Phenolic Compounds from Clinopodium urticifolium and Their Antivirus Activities

Abstract

A new phenolic compound, clinopodphenol B (1), together with six known phenols, were isolated from the whole plant of Clinopodium urticifolium. The structure of 1 was elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compound 1 was also tested for their anti HIV-1 activity and antitobacco mosaic virus activity. The results showed that compound 1 have modest anti HIV-1 activity and anti-tobacco mosaic virus activity, respectively.

Synthesis and Structure–Activity Relationship Studies of Nicot­lactone Analogues as Anti-TMV Agents

“…Structurally, these lignans isolated from N. tabacum possess an aryl ring attached with a -lactone or tetrahydrofuran motif, which has also been found in other secondary metabolites, including nicotlactone B (4), 11 clinopodphenol B (5), 12 6, 13 and tetrahydrofuranoid lignans [e.g., austrobailignan 7 (7) 11 ] (Figure 1). Typically, nicotlactone A (1) have three continuous stereocenters, one of which contains a hydroxy group next to the lactone ketone.…”

“…Structurally, these lignans isolated from N. tabacum possess an aryl ring attached with a γ-lactone or tetrahydrofuran motif, which has also been found in other secondary metabolites, including nicotlactone B (4), 11 clinopodphenol B (5), 12 6, 13 and tetrahydrofuranoid lignans [e.g. austrobailignan 7 (7) 11 ].…”

“…(12), 7.5068(13),13.858 (2) a, b, g (°)101.091 (5), 93.668 (5), 115.883 (4) article is protected by copyright. All rights reserved.…”