Phenanthroline-modified DNA three-way junction structures stabilized by interstrand 3 : 1 metal complexation

Takezawa, Yusuke; Kanemaru, Daisuke; Kudo, Naofumi; Shionoya, Mitsuhiko

doi:10.1039/d3dt01508d

Cited by 5 publications

(1 citation statement)

References 66 publications

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“…The synthesis of different metal complexes with phenanthroline ligands and the study of their binding to the DNA molecule have been carried out [11][12][13][14][15][16][17]. Some metal ions play an essential role in different biochemical functions.…”

Section: Introductionmentioning

confidence: 99%

DNA Interaction with Coordination Compounds of Cd(II)containing 1,10-Phenanthroline

Kasyanenko,

Belyi,

Silanteva

et al. 2024

IJMS

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The experimental study of the DNA interaction with three cadmium coordination compounds [Cd(phen)3](CH3CO2)2, [Cd(phen)2(H2O)2](CH3CO2)2, and [Cd2(phen)4(H2O)2](CH3CO2)4 was carried out using spectrophotometry, viscosity, and dynamic light scattering methods. The role of the solution ionic strength (concentration of NaCl) was analyzed. All compounds can penetrate (fully or partly) to the major or minor DNA grooves. It was shown that, in addition to the important role of electrostatic interactions in the formation of the complex, intercalation of the 1,10-phenanthroline ligand occurs for compounds [Cd(phen)2(H2O)2](CH3CO2)2 and [Cd2(phen)4(H2O)2](CH3CO2)4. Compound [Cd(phen)3](CH3CO2)2 binds to DNA externally. The coordination bond between cadmium and DNA was formed in DNA complexes with [Cd2(phen)4(H2O)2](CH3CO2)4. Preliminary computer modeling of the DNA interaction with the compounds used was performed.

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Section: Introductionmentioning

confidence: 99%

DNA Interaction with Coordination Compounds of Cd(II)containing 1,10-Phenanthroline

Kasyanenko,

Belyi,

Silanteva

et al. 2024

IJMS

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General Introduction

Mori

2024

Springer Theses

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Rational design of metal-responsive functional DNA supramolecules

Takezawa

2024

J Incl Phenom Macrocycl Chem

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DNA molecules have excellent molecular recognition abilities through the complementary hydrogen-bonded base pairing. Since the hybridization of oligonucleotides can be programmed based on the sequences of the nucleobases, a great number of DNA supramolecular architectures have been constructed via self-assembly processes. The development of stimuli-responsive DNA supramolecules has attracted increasing interests because it will contribute to the construction of dynamic molecular systems such as molecular machines. Metal ions are considered as useful chemical stimuli, but the construction of metal-responsive DNA systems is still in the early stage. This review article describes current progress on the development of DNA supramolecules whose structure and function can be regulated in response to metal ions, with mainly focusing on our recent studies. The basic strategy is the introduction of unnatural metal ligands that form interstrand metal complexes in DNA structures. For example, artificial metal-mediated base pairs, formed through complexation between ligand-type nucleobase analogs and a bridging metal ion, were incorporated into known DNAzymes (catalytic DNA) to allosterically regulate their activity in a metal-responsive manner. Novel ligand-type nucleobases that form both metal-mediated and hydrogen-bonded base pairs have been recently devised as metal-responsive building blocks, and were used to construct a simple prototype of DNA molecular machines. Branched DNA structures bearing metal ligands at the junction core were also synthesized as novel structural motifs, with which metal-mediated structure transformation was demonstrated. These metal-responsive DNA supramolecules are expected to expand the toolbox of DNA-based supramolecular chemistry and nanotechnology.

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Phenanthroline-modified DNA three-way junction structures stabilized by interstrand 3 : 1 metal complexation

Abstract: Incorporation of interstrand metal complexes into DNA is a versatile strategy for metal-dependent stabilization and structural induction of DNA supramolecular structures. In this study, we have synthesized DNA three-way junction...

Cited by 5 publications

References 66 publications

DNA Interaction with Coordination Compounds of Cd(II)containing 1,10-Phenanthroline

DNA Interaction with Coordination Compounds of Cd(II)containing 1,10-Phenanthroline

General Introduction

Rational design of metal-responsive functional DNA supramolecules

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