Phenolic Composition, Antioxidant and Anticancer Potentials of Extracts from Rosa banksiae Ait. Flowers

Zeng, Chen; Luo, Siyuan; Feng, Shiling; Chen, Tao; Zhou, Lijun; Yuan, Ming; Huang, Yan; Liao, Jinqiu; Ding, Chunbang

doi:10.3390/molecules25133068

Cited by 17 publications

(10 citation statements)

References 20 publications

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“…In vitro and in vivo investigations have shown few ethnopharmaceutical activities, including antioxidative, anti-inflammatory, and anti-neoplastic effects. 23,25,[51][52][53] Therefore, the present study revealed, for the first time, the beneficial health effects of LUT against DOX-induced oxido-inflammatory responses in the reproductive organs of male Wistar albino rats. Rats exposed to DOX exhibited marked (p < 0.05) diminutions in the mean body weight, thus indicating general toxicity and alterations of metabolic functions.…”

Section: Discussionmentioning

confidence: 85%

Luteolin abates reproductive toxicity mediated by the oxido-inflammatory response in Doxorubicin-treated rats

Owumi

Ijadele

Arunsi

et al. 2020

Toxicology Research and Application

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The anti-neoplastic use of Doxorubicin (DOX) is hampered by several limitations, including reproductive toxicity. Luteolin (LUT)–a phytochemical-biological benefits include antioxidative and anti-inflammatory actions. Here we examined the protective effect of LUT against DOX-induced reproductive toxicity in an in vivo model—male albino Wistar rats—randomly assigned to five groups and treated as follows: Control (corn oil 2 mL/kg; per os), LUT (100 mg/kg; per os), DOX (2 mg/kg) by intraperitoneal injections, co-treated groups received LUT (50 and 100 mg/kg) with DOX. Treatment with DOX alone, significantly (p > 0.05), reduced biomarkers of testicular function, reproductive hormone levels, testicular and epididymal antioxidant, and anti-inflammatory cytokine. DOX increased (p > 0.05) sperm morphological abnormalities, as well as reactive oxygen and nitrogen species, lipid peroxidation, xanthine oxidase, a pro-inflammatory cytokine, and apoptotic biomarkers. Furthermore, testicular and epididymal histological lesion complemented the observed biochemical changes in treated rats. LUT co-treatment resulted in a dosage-dependent improvement in rats’ survivability, antioxidants capacity, reduction in biomarkers of oxidative stress, pro-inflammatory cytokines, and apoptosis in rat’s testis and epididymis. Also, LUT treatment resulted in improved histological features in the testis and epididymis, relative to DOX alone treated rats. LUT co-treatment abated DOX-mediated reproductive organ injuries associated with pro-oxidative, inflammatory, and apoptotic mechanisms. LUT supplementation may serve as a phyto-protective agent in alleviating male reproductive organ toxic injuries associated with Doxorubicin therapy.

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Section: Discussionmentioning

confidence: 85%

Luteolin abates reproductive toxicity mediated by the oxido-inflammatory response in Doxorubicin-treated rats

Owumi

Ijadele

Arunsi

et al. 2020

Toxicology Research and Application

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“…Peroxidation of proteins, lipids, RNA, and DNA affects cellular function, thereby increasing the risk of cardiovascular disease and cancer, and accelerating the process of aging [ 48 ]. Gallic acid is a representative polyphenol that is reported to have alleviating effects on cellular DNA injury resulting from oxidative stress and is known to have many physiological uses owing to its antioxidant, antibacterial, anticancer, and anti-hypertension properties [ 49 ].…”

