Phellodendron and Citrusextracts benefit cardiovascular health in osteoarthritis patients: a double-blind, placebo-controlled pilot study

Oben, Julius Enyong; Enonchong, Ebangha; Kothari, Shil; Chambliss, Walter G.; Garrison, Robert D.; Dolnick, Deanne

doi:10.1186/1475-2891-7-16

Cited by 12 publications

(2 citation statements)

References 16 publications

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“…Citrus peels and/or extract have been reported to have various beneficial effects on humans, e.g., body weight control [ 171 ], promote cardiovascular health [ 172 ], improve hepatic steatosis [ 173 ] and cancer prevention [ 174 , 175 ]. Although consisting of only a few cases, one clinical study has demonstrated that PMF-rich citrus peel extract prevents the progression of cognitive dysfunction in AD patients on donepezil therapy [ 176 ].…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Citrus-Derived Polymethoxylated Flavones for Central Nervous System Disorders

Matsuzaki

Ohizumi

2021

Nutrients

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The number of patients with central nervous system disorders is increasing. Despite diligent laboratory and clinical research over the past 30 years, most pharmacologic options for the prevention and long-term treatment of central nervous system disorders and neurodegenerative disorders have been unsuccessful. Therefore, the development of drugs and/or functional foods to prevent the onset of neurodegenerative disorders is highly expected. Several reports have shown that polymethoxylated flavones (PMFs) derived from citrus fruit, such as nobiletin, tangeretin, and 3,3′,4′,5,6,7,8-heptamethoxyflavone, are promising molecules for the prevention of neurodegenerative and neurological disorders. In various animal models, PMFs have been shown to have a neuroprotective effect and improve cognitive dysfunction with regard to neurological disorders by exerting favorable effects against their pathological features, including oxidative stress, neuroinflammation, neurodegeneration, and synaptic dysfunction as well as its related mechanisms. In this review, we describe the profitable and ameliorating effects of citrus-derived PMFs on cognitive impairment and neural dysfunction in various rat and murine models or in several models of central nervous system disorders and identify their mechanisms of action.

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Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Citrus-Derived Polymethoxylated Flavones for Central Nervous System Disorders

Matsuzaki

Ohizumi

2021

Nutrients

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“…However, a study by Min et al [ 64 ] using the same product in a similarly designed randomized, placebo-controlled crossover study observed no effect on systolic or diastolic blood pressure or on the rate-corrected QT (QTc) interval. One eight-week placebo-controlled double-blind study has reported a small but significant decrease in systolic and diastolic blood pressures following ingestion of a product containing a Citrus peel extract [ 80 ]. A significant loss of weight as well as decreases in fasting glucose, triglycerides, and cholesterol were also observed.…”

Section: Observed Cardiovascular Effectsmentioning

confidence: 99%

A Review of the Receptor-Binding Properties ofp-Synephrine as Related to Its Pharmacological Effects

Stohs

Preuss

Shara

2011

Oxidative Medicine and Cellular Longevity

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Bitter orange (Citrus aurantium) extract and its primary protoalkaloid p-synephrine are used widely in weight loss/weight management and sports performance products. Because of structural similarities, the pharmacological effects of p-synephrine are widely assumed to be similar to those of ephedrine, m-synephrine (phenylephrine), and endogenous amine neurotransmitters as norepinephrine and epinephrine. However, small structural changes result in the receptor binding characteristics of these amines that are markedly different, providing a plausible explanation for the paucity of adverse effects associated with the wide-spread consumption of p-synephrine in the form of dietary supplements as well as in various Citrus foods and juices. This paper summarizes the adrenoreceptor binding characteristics of p-synephrine relative to m-synephrine, norepinephrine, and other amines as related to the observed pharmacological effects.

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Potential Value‐Added Co‐products from Citrus Fruit Processing

Manthey

Bergeron²,

Carrier

et al. 2012

Biorefinery Co‐Products

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Phellodendron and Citrusextracts benefit cardiovascular health in osteoarthritis patients: a double-blind, placebo-controlled pilot study

Abstract: Background: The objective of this clinical study was to assess the potential benefit of a dietary supplement, NP 06-1, on cardiovascular protective properties in overweight and normal weight adults diagnosed with osteoarthritis of the knee.

Cited by 12 publications

References 16 publications

Beneficial Effects of Citrus-Derived Polymethoxylated Flavones for Central Nervous System Disorders

Beneficial Effects of Citrus-Derived Polymethoxylated Flavones for Central Nervous System Disorders

A Review of the Receptor-Binding Properties ofp-Synephrine as Related to Its Pharmacological Effects

Potential Value‐Added Co‐products from Citrus Fruit Processing

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