Phenolic profiling and antibacterial potential of Saudi Arabian native date palm (<i>Phoenix dactylifera</i>) cultivars

Mediani, Ahmed

doi:10.1080/10942912.2020.1751196

Cited by 25 publications

(14 citation statements)

References 51 publications

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“…Maltose, catechin, myricetin, quercetin, β-sitoserol, digalacturonic acid, chlorogenic acid, and β-carotene were found to be major molecules [ 37 ]. Moreover, the LC-linear ion quadrupole mass spectrometric analysis (LC-MS and LC-MS/MS tandem mass spectrometry) analysis revealed the presence of 3,30-di-O-methyl ellagic acid, 7-methoxyquercetin-O-hexose isomers, caffeic acid, ferulic acid, isomers of quercetin-rutinoside, kaempferol methylether, p-hydroxybenzoic acid, phytol, punicalagin, and quercetin-3-O-glucoside (isoquercitrin) in Ajwa [ 38 ]. The most dominant phenolic compounds in Ajwa dates, according to Hamad et al (2015) [ 39 ], were p-coumaric acid, gallic acid, and ferulic acid derivatives.…”

Section: Resultsmentioning

confidence: 99%

Role of Ajwa Date Fruit Pulp and Seed in the Management of Diseases through In Vitro and In Silico Analysis

Anwar

Raut

Alsahli

et al. 2022

Biology

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This study investigated the health-promoting activities of methanolic extracts of Ajwa date seed and fruit pulp extracts through in vitro studies. These studies confirmed potential antioxidant, anti-hemolytic, anti-proteolytic, and anti-bacterial activities associated with Ajwa dates. The EC50 values of fruit pulp and seed extracts in methanol were reported to be 1580.35 ± 0.37 and 1272.68 ± 0.27 µg/mL, respectively, in the DPPH test. The maximum percentage of hydrogen peroxide-reducing activity was 71.3 and 65.38% for both extracts at 600 µg/mL. Fruit pulp and seed extracts inhibited heat-induced BSA denaturation by 68.11 and 60.308%, heat-induced hemolysis by 63.84% and 58.10%, and hypersalinity-induced hemolysis by 61.71% and 57.27%, and showed the maximum anti-proteinase potential of 56.8 and 51.31% at 600 μg/mL, respectively. Seed and fruit pulp inhibited heat-induced egg albumin denaturation at the same concentration by 44.31 and 50.84%, respectively. Ajwa seed showed minimum browning intensity by 63.2%, percent aggregation index by 64.2%, and amyloid structure by 63.8% at 600 μg/mL. At 100 mg/mL, Ajwa seed extract exhibited good antibacterial activity. Molecular docking analysis showed that ten active constituents of Ajwa seeds bind with the critical antioxidant enzymes, catalase (1DGH) and superoxide dismutase (5YTU). The functional residues involved in such interactions include Arg72, Ala357, and Leu144 in 1DGH, and Gly37, Pro13, and Asp11 in 5YTU. Hence, Ajwa dates can be used to develop a suitable alternative therapy in various diseases, including diabetes and possibly COVID-19-associated complications.

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Section: Resultsmentioning

confidence: 99%

Role of Ajwa Date Fruit Pulp and Seed in the Management of Diseases through In Vitro and In Silico Analysis

Anwar

Raut

Alsahli

et al. 2022

Biology

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“…The potent activity was related to the active components of S. persica, including flavonoids, salvadorine, alkaloids, cyanogenic, salvadourea, glycosides, and tannins, which are known to possess strong antimicrobial activity [131][132][133]. Methanolic extracts from the leaves, stem, flower, and fruit of Conocarpus erectus L. and the leaves of Aerva javanica exhibited strong antibacterial activity against Bacillus subtilis, S. aureus, and the acid-fast bacterium Mycobacterium phlei [134][135][136]. Furthermore, the methanolic extracts of Mentha × piperita and Mentha longifolia populations grown in northern SA showed that M. × piperita contained the flavonoids naringin 328.8 mg/100 g DW, cynaroside 162.8 mg/100 g DW, and higher phenolic acid content than M. longifolia: rosmarinic acid 1547.6 mg/100 g DW, cryptochlorogenic acid 91.7 mg/100 g DW, and chlorogenic acid 69.4 mg/100 g DW.…”