Section: Resultsmentioning

confidence: 99%

Effects of Allium sativum Stem Extract on Growth and Migration in Melanoma Cells through Inhibition of VEGF, MMP-2, and MMP-9 Genes Expression

et al. 2021

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The present study investigated the effects of Allium sativum stem extract (ASE) on B16-F0 cell growth and metastasis. Evaluation of the effects of ASE on B16-F0 cells’ viability and migration showed that 0.5 mg/mL ASE inhibited B16-F0 cells’ growth by 30.2% and migration by 38.5%, which indicates that the ASE has anticancer and antimetastatic effects on B16-F0 cells. To study the anticancer and antimetastatic mechanism, mRNA levels of vascular endothelial growth factor (VEGF), matrix metalloproteinases-2 (MMP-2), and matrix metalloproteinases-9 (MMP-9) expressions were evaluated with reverse transcription polymerase chain reaction, and 0.25 and 0.5 mg/mL ASE was found to exert significant inhibition on mRNA expressions of VEGF, MMP-2, and MMP-9 in B16-F0 cells. Thus, ASE reduce extracellular matrix degradation through inhibitions of expression of MMP-2 and MMP-9, and also showed an angiogenesis inhibitory effect through reduction of VEGF expression. High-performance liquid chromatography analysis showed that among various polyphenols, gallic acid (2.1 mg/g) was a major compound of ASE. Overall, our results demonstrated that ASE inhibited the growth and migration of B16-F0 cells through downregulation of the VEGF, MMP-2, and MMP-9 genes expression, which indicates ASE could be applied for the prevention and treatment of melanoma.

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“…banksiae Ait. (RBW) known as Banksian rose [4] were collected from Merry land Botanical Garden, Cairo, Egypt (30⁰05'37" N31⁰18'51"E), while Rosa polyantha Thunb. ‗Orange fairy' (RPO) and Rosa polyantha Thunb.…”

Section: Plant Materialsmentioning

confidence: 99%

“…The rose is named for Lady Banks, the wife of the botanist Sir Joseph Banks. It is largely cultivated in China especially in Southwest areas [4]. Rosa polyantha Thunb.…”

Section: Introductionmentioning

confidence: 99%

Botanical and Genetic Profiling of Three Rosa Varieties Cultivated in Egypt

Elhawary

Mostafa

Milad

et al. 2021

Archives of Pharmaceutical Sciences Ain Shams University

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Genus Rosa belongs to the family Rosaceae and comprises 100 species with a lot of popular ornamental and medicinal plants. Roses are usually utilized as an antioxidant, anti-inflammatory, antimicrobial, sleep aid, and in skin diseases. This study aimed to explore the macro-and micromorphological botanical features of the stems and leaves of three Rosa varieties; Rosa banksiae var. banksaie Ait. (Bankasian Rose) (RBW); R. polyantha Thunb. ‗orange fairy' (RPO) and R. polyantha Thunb. ‗white fairy' (RPW) together with DNA fingerprinting utilizing RAPD-PCR assay and Hierarchal Clustering Analysis (HCA) for the DNA results. The three varieties share the common characters of family Rosaceae viz. compound leaves, colored flowers, and anomocytic stomata while they differ in the color of their flowers, leaflets size, the number of leaflets, and their shapes and types of calcium oxalate. RAPD assay was utilized to differentiate the three varieties genetically where primers OP-P-8, OP-P-10, OP-P-11, OP-P-12, and OP-P-14 showed the highest degree of similarity between RPO and RPW. HCA revealed the closeness of the two polyantha roses forming one cluster in the resulting dendrogram which differentiated them from the Bankasian rose. DNA assay and chemometric analysis were following the botanical profiling.

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Phenolic Composition, Antioxidant and Anticancer Potentials of Extracts from Rosa banksiae Ait. Flowers

Cited by 17 publications

References 20 publications

Luteolin abates reproductive toxicity mediated by the oxido-inflammatory response in Doxorubicin-treated rats

Luteolin abates reproductive toxicity mediated by the oxido-inflammatory response in Doxorubicin-treated rats

Effects of Allium sativum Stem Extract on Growth and Migration in Melanoma Cells through Inhibition of VEGF, MMP-2, and MMP-9 Genes Expression

Botanical and Genetic Profiling of Three Rosa Varieties Cultivated in Egypt

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