Phenolic acids, cinnamic acid, and ergosterol as cosmeceutical ingredients: Stabilization by microencapsulation to ensure sustained bioactivity

Taofiq, Oludemi; Heleno, Sandrina A.; Calhelha, Ricardo C.; Fernandes, Isabel P.; Alves, Maria José; Barros, Lillian; González-Paramás, Ana M.; Ferreira, Isabel C.F.R.; Barreiro, María Filomena

doi:10.1016/j.microc.2019.03.059

Cited by 44 publications

(29 citation statements)

References 36 publications

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“…These phenolic acids are used as precursors in the synthesis of lignins and other phenolics [136]. Taofiq et al [156] conducted a study on individual compounds as possible ingredients in cosmeceutical formulations. The authors concluded that p-coumaric, protocatechuic, and cinnamic acids displayed anti-tyrosinase, antimicrobial, and anti-inflammatory activities, showing their potential for the cosmeceutical industry.…”

Section: Polyphenols As Extracted Biocompoundsmentioning

confidence: 99%

Green and Sustainable Valorization of Bioactive Phenolic Compounds from Pinus By-Products

et al. 2020

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In Europe, pine forests are one of the most extended forests formations, making pine residues and by-products an important source of compounds with high industrial interest as well as for bioenergy production. Moreover, the valorization of lumber industry residues is desirable from a circular economy perspective. Different extraction methods and solvents have been used, resulting in extracts with different constituents and consequently with different bioactivities. Recently, emerging and green technologies as ultrasounds, microwaves, supercritical fluids, pressurized liquids, and electric fields have appeared as promising tools for bioactive compounds extraction in alignment with the Green Chemistry principles. Pine extracts have attracted the researchers’ attention because of the positive bioproperties, such as anti-inflammatory, antimicrobial, anti-neurodegenerative, antitumoral, cardioprotective, etc., and potential industrial applications as functional foods, food additives as preservatives, nutraceuticals, pharmaceuticals, and cosmetics. Phenolic compounds are responsible for many of these bioactivities. However, there is not much information in the literature about the individual phenolic compounds of extracts from the pine species. The present review is about the reutilization of residues and by-products from the pine species, using ecofriendly technologies to obtain added-value bioactive compounds for industrial applications.

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Section: Polyphenols As Extracted Biocompoundsmentioning

confidence: 99%

Green and Sustainable Valorization of Bioactive Phenolic Compounds from Pinus By-Products

et al. 2020

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“…The ability of compound 46 to inhibit tyrosinase was credited to its ability to reduce microphthalmia-associated transcription factor (MITF) [77] and tyrosinase mRNA expression as high as 73% and 82%, respectively. The results showed that compound 46 has the potential to be used together with other bioactive ingredients for protection against hyperpigmentation [76]. Gunia-Krzyzak et al reported compound 46-containing cream that decreased erythema and pigmentation when applied daily on the foreskin arm [78].…”

Section: Cinnamic Acid Derivatives With Antioxidant and Anti-inflammamentioning

confidence: 99%

“…Its anti-inflammatory activity was measured to be EC 50 of 152 µg/mL and anti-tyrosinase activity of EC 50 ˃ 2.0 mg/mL. [ 76 ]. The ability of compound 46 to inhibit tyrosinase was credited to its ability to reduce microphthalmia-associated transcription factor (MITF) [ 77 ] and tyrosinase mRNA expression as high as 73% and 82%, respectively.…”

Section: Cinnamic Acid Derivatives With Antioxidant and Anti-inflamentioning

confidence: 99%

Cinnamic Acid Derivatives and Their Biological Efficacy

Ruwizhi

Aderibigbe

2020

IJMS

280

134

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The role played by cinnamic acid derivatives in treating cancer, bacterial infections, diabetes and neurological disorders, among many, has been reported. Cinnamic acid is obtained from cinnamon bark. Its structure is composed of a benzene ring, an alkene double bond and an acrylic acid functional group making it possible to modify the aforementioned functionalities with a variety of compounds resulting in bioactive agents with enhanced efficacy. The nature of the substituents incorporated into cinnamic acid has been found to play a huge role in either enhancing or decreasing the biological efficacy of the synthesized cinnamic acid derivatives. Some of the derivatives have been reported to be more effective when compared to the standard drugs used to treat chronic or infectious diseases in vitro, thus making them very promising therapeutic agents. Compound 20 displayed potent anti-TB activity, compound 27 exhibited significant antibacterial activity on S. aureus strain of bacteria and compounds with potent antimalarial activity are 35a, 35g, 35i, 36i, and 36b. Furthermore, compounds 43d, 44o, 55g–55p, 59e, 59g displayed potent anticancer activity and compounds 86f–h were active against both hAChE and hBuChE. This review will expound on the recent advances on cinnamic acid derivatives and their biological efficacy.

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“…Such positive effects were correlated with antioxidant and anti-tyrosine activities [ 119 ]. Phenolic acids, namely p -hydroxybenzoic, p -coumaric, and protocatechuic acids, showed stable bioactivities, e.g., antioxidant, anti-tyrosinase, and anti-inflammatory effects, when added in a cosmetic cream base [ 120 ].…”

Section: Potential Applications—food and Cosmetic Industries And Ementioning

confidence: 99%

Food Bioactive Compounds and Emerging Techniques for Their Extraction: Polyphenols as a Case Study

Câmara

Albuquerque

Aguiar

et al. 2020

Foods

Self Cite

131

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Experimental studies have provided convincing evidence that food bioactive compounds (FBCs) have a positive biological impact on human health, exerting protective effects against non-communicable diseases (NCD) including cancer and cardiovascular (CVDs), metabolic, and neurodegenerative disorders (NDDs). These benefits have been associated with the presence of secondary metabolites, namely polyphenols, glucosinolates, carotenoids, terpenoids, alkaloids, saponins, vitamins, and fibres, among others, derived from their antioxidant, antiatherogenic, anti-inflammatory, antimicrobial, antithrombotic, cardioprotective, and vasodilator properties. Polyphenols as one of the most abundant classes of bioactive compounds present in plant-based foods emerge as a promising approach for the development of efficacious preventive agents against NCDs with reduced side effects. The aim of this review is to present comprehensive and deep insights into the potential of polyphenols, from their chemical structure classification and biosynthesis to preventive effects on NCDs, namely cancer, CVDs, and NDDS. The challenge of polyphenols bioavailability and bioaccessibility will be explored in addition to useful industrial and environmental applications. Advanced and emerging extraction techniques will be highlighted and the high-resolution analytical techniques used for FBCs characterization, identification, and quantification will be considered.

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Phenolic acids, cinnamic acid, and ergosterol as cosmeceutical ingredients: Stabilization by microencapsulation to ensure sustained bioactivity

Cited by 44 publications

References 36 publications

Green and Sustainable Valorization of Bioactive Phenolic Compounds from Pinus By-Products

Green and Sustainable Valorization of Bioactive Phenolic Compounds from Pinus By-Products

Cinnamic Acid Derivatives and Their Biological Efficacy

Food Bioactive Compounds and Emerging Techniques for Their Extraction: Polyphenols as a Case Study

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