Section: Antibacterial Activity Of Saudi Arabian Plants and Their Pot...mentioning

confidence: 99%

Saudi Arabian Plants: A Powerful Weapon against a Plethora of Diseases

El‐Seedi

Kotb

Musharraf

et al. 2022

Plants

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The kingdom of Saudi Arabia (SA) ranks fifth in Asia in terms of area. It features broad biodiversity, including interesting flora, and was the historical origin of Islam. It is endowed with a large variety of plants, including many herbs, shrubs, and trees. Many of these plants have a long history of use in traditional medicine. The aim of this review is to evaluate the present knowledge on the plants growing in SA regarding their pharmacological and biological activities and the identification of their bioactive compounds to determine which plants could be of interest for further studies. A systematic summary of the plants’ history, distribution, various pharmacological activities, bioactive compounds, and clinical trials are presented in this paper to facilitate future exploration of their therapeutic potential. The literature was obtained from several scientific search engines, including Sci-Finder, PubMed, Web of Science, Google Scholar, Scopus, MDPI, Wiley publications, and Springer Link. Plant names and their synonyms were validated by ‘The Plant List’ on 1 October 2021. SA is home to approximately 2247 plant species, including native and introduced plants that belong to 142 families and 837 genera. It shares the flora of three continents, with many unique features due to its extreme climate and geographical and geological conditions. As plants remain the leading supplier of new therapeutic agents to treat various ailments, Saudi Arabian plants may play a significant role in the fight against cancer, inflammation, and antibiotic-resistant bacteria. To date, 102 active compounds have been identified in plants from different sites in SA. Plants from the western and southwestern regions have been evaluated for various biological activities, including antioxidant, anti-cancer, antimicrobial, antimalarial, anti-inflammatory, anti-glycation, and cytotoxic activities. The aerial parts of the plants, especially the leaves, have yielded most of the bioactive compounds. Most bioactivity tests involve in vitro assessments for the inhibition of the growth of tumour cell lines, and several compounds with in vitro antitumour activity have been reported. More in-depth studies to evaluate the mode of action of the compounds are necessary to pave the way for clinical trials. Ecological and taxonomical studies are needed to evaluate the flora of SA, and a plan for the conservation of wild plants should be implemented, including the management of the protection of endemic plants.

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“…However, a recent study revealed the presence of phenolic compounds in the aerial parts of Wodyetia bifurcata (Sengab et al, 2015). Phenolic compounds exhibit various physiological properties such as antioxidant (Hanula et al, 2020), anti-microbial (Alshwyeh, 2020), anti-inflammatory (Sengab et al, 2015;John and Shahidi, 2019) and anti-cancer (Kim et al, 2010;Palanisamy et al, 2022a) activities.…”

Section: Introductionmentioning

confidence: 99%

Effect of agitation on extraction of phenolic compounds from ripe pericarp of Wodyetia bifurcata

Sakdasukon

Thanachasai

2022

Maejo Int. J. Energ. Environ. Comm. or MIJEEC

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In this study, the ripe pericarp extracts of Wodyetia bifurcata were prepared by solvent extraction techniques with and without agitation. The influence of agitation was examined on the extraction yield, total phenolic content (TPC), total flavonoid content (TFC) and antioxidant activity of the ripe pericarp extracts of Wodyetia bifurcata. Antioxidant capacity of extracts was evaluated by measuring the scavenging effect on 2, 2’-azinobis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and 2, 2’-diphenyl-1-picrylhydrazyl (DPPH) radicals. Compared to solvent extraction without agitation, solvent extraction with agitation significantly (p < 0.05) increased the extraction yield, TPC, TFC and antioxidant capacities (ABTS and DPPH) of the ripe pericarp extracts of Wodyetia bifurcata. In addition, higher agitation speed resulted in higher extraction yield, TPC, TFC and antioxidant activities (ABTS and DPPH) of the ripe pericarp extracts of Wodyetia bifurcata.

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Phenolic profiling and antibacterial potential of Saudi Arabian native date palm (Phoenix dactylifera) cultivars

Cited by 25 publications

References 51 publications

Role of Ajwa Date Fruit Pulp and Seed in the Management of Diseases through In Vitro and In Silico Analysis

Role of Ajwa Date Fruit Pulp and Seed in the Management of Diseases through In Vitro and In Silico Analysis

Saudi Arabian Plants: A Powerful Weapon against a Plethora of Diseases

Effect of agitation on extraction of phenolic compounds from ripe pericarp of Wodyetia bifurcata

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