-71.61 wt % silicocarnotite invariant point. We report the effect of Nurse’s A-phase-silicocarnotite ceramic on the capacity of multipotent adult human mesenchymal stem cells (ahMSCs) cultured under experimental conditions, known to adhere, proliferate and differentiate into osteoblast lineage cells. The results at long-term culture (28 days) on the material confirmed that the undifferentiated ahMSCs cultured and in contact with the material surface adhered, spread, proliferated, and produced a mineralised extracellular matrix on the studied ceramic, and finally acquired an osteoblastic phenotype. These findings indicate that it underwent an osteoblast differentiation process. All these findings were more significant than when cells were grown on plastic, in the presence and absence of this osteogenic supplement, and were more evident when this supplement was present in the growth medium (GM). The ceramic evaluated herein was bioactive, cytocompatible and capable of promoting the proliferation and differentiation of undifferentiated ahMSCs into osteoblasts, which may be important for bone integration into the clinical setting.

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Phase transitions in single phase Si–Ca–P-based ceramic under thermal treatment

Cited by 19 publications

References 32 publications

Retracted: Bone neoformation of a novel porous resorbable Si‐Ca‐P‐based ceramic with osteoconductive properties: physical and mechanical characterization, histological and histomorphometric study

Retracted: Bone neoformation of a novel porous resorbable Si‐Ca‐P‐based ceramic with osteoconductive properties: physical and mechanical characterization, histological and histomorphometric study

A New Biphasic Dicalcium Silicate Bone Cement Implant

Assessment of Effects of Si-Ca-P Biphasic Ceramic on the Osteogenic Differentiation of a Population of Multipotent Adult Human Stem Cells

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