Phenolate-bridged zinc(II) complexes relevant to biological phosphoester cleavage

Grünwald, Katrin R.; Volpe, Manuel; Mösch‐Zanetti, Nadia C.

doi:10.1080/00958972.2012.688117

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…This kind of metal bridging ability of the phenolate ligand is very common. 25,[34][35][36][37] 4 is a neutral complex and contains an inversion center which allows transformation of equivalent atoms via −x + 1, −y + 1, −z + 1. Although it is common for phenolate to act as a bridging moiety between two metal centers, to the best of our knowledge, diferrous bis(μ-phenoxy) complexes with an additional N3 donor around each iron center have not been reported thus far.…”

Section: X-ray Structuresmentioning

confidence: 99%

Redox and acid–base properties of asymmetric non-heme (hydr)oxo-bridged diiron complexes

et al. 2014

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The diiron unit is commonly found as the active site in enzymes that catalyze important biological transformations. Two μ-(hydr)oxo-diiron(iii) complexes with the ligands 2,2'-(2-methyl-2-(pyridine-2-yl)propane-1,3-diyl)bis(azanediyl)bis(methylene)diphenol (H2L) and 2,2'-(2-methyl-2(pyridine-2-yl)propane-1,3-diyl)bis(azanediyl)bis(methylene)bis(4-nitrophenol) (H2L(NO2)), namely [(FeL)2(μ-O)] () and [(FeL(NO2))2(μ-OH)]ClO4 () were synthesized and characterized. In the solid state, both structures are asymmetric, with unsupported (hydr)oxo bridges. Intramolecular hydrogen bonding of the ligand NH groups to the phenolate O atoms hold the diiron cores in a bent configuration (Fe-O-Fe angle of 143.7° for and 140.1° for ). A new phenolate bridged diferrous complex, [(FeL)2] (), was synthesized and characterized. Upon exposure to air the diferrous complex is oxidized to the diferric . Cyclic voltammetry at different scan rates and chemical reduction of [(FeL)2(μ-OH)]BPh4 () with cobaltocene revealed disproportionation followed by proton transfer, and a mixed-valence species could not be trapped. Subsequent exposure to molecular oxygen results in the formation of . Electrochemical studies of indicate easier reduction of the diiron(iii/iii) to the mixed-valence state than for . The protonation of by benzoic acid to form [(FeL)2(μ-OH)](+) only changes the Fe-O-Fe angle by 5° (from 143.7° to 138.6°), and the pKa of the hydroxo bridge is estimated to be about 20.4. We attribute this high pKa partly to stabilization of the benzoate by hydrogen bonding to the ligand's amine proton. Magnetic susceptibility studies on solid samples of and yielded values of the antiferromagnetic exchange coupling constants, J, for these S = 5/2 dimers of -13.1 cm(-1) and -87.5 cm(-1), respectively, typical of such unsupported hydroxo- and oxo-bridges.

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Section: X-ray Structuresmentioning

confidence: 99%

Redox and acid–base properties of asymmetric non-heme (hydr)oxo-bridged diiron complexes

et al. 2014

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“…In addition, zinc can improve the immune defense due to its catalytic and regulatory functions, thus, enhancing resistance to infections. [22][23][24][25]…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative activity and conversion of tachyzoite to bradyzoite of Toxoplasma gondii promoted by new zinc complexes containing sulfadiazine

et al. 2015

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“…[1][2][3][4] But the severe toxic side effects of cis-dichlorodiamineplatinum(II) and its derivatives limit the dose that can be given to patients. Zinc is one of the most important metals in biological systems, [5][6][7][8] and a number of zinc complexes have been proved to possess antitumor activities. [9][10][11][12] Azide anion is a pseudohalide group, which also coordinates to the Zn atoms.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Crystal Structure, and Cytotoxiciy In Vitro of a Zinc(II) Complex

Miao

2015

Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-

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A mononuclear zinc(II) complex, [ZnClL(N 3 )], where L is 1,2-diaminocyclohexane, was synthesized and characterized by elemental analysis, IR spectrum, and single-crystal X-ray diffraction. The crystal of the complex crystallizes in the monoclinic space group P2 1 /m, with unit cell dimensions a D 6.146 (2) A , b D 7.042(2) A , c D 12.498(3) A , b D 99.782(3) , V D 533.1(2) A 3 , Z D 2, R 1 D 0.0517, wR 2 D 0.1470. The Zn atom of the complex is in a tetrahedral coordination, with two N atoms of the ligand L, one azide N atom, and one Cl atom. The complex has moderate level of resistance against cell lines HeLa, Hep-G2, KB, and AGZY-83a.

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Phenolate-bridged zinc(II) complexes relevant to biological phosphoester cleavage

Cited by 5 publications

References 33 publications

Redox and acid–base properties of asymmetric non-heme (hydr)oxo-bridged diiron complexes

Redox and acid–base properties of asymmetric non-heme (hydr)oxo-bridged diiron complexes

Antiproliferative activity and conversion of tachyzoite to bradyzoite of Toxoplasma gondii promoted by new zinc complexes containing sulfadiazine

Synthesis, Crystal Structure, and Cytotoxiciy In Vitro of a Zinc(II) Complex

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