Phenolic Compounds and Antioxidant Activity of &lt;i&gt;Nepeta nuda &lt;/i&gt;subsp.&lt;i&gt; Albiflora&lt;/i&gt;

Teber, İbrahim; Bursal, Ercan

doi:10.18052/www.scipress.com/ilns.79.1

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…In addition, the concentration of the different components in the methanol and water extracts might be different, and this was not specified in our data. In accordance with our results, the presence of flavones and hydroxycinnamic acid in the members of the Nepeta genus was reported in earlier studies [23][24][25][26][27].…”

Section: Resultssupporting

confidence: 94%

Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey

Zengin

Mahomoodally

Jekő

et al. 2021

Plants

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Nepeta baytopii is a poorly studied, endemic Nepeta species (Lamiaceae) of Turkey. For the first time, the biological activities (antioxidant, enzyme inhibition, and cytotoxicity properties) of the hexane, ethyl acetate, methanol, water/methanol, and water extracts and essential oil prepared from N. baytopii aerial parts were assessed. Hydro-methanol (41.25 mg gallic acid equivalent (GAE)/g) and water extracts (50.30 mg GAE/g), respectively showed the highest radical scavenging (94.40 and 129.22 mg Trolox equivalent (TE)/g, for 2,2-diphenyl-1-picrylhydrazyl radical and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid radical scavenging assays) and reducing (229.37 and 129.55 mg TE/g, for ferric-reducing antioxidant power and cupric-reducing antioxidant capacity assays) capacities in vitro. An interestingly high inhibition was observed for ethyl acetate extract against butyrylcholinesterase (10.85 mg galantamine equivalent/g). The methanol extract showed high cytotoxicity (31.7%) against HepG2 cells. Caryophyllene oxide was identified in high concentrations in the essential oil (39.3%). Luteolin and apigenin and their derivatives were identified from the methanol and water extracts. The results obtained from this study highlighted that the abundance of highly bioactive compounds from Nepeta baytopii ensures the multiple biological activities of the tested extracts, and this suggests a potential use in the pharmaceutical and nutraceutical fields, and therefore should be investigated further.

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Section: Resultssupporting

confidence: 94%

Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey

Zengin

Mahomoodally

Jekő

et al. 2021

Plants

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“…Among the targeted phenolic compounds, rosmarinic acid was the most abundant in all analyzed populations (Figure 4A). This was in accordance with previous studies, which highlighted rosmarinic acid as the major phenolic compound in N. nuda [10,14,15,20,63] and other Nepeta species [19,20,64,65]. Samples from Janjska reka displayed the highest amounts of this phenolic acid (6698 µg 100 mg −1 DW) followed by samples from Gornje Selo, Židilje, and Straža (Figure 4A).…”

Section: Targeted Qqqms Profiling Of Major Iridoids and Phenolics In ...supporting

confidence: 92%

Patterns of Genetic Variation of Nepeta nuda L. from the Central Balkans: Understanding Drivers of Chemical Diversity

Petrović,

Skorić,

Šiler

et al. 2024

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Nepeta nuda L., a notable medicinal species in the tradition of the Balkan region, is a rich source of bioactive iridoids and phenolics previously described as high-resolution taxonomical classifiers for the genus Nepeta. However, their potential in investigating intra-species differentiation is here described for the first time. The aim was to recognize the sources of natural chemical diversity and their association with the genetic variability both within and among N. nuda populations in the Central Balkans. Chemical diversity was assessed from methanol extracts and essential oils through untargeted and targeted metabolomics using state-of-the-art analytical tools, covering a broad spectrum of compounds that represent the N. nuda metabolome. We found that chemodiversity primarily resides within populations of N. nuda, and similar results were obtained at the DNA level using microsatellite markers. The low genetic and chemical differentiation of the studied N. nuda populations implies that their metabolomic profiles may be less influenced by geographic distance and variable environmental conditions within the Central Balkans, as they are under the pivotal control of their genetic backgrounds. Screening the distribution of the major bioactive compounds belonging to phenolics (phenolic acids and flavonoids) and iridoids (both aglycones and glycosylated forms), within and among N. nuda populations, is able to guarantee mass spectrometry-based tools for the selection of elite representative genotypes with practical importance. The knowledge acquired will allow us to delve deeper into the molecular background of N. nuda chemical diversity, which is the course of our further work.

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Phenolic Compounds and Antioxidant Activity of <i>Nepeta nuda </i>subsp.<i> Albiflora</i>

Cited by 2 publications

References 20 publications

Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey

Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey

Patterns of Genetic Variation of Nepeta nuda L. from the Central Balkans: Understanding Drivers of Chemical Diversity

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