Phenacetin nephropathy in a patient with an ileostomy

Dyer, N. H.; Lee, F. I.

doi:10.1136/pgmj.43.506.791

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1970

1978

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Cited by 4 publications

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“…One of these had a glueose-6-phosphate dehydrogenase deficieney with an associated methemoglobinemia. Dyer and Lee 24 reported "phenacetin nephropathy" in a patient with an ileostomy who had taken eompound eodeine tablets for their eonstipating effect. Kasanerr" followed up 152 patients who had "indulged in heavy use of mixed powders."…”

Section: Recent C1inical Papersmentioning

confidence: 98%

Analgesie nephropathy‐A review of the literature, 1967–1970

Abel¹

1971

Clin Pharma and Therapeutics

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Section: Recent C1inical Papersmentioning

confidence: 98%

Analgesie nephropathy‐A review of the literature, 1967–1970

Abel¹

1971

Clin Pharma and Therapeutics

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Nephropathie durch Analgetica

Gsell¹

1974

Ergebnisse Der Inneren Medizin Und Kinderheilkunde / Advances in Internal Medicine and Pediatrics

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Genesis of analgesic nephropathy in the United Kingdom

Murray

1978

Kidney International

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Analgesic nephropathy is more common in Western Scotland than elsewhere in the United Kingdom. This appears to be a consequence of the frequency with which local people take Askit, a preparation different from most other British analgesics in that they contain more caffeine and in their presentation as powders. Surveys of different populations in Glasgow suggest that while aspirin and paracetamol tend to be taken relatively infrequently and for appropriate reasons such as pain, Askit is more likely to be taken with excessive frequency for its supposed mood-altering properties. Working-class women with psychiatric problems are especially prone to daily self-medication. Study of individuals with analgesic nephropathy reveals that in Western Scotland, at least, the cause is dependence on analgesics. The characteristics of this include a need to continue taking and to slowly increase the dose of analgesics, partly owing to tolerance and partly to treat symptoms the analgesic ingestion has caused, as well as a psychic dependence resulting from appreciation of the psychotropic effects of the compound analgesics. When compared with matched controls, those who develop the "analgesic abuse syndrome" are more likely to have a family history of analgesic abuse, alcoholism, and psychiatric disorder. They tend to be introverted and neurotic, are prone to abuse other drugs and many have had previous psychiatric treatment.

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Phenacetin nephropathy in a patient with an ileostomy

Cited by 4 publications

References 11 publications

Analgesie nephropathy‐A review of the literature, 1967–1970

Analgesie nephropathy‐A review of the literature, 1967–1970

Nephropathie durch Analgetica

Genesis of analgesic nephropathy in the United Kingdom

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