Phenolic compounds from the leaves and stem bark of Pseudospondias microcarpa (A. Rich.) Engl. (Anacardiaceae)

Guetchueng, Stéphanie Tamdem; Nahar, Lutfun; Ritchie, Kenneth J.; Ismail, Fyaz M.D.; Dempster, Nicola M.; Nnanga, Emmanuel; Sarker, Satyajit D.

doi:10.1016/j.bse.2020.104078

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…The 13 C NMR spectrum of 1 (Table 1 ) showed characteristic signals for the flavonoid skeleton at δ C 182.5 (C-4), 164.2 (C-2), 99.8 (C-6), and 95.0 (C-8). The pyranose from of the sugars was also revealed from the 13 C-NMR chemical shift values (Table 1 ) [ 37 – 39 ]. Based on 1 H, 13 C NMR and HSQC data, the signals at δ C 163.2 (C-4ʹ), 162.9 (C-7), 161.3 (C-5), δ H 6.83 (1H, s, H-8), and 6.41 (1H, s, H-6) shows that 1 is an 5,7,4ʹ-trisubstituted flavonoid.…”

Section: Resultsmentioning

confidence: 99%

Antiviral and anti-inflammatory activities of chemical constituents from twigs of Mosla chinensis Maxim

Feng,

Jiang,

Yang

et al. 2024

Nat. Prod. Bioprospect.

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Seven undescribed compounds, including three flavones (1–3), one phenylpropanoid (19), three monoaromatic hydrocarbons (27–29), were isolated from the twigs of Mosla chinensis Maxim together with twenty-eight known compounds. The structures were characterized by HRESIMS, 1D and 2D NMR, and ECD spectroscopic techniques. Compound 20 displayed the most significant activity against A/WSN/33/2009 (H1N1) virus (IC50 = 20.47 μM) compared to the positive control oseltamivir (IC50 = 6.85 µM). Further research on the anti-influenza mechanism showed that compound 20 could bind to H1N1 virus surface antigen HA1 and inhibit the early attachment stage of the virus. Furthermore, compounds 9, 22, 23, and 25 displayed moderate inhibitory effects on the NO expression in LPS inducing Raw 264.7 cells with IC50 values of 22.78, 20.47, 27.66, and 30.14 µM, respectively. Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

Antiviral and anti-inflammatory activities of chemical constituents from twigs of Mosla chinensis Maxim

Feng,

Jiang,

Yang

et al. 2024

Nat. Prod. Bioprospect.

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“…Few studies report the phytochemical analysis of this plant species. However, plants belonging to the Anacardiaceae family were previously reported to contain phytosterols such as β -sitosterol, stigmasterol, and phenolic compounds like scopoletin ( Pseudospondias macrocarpa ) [ 32 ]. Regarding their activity, the new antroklaicerebroside ( 1 ) exhibited a moderate and selective antiplasmodial activity against Pf 3D7 with an IC 50 value of 42.04 ± 0.08 µg/mL and a selectivity index greater than 11.…”

Section: Resultsmentioning

confidence: 99%

Antileishmanial and Antiplasmodial Activities of Secondary Metabolites from the Root of Antrocaryon klaineanum Pierre (Anacardiaceae)

et al. 2023

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Antrocaryon klaineanum is traditionally used for the treatment of back pain, malaria, female sterility, chlamydiae infections, liver diseases, wounds, and hemorrhoid. This work aimed at investigating the bioactive compounds with antileishmanial and antiplasmodial activities from A. klaineanum. An unreported glucocerebroside antroklaicerebroside (1) together with five known compounds (2–6) were isolated from the root barks of Antrocaryon klaineanum using chromatographic techniques. The NMR, MS, and IR spectroscopic data in association with previous literature were used for the characterization of all the isolated compounds. Compounds 1–4 are reported for the first time from A. klaineanum. The methanol crude extract (AK-MeOH), the n-hexane fraction (AK-Hex), the dichloromethane fraction (AK-DCM), the ethyl acetate fraction (AK-EtOAc), and compounds 1–6 were all evaluated for their antiparasitic effects against Plasmodium falciparum strains susceptible to chloroquine (3D7), resistant to chloroquine (Dd2), and promastigotes of Leishmania donovani (MHOM/SD/62/1S). The AK-Hex, AK-EtOAc, AK-MeOH, and compound 2 were strongly active against Dd2 strain with IC50 ranging from 2.78 ± 0.06 to 9.30 ± 0.29 µg/mL. Particularly, AK-MeOH was the most active—more than the reference drugs used—with an IC50 of 2.78 ± 0.06 µg/mL. The AK-EtOAc as well as all the tested compounds showed strong antileishmanial activities with IC50 ranging from 4.80 ± 0.13 to 9.14 ± 0.96 µg/mL.

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“…This phenolic compound is widely used to delay skin photoaging processes and is a photoprotective agent in skincare formulation [ 42 ]. Ferulic acid has been reported by Guetchueng et al (2020) in extracts from the stem bark of Pseudospondias macrocarpa [ 43 ]. In their study, Soxhlet extraction was used with n-hexane, dichloromethane, and methanol.…”

Section: Resultsmentioning

confidence: 99%

Ultrasound-Assisted Extraction of Phenolic Compounds from Adenaria floribunda Stem: Economic Assessment

Lopeda-Correa

Valdés-Duque

Osorio-Tobón

2022

Foods

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Adenaria floribunda is a native species found in tropical regions of South America used as a traditional medicine. Ultrasound-assisted extraction (UAE) is an extraction process known to increase the extraction yield, reduce extraction times, and use low temperatures. This study aims to obtain water-based extracts from A. floribunda stems using UAE, hot water extraction (HWE), and Soxhlet extraction and perform an economic analysis. The global extraction yield (GEY) and total phenolic compounds (TPC) of extracts ranged from 5.24% to 10.48% and from 1.9 ± 0.44 mg GAE g−1 DW to 6.38 ± 0.28 mg GAE g−1, respectively. Gallic acid, catechin, and ferulic acid were identified in the extract using HPLC-UV. Results indicate that Soxhlet extraction has the best performance regarding GEY and TPC. However, after performing an economic assessment, the cost of manufacturing (COM) of Soxhlet extraction (US$ 5.8 flask−1) was higher than the UAE (US$ 3.86 flask−1) and HWE (US$ 3.92 flask−1). The sensitivity results showed that obtaining extracts from A. floribunda by UAE and HWE is economically feasible when the selling price is above US$ 4 flask−1. Soxhlet extraction is a feasible technique when the selling price is above US$ 7 flask−1.

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Phenolic compounds from the leaves and stem bark of Pseudospondias microcarpa (A. Rich.) Engl. (Anacardiaceae)

Cited by 4 publications

References 25 publications

Antiviral and anti-inflammatory activities of chemical constituents from twigs of Mosla chinensis Maxim

Antiviral and anti-inflammatory activities of chemical constituents from twigs of Mosla chinensis Maxim

Antileishmanial and Antiplasmodial Activities of Secondary Metabolites from the Root of Antrocaryon klaineanum Pierre (Anacardiaceae)

Ultrasound-Assisted Extraction of Phenolic Compounds from Adenaria floribunda Stem: Economic Assessment

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