Phencomycin, a New Antibiotic from a Streptomyces Species HIL Y-9031725.

Chatterjee, S. K.; Vijayakumar, E. K. S.; Franco, Christopher M. M.; Maurya, Raj Kumar; Blumbach, J.; Ganguli, B. N.

doi:10.7164/antibiotics.48.1353

Cited by 29 publications

(15 citation statements)

References 3 publications

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“…(Ge et al 2004) as well as marine Streptomycete (Pusecker et al 1997). Besides its antitumor activity, compound (1) possesses antimicrobial activities (Chatterjee et al 1995;Gebhardt et al 2002). According to our antimicrobial tests, we have observed that this compound presents antibacterial activities against Gram-positive and Gram-negative bacteria as well as antifungal activities (Table 4).…”

Section: Physiological Characteristicsmentioning

confidence: 95%

“…This active molecule has been already described from Streptomyces sp. (Chatterjee et al 1995;Gebhardt et al 2002) and terrestrial Pseudomonas sp. (Ge et al 2004) as well as marine Streptomycete (Pusecker et al 1997).…”

Section: Physiological Characteristicsmentioning

confidence: 99%

“…This latter way is the most useful and several classes of antibiotics can be distinguished, as: alkaloid derivatives which possess a diverse range of biological activities, e.g. anticancer and antimicrobial (Chatterjee et al 1995;Gebhardt et al 2002); phthalate derivatives which are biologically active compounds (Marchetti et al 2002); nonadecene compounds known for their antioxidant (Yassa et al 2009) and antifungal activities (El-Sakhawy et al 1998); diketopiperazine (DKP) derivatives having useful biological properties (Ben Ameur Mehdi et al 2004, etc. Despite the large number of species with validly published names, the genus Streptomyces as a whole is underspeciated (Kim and Goodfellow 2002).…”

Section: Introductionmentioning

confidence: 98%

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Taxonomy, purification and chemical characterization of four bioactive compounds from new Streptomyces sp. TN256 strain

Smaoui

Mathieu²,

Elleuch³

et al. 2011

World J Microbiol Biotechnol

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A new actinomycete strain designated TN256, producing antimicrobial activity against pathogenic bacteria and fungi, was isolated from a Tunisian Saharan soil. Morphological and chemical studies indicated that strain TN256 belonged to the genus Streptomyces. Analysis of the 16S rDNA sequence of strain TN256 showed a similarity level ranging between 99.79 and 97.8% within Streptomyces microflavus DSM 40331(T) and Streptomyces griseorubiginosus DSM 40469(T) respectively. The comparison of its physiological characteristics showed significant differences with the nearest species. Combined analysis of the 16 S rRNA gene sequences (FN687758), fatty acids profile, and results of physiological and biochemical tests indicated that there were genotypic and phenotypic differentiations of that isolate from other Streptomyces species neighbours. These date strongly suggest that strain TN256 represents a novel species with the type strain Streptomyces TN256 (=CTM50228(T)). Experimental validation by DNA-DNA hybridization would be required for conclusive confirmation. Four active products (1-4) were isolated from the culture broth of Streptomyces TN256 using various separation and purification steps and procedures. 1: N-[2-(1H-indol-3-yl)-2 oxo-ethyl] acetamide 'alkaloid' derivative; 2: di-(2-ethylhexyl) phthalate, a phthalate derivative; 3: 1-Nonadecene and 4: Cyclo (L: -Pro-L: -Tyr) a diketopiperazine 'DKP' derivative. The chemical structure of these four active compounds was established on the basis of spectroscopic studies NMR and by comparing with data from the literature. According to our biological studies, we showed in this work that the pure compounds (1-4) possess antibacterial and antifungal activities.

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Section: Physiological Characteristicsmentioning

confidence: 95%

Section: Physiological Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Taxonomy, purification and chemical characterization of four bioactive compounds from new Streptomyces sp. TN256 strain

Smaoui

Mathieu²,

Elleuch³

et al. 2011

World J Microbiol Biotechnol

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“…30) The known phenazine-1-carboxylic acid (22), 26) phencomycin (23), 31) and phenazine-1,6-dicarboxylic acid (24) 24) were also isolated (Fig. 5).…”

Section: Phenazine and Sulfonic Acid Derivativesmentioning

confidence: 99%

Bioactive Secondary Metabolites with Unique Aromatic and Heterocyclic Structures Obtained from Terrestrial Actinomycetes Species

2016

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Natural products from actinomycetes are important and valuable sources for drug discovery and the development of biological tools. The present review describes our recent study on the isolation of new natural products mainly possessing heterocyclic and aromatic ring structures with biological effects on cancerrelated cellular pathways such as tumor necrosis factor-α-related apoptosis-inducing ligand (TRAIL) and Wnt signaling.

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“…The carbon resonances of C-4a, C-5a, C-9a, and C-10a indicated a phenazine based structure. An exact mass search in the Database of Natural Products and comparison of the spectral data with literature [21] determined compound 2 as a known phenazine compound phencomycin which was previously isolated from Streptomyces sp. derived from terrestrial [21,22] and marine sources [23].…”

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confidence: 99%

Strepoxazine A, a new cytotoxic phenoxazin from the marine sponge-derived bacterium Streptomyces sp. SBT345

Cheng

Othman

Fekete

et al. 2016

Tetrahedron Letters

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One new phenoxazin analogue, strepoxazine A (1), along with two known antibiotic phenazines phencomycin (2) and tubermycin B (3) were isolated from the solid culture of Streptomyces sp. SBT345 which had previously been recovered from the Mediterranean sponge Agelas oroides. The structures of compounds 1, 2 and 3 were determined by spectroscopic analyses including 1D and 2D NMR, and HR-ESI-MS experiments as well as comparison to the literature. We further investigated the apoptotic effect of the three compounds on the human promyelocytic leukaemia cells HL-60 and human breast adenocarcinoma cells MCF-7. Only strepoxazine A (1) showed cytotoxicity against leukaemia cells HL-60 cells. These results demonstrate that sponge-associated actinomycetes are rich sources for natural products with new pharmacological activities and relevance to drug discovery

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Phencomycin, a New Antibiotic from a Streptomyces Species HIL Y-9031725.

Cited by 29 publications

References 3 publications

Taxonomy, purification and chemical characterization of four bioactive compounds from new Streptomyces sp. TN256 strain

Taxonomy, purification and chemical characterization of four bioactive compounds from new Streptomyces sp. TN256 strain

Bioactive Secondary Metabolites with Unique Aromatic and Heterocyclic Structures Obtained from Terrestrial Actinomycetes Species

Strepoxazine A, a new cytotoxic phenoxazin from the marine sponge-derived bacterium Streptomyces sp. SBT345

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