Phenolic Compounds from Water-Ethanol Extracts ofTetrapleura tetrapteraProduced in Cameroon, as Potential Protectors againstIn VivoCCl4-Induced Liver Injuries

Abstract

Background. Liver diseases are a global health problem. Medicinal plants are being increasingly used to manage a wide variety of diseases including liver disorders. The aim of this study was to investigate the antioxidant properties and hepatoprotective activity of polyphenolic extract from the fruits ofTetrapleura tetraptera (T. tetraptera).Results. The extract ofT. tetrapterawas administered at doses of 50 mg/kg and 100 mg/kg for 07per osto rats before the induction of hepatotoxicity with of 2 ml/kg of 1:1 (v/v) carbon tetrachloride (CCl4) and olive oil through intraperitoneal route. Thein vitroantioxidant and radical scavenging properties ofT. tetrapterawere conducted by the FRAP method, the phosphomolybdate method, and the inhibition potential of DPPH, ABTS, OH, and NO radicals. The extraction yield ofT. tetrapterawas 19.35%. This extract contains polyphenols (273.48 mg CAE/g DM), flavonoids (5.2549 mg SE/g DM), and flavonols (1.615 mg SE/g DM). This extract showedin vitroantioxidant activity, an inhibitor power of various free radicals, and radical scavenging potential dose-dependent. The fifty-percent inhibitory concentration of the extract (IC50) for the studied radical varied from 28.16 to 136μg/L. In rats treated with the extract ofT. tetraptera, in a dose-dependent manner, the levels of hepatotoxicity markers such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) significantly increased while the enzyme activities of superoxide dismutase (SOD), catalase (CAT), and the level of reduced glutathione (GHS) significantly increased compared to the control group.Conclusions. The extracts from the fruit ofT. tetrapterademonstrate antioxidant activity and hepatoprotective effects.

Temperature dependent studies on nutritional, total polyphenols, flavonoids content and antioxidant activities of Aframomum citratum (C.Pereira) K.Schum and Tetrapleura tetraptera (Schum. & Thonn.) Taub. fruits

“…The results of this study showed that heat-treated T. tetraptera and the formulation contain the highest phenolic content, which correlated with the highest antioxidant potentials. This finding has already been reported by Joel et al (2017), Sokamte et al (2019) and Saague et al (2019). Several studies on spices have been reported in parallel with this finding (Khatun et al, 2006;Raj & Arulmozhi, 2013).…”

“…All of the antioxidant activities are positively and strongly (more than 90%) correlated with TPP and TFL contents, meaning that most of the observed effects are due to phenolic compounds. Previous studies (Saague et al, 2019;Sokamte et al, 2019) drew the same conclusions for the two plant species extracts. The increase in antioxidant activity may also be indicative that the neoformation of new antioxidant compounds after heat treatment is more important than the degradation of antioxidant compounds by heat.…”

Combination of metformin and luteolin synergistically protects carbon tetrachloride‐induced hepatotoxicity: Mechanism involves antioxidant, anti‐inflammatory, antiapoptotic, and Nrf2/HO‐1 signaling pathway

“…Avidin‐horseradish peroxidase conjugate was utilized to oxidize 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid), which created a chromogen whose concentration was relative to the convergence of the cytokine being assessed. The estimations were performed at 405 nm wavelength by spectrophotometry …”

A Review of Plants with Remarkable Hepatoprotective Activity

“…Alkaloids, flavonoids, steroids, triterpenoids, saponins, tannins, glycosides, and phenolic 7 Phyllanthus Fraternus Phenolic and flavonoid content 27 Pavetta Indica LINN Flavonoids and their glycosides, alkaloids, sterols, phenolics, lignins, terpenoids, coumarins,saponins,phenols 28 Mimosa Pudica Flavonoids, glycosides, terpinoids, alkaloids, phenol and tannin 10 Terminalia coriacea β -Sitosterol, Stigmasterol, 1H-Inden-1-one,2,3-dihydro-3,3,5,6,-tetramethyl, nhexadecanoic acid, flavonoids and tannins 3 Bambusa Bambos Flavonoids, steroidal alkaloids, etc 11 Rosa Canina Flavonoids, phenolic acids, tannins, carotenoids 12 Garcinia Pedunculata Flavonoids, saponins, glycosides, steroids, alkaloids and phenols 13 Tetrapleura tetraptera Flavonoid,polyphenols,flavanol 29 Feijoa sellowiana polyphenols 15 ISSN: 2250-1177…”