Phenolic Compounds from the Rhizomes of Smilax china L. and Their Anti-Inflammatory Activity

Zhong, Cheng; Hu, Deng; Hou, Lian Bing; Song, Lu Yao; Zhang, Ying Jun; Xie, Yunying; Tian, Li

doi:10.3390/molecules22040515

Cited by 22 publications

(14 citation statements)

References 19 publications

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“…Phenolic compounds are usually found in date palms, and these compounds also act as antiinflammatory agents [20]. These compounds exert their anti-inflammatory effect by inhibiting leukocyte migration and reducing serum lysozyme, NO, PGE-2, and malondialdehyde levels [7].…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory effect of date seeds (<i>Phoenix dactylifera</i> L) on carrageenan-induced edema in rats

Saryono¹,

Warsinah²,

Isworo³

et al. 2019

Trop. J. Pharm Res

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Purpose: To study the anti-inflammatory properties and mechanism of action of date seed extract in carrageenan-induced edema in rats. Methods: In this study with a pre-and post-test control group design, 30 Wistar rats were divided into six groups: Groups C1, C2, and C3 (given 1, 3, and 5 g/kg of soaked date seeds, respectively); positive control (PC, positive control given dexamethasone, 0.5 mg/kg dose), negative control (NC, edema induced by carrageenan), and healthy control (HC, no treatment). In groups C1-3, PC, and NC, carrageenan was administered intraperitoneally prior to date seed, PC and NC treatments. Prostaglandin E2 (PGE-2), cyclooxygenase (COX)-1, COX-2, interleukin (IL)-1β, and IL-12 were measured before and immdiate;y after treatment and compared between the groups. Results: Steeped date seed modulated inflammatory mediators by decreasing IL-1β, COX-1, COX-2, IL-12, and PGE-2 significantly (p < 0.05). Its indicated that the steeped date seeds down-regulate proinflammatory mediators in a manner similar to that of dexamethasone as positive control. Conclusion: Steeped date seeds possess anti-inflammatory activity similar to that of dexamethasone, through a mechanism involving decreases in pro-inflammatory mediators. Thus, date seeds is a potential source of herbal anti-inflammatory therapy.

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Section: Discussionmentioning

confidence: 99%

Anti-inflammatory effect of date seeds (<i>Phoenix dactylifera</i> L) on carrageenan-induced edema in rats

Saryono¹,

Warsinah²,

Isworo³

et al. 2019

Trop. J. Pharm Res

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“…Most of these compounds have received considerable attention as being potentially beneficial to health owing to their potent antioxidant activity as well as their hepatoprotective, hypoglycemic, and antiviral activities [ 9 ]. Recently, researchers from China reported that phenolic compounds from the rhizomes of Smilax china have anti-inflammatory activity [ 10 ]. Phenolic compounds in higher plants can be roughly divided into non-flavonoid and flavonoid compounds [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Expression of Genes Related to Phenylpropanoid Biosynthesis in Different Organs of Ixeris dentata var. albiflora

Lee

Park

et al. 2017

Molecules

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Members of the genus Ixeris have long been used in traditional medicines as stomachics, sedatives, and diuretics. Phenylalanine ammonia-lyase (PAL), cinnamate-4-hydroxylase (C4H), 4-coumarate: coenzyme-A (CoA) ligase (4CL), chalcone synthase (CHS), and dihydroflavonol 4-reductase (DFR) are important enzymes in the phenylpropanoid pathway. In this study, we analyzed seven genes from Ixeris dentata var. albiflora that are involved in phenylpropanoid biosynthesis, using an Illumina/Solexa HiSeq 2000 platform. The amino acid sequence alignments for IdPALs, IdC4H, Id4CLs, IdCHS, and IdDFR showed high identity to sequences from other plants. We also investigated transcript levels using quantitative real-time PCR, and analyzed the accumulation of phenylpropanoids in different organs of I. dentata var. albiflora using high-performance liquid chromatography. The transcript levels of IdC4H, Id4CL1, IdCHS, and IdDFR were highest in the leaf. The catechin, chlorogenic acid, ferulic acid, and quercetin contents were also highest in the leaf. We suggest that expression of IdC4H, Id4CL1, IdCHS, and IdDFR is associated with the accumulation of phenylpropanoids. Our results may provide baseline information for elucidating the mechanism of phenylpropanoid biosynthesis in different organs of I. dentata var. albiflora.

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“…LPS (the main component of the cell wall of Gram-negative bacteria) is a potent inducer of human T-lymphocyte proliferation as part of host pro-inflammatory response [ 46 ]. In addition, the anti-inflammatory properties of some phytochemicals present in HDHE have been reported [ 47 , 48 , 49 , 50 ]. The use of anti-inflammatory agents is of great importance in the treatment of microbial infection [ 51 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

Himatanthus drasticus Leaves: Chemical Characterization and Evaluation of Their Antimicrobial, Antibiofilm, Antiproliferative Activities

Figueiredo¹,

Santos²,

Castro³

et al. 2017

Molecules

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Plant-derived products have played a fundamental role in the development of new therapeutic agents. This study aimed to analyze antimicrobial, antibiofilm, cytotoxicity and antiproliferative potentials of the extract and fractions from leaves of Himatanthus drasticus, a plant from the Apocynaceae family. After harvesting, H. drasticus leaves were macerated and a hydroalcoholic extract (HDHE) and fractions were prepared. Antimicrobial tests, such as agar-diffusion, Minimum Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) were carried out against several bacterial species. Staphylococcus aureus, Pseudomonas aeruginosa, Listeria monocytogenes and Klebsiella pneumoniae were inhibited by at least one extract or fraction in the agar-diffusion assay (inhibition halos from 12 mm to 30 mm). However, the lowest MIC value was found for HDHE against K. pneumoniae. In addition, HDHE and its fractions were able to inhibit biofilm formation at sub-inhibitory concentrations (780 µg/mL and 1.56 µg/mL). As the best activities were found for HDHE, we selected it for further assays. HDHE was able to increase ciprofloxacin (CIP) activity against K. pneumoniae, displaying synergistic (initial concentration CIP + HDHE: 2 µg/mL + 600 µg/mL and 2.5 µg/mL + 500 µg/mL) and additive effects (CIP + HDHE: 3 µg/mL + 400 µg/mL). This action seems to be associated with the alteration in bacterial membrane permeability induced by HDHE (as seen by propidium iodide labeling). This extract was non-toxic for red blood cell or human peripheral blood mononuclear cells (PBMCs). Additionally, it inhibited the lipopolysaccharide-induced proliferation of PBMCs. The following compounds were detected in HDHE using HPLC-ESI-MS analysis: plumieride, plumericin or isoplumericin, rutin, quercetin and derivatives, and chlorogenic acid. Based on these results we suggest that compounds from H. drasticus have antimicrobial and antibiofilm activities against K. pneumoniae and display low cytotoxicity and anti-proliferative action in PBMC stimulated with lipopolysaccharide.

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Phenolic Compounds from the Rhizomes of Smilax china L. and Their Anti-Inflammatory Activity

Cited by 22 publications

References 19 publications

Anti-inflammatory effect of date seeds (<i>Phoenix dactylifera</i> L) on carrageenan-induced edema in rats

Anti-inflammatory effect of date seeds (<i>Phoenix dactylifera</i> L) on carrageenan-induced edema in rats

Expression of Genes Related to Phenylpropanoid Biosynthesis in Different Organs of Ixeris dentata var. albiflora

Himatanthus drasticus Leaves: Chemical Characterization and Evaluation of Their Antimicrobial, Antibiofilm, Antiproliferative Activities

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