2014
DOI: 10.3174/ajnr.a3969
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Phase White Matter Signal Abnormalities in Patients with Clinically Isolated Syndrome and Other Neurologic Disorders

Abstract: BACKGROUND AND PURPOSE:Identifying MRI biomarkers that can differentiate multiple sclerosis patients from other neurological disorders is a subject of intense research. Our aim was to investigate phase WM signal abnormalities for their presence, prevalence, location, and diagnostic value among patients with clinically isolated syndrome and other neurologic disorders and age-, sex-, and group-matched healthy controls.

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Cited by 12 publications
(10 citation statements)
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“…60 White matter signal abnormalities on SWI also tend to be more predictive of conversion to clinically definite MS than are T2 lesions, and venocentric and hypointense rim lesions are specific findings that are useful for differentiating patients with CIS or MS from those with other neurological disorders. 42,48,61 Future studies should investigate whether these findings further improve the specificity of MRI diagnosis of MS.…”
Section: Differential Diagnosis Via Detection Of Iron and Veinsmentioning
confidence: 99%
“…60 White matter signal abnormalities on SWI also tend to be more predictive of conversion to clinically definite MS than are T2 lesions, and venocentric and hypointense rim lesions are specific findings that are useful for differentiating patients with CIS or MS from those with other neurological disorders. 42,48,61 Future studies should investigate whether these findings further improve the specificity of MRI diagnosis of MS.…”
Section: Differential Diagnosis Via Detection Of Iron and Veinsmentioning
confidence: 99%
“…In a recent study in patients with clinically isolated syndrome who converted to clinically definite MS within a 3-year follow-up period versus those who did not, converters had significantly (p = 0.008) more phase lesions, but not T2WM or T1WM lesions; although the phase contrast could have been influenced by demyelination or other factors, the predictive value of phase lesions could imply a role in early disease pathology [Hagemeier et al 2014]. These findings are in line with observations that phase contrast observed in MS WM lesions is dynamic and may be visible at early disease onset [Yablonskiy et al 2012;Chen et al 2014].…”
Section: Discussionmentioning
confidence: 99%
“…An overview of the SWI processing, lesion analysis method, and reproducibility results used in the present study is discussed elsewhere [Hagemeier et al 2012b[Hagemeier et al , 2014. Each subject's images and WM lesion maps were coregistered with functional MRI of the brain's linear image registration tool (FLIRT) using 6 degrees of freedom (rigid body) [Jenkinson and Smith, 2011].…”
Section: Mri Assessmentsmentioning
confidence: 99%
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“…Phase white matter (WM) lesions were classified using a manual region-of-interest approach previously shown to be reproducible (Hagemeier et al, , 2014. Image analyses were carried out by a single operator who was blinded to clinical status.…”
Section: Data Collectionmentioning
confidence: 99%