Phenolic profiling and in vitro bioactivities of three medicinal Bryophyllum plants

García-Pérez, Pascual; Ayuso, Manuel; Lozano-Milo, Eva; Pereira, Carla; Días, María Inês; Ivanov, Marija; Calhelha, Ricardo C.; Sokóvić, Marina; Ferreira, Isabel C.F.R.; Barros, Lillian; Gallego, Pedro Pablo Ferrer

doi:10.1016/j.indcrop.2021.113241

Cited by 17 publications

(14 citation statements)

References 76 publications

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“…However, these results are >96% lower than those of dexamethasone, an anti-inflammatory drug used as a positive control (Table 6). The highest activity found for P. purpurea could be motivated by the high rates of phenolic compounds and carotenoids previously described, as it has been proposed by other seaweed species and terrestrial plants [44,45]. Concerning the anti-inflammatory and cytotoxic activity of seaweed extracts, results are displayed in Table 6.…”

Section: Performance Of Seaweeds As a Promising Source Of Bioactive C...mentioning

confidence: 77%

“…The highest activity found for P. purpurea could be motivated by the high rates of phenolic compounds and carotenoids previously described, as it has been proposed by other seaweed species and terrestrial plants [44,45]. In this regard, Lee [46] recently determined the anti-inflammatory mechanisms associated with Porphyra extracts, showing a multifaceted mode of action involving nitric oxide scavenging, the inhibition of proinflammatory mediators, and the induction of antioxidant enzymes.…”

Section: Performance Of Seaweeds As a Promising Source Of Bioactive C...mentioning

confidence: 84%

“…The anti-inflammatory activity of seaweed extracts was determined as a function of the inhibition of nitric oxide (NO) production by lipopolysaccharide (LPS)-induced RAW264.7 macrophages cell line, as described by Garcia-Perez [44]. For the purpose, extracts were lyophilized to obtain the dry residue, which was resuspended in water and assessed at four concentrations, ranging 0.125-0.4 mg/mL.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

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Thermochemical Characterization of Eight Seaweed Species and Evaluation of Their Potential Use as an Alternative for Biofuel Production and Source of Bioactive Compounds

Cassani

Lourenço-Lopes

Barral-Martinez

et al. 2022

IJMS

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Algae are underexplored resources in Western countries and novel approaches are needed to boost their industrial exploitation. In this work, eight edible seaweeds were subjected to their valorization in terms of nutritional characterization, thermochemical properties, and bioactive profile. Our results suggest that seaweeds present a rich nutritional profile, in which carbohydrates are present in high proportions, followed by a moderate protein composition and a valuable content of ω-3 polyunsaturated fatty acids. The thermochemical characterization of seaweeds showed that some macroalgae present a low ash content and high volatile matter and carbon fixation rates, being promising sources for alternative biofuel production. The bioactive profile of seaweeds was obtained from their phenolic and carotenoid content, together with the evaluation of their associated bioactivities. Among all the species analyzed, Porphyra purpurea presented a balanced composition in terms of carbohydrates and proteins and the best thermochemical profile. This species also showed moderate anti-inflammatory activity. Additionally, Himanthalia elongata extracts showed the highest contents of total phenolics and a moderate carotenoid content, which led to the highest rates of antioxidant activity. Overall, these results suggest that seaweeds can be used as food or functional ingredient to increase the nutritional quality of food formulations.

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Section: Performance Of Seaweeds As a Promising Source Of Bioactive C...mentioning

confidence: 77%

Section: Performance Of Seaweeds As a Promising Source Of Bioactive C...mentioning

confidence: 84%

Section: Anti-inflammatory Activitymentioning

confidence: 99%

See 1 more Smart Citation

Thermochemical Characterization of Eight Seaweed Species and Evaluation of Their Potential Use as an Alternative for Biofuel Production and Source of Bioactive Compounds

Cassani

Lourenço-Lopes

Barral-Martinez

et al. 2022

IJMS

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“…(Lashusa) is the most notable phytoconstituent responsible for the therapeutic efficacy [ 75 ]. Vanillic acid, nepetin, verbascoside, and hispidulin, of Clerodendrum petasites S. Moore (CP) were chosen as potential phenolic active compounds in Thai traditional medicine for the treatment of different kinds of skin diseases [ 76 , 77 , 78 ]. Bouyahya et al [ 79 ] reported that compounds such as terpenoids, alkaloids, flavonoids, phenolic acids, and fatty acids of Arbutus unedo L., Thymus capitatus managed diabetes by several mechanisms such as enzymatic inhibition, interference with glucose and lipid metabolism signaling pathways, and the inhibition and the activation of gene expression involved in glucose homeostasis.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

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Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical and medicinal sections to promote human health and prevent and cure different diseases. The most common flavonoids found in nature are anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, and other sub-classes. The impacts of plant flavonoids and other phenolics on human health promoting and diseases curing and preventing are antioxidant effects, antibacterial impacts, cardioprotective effects, anticancer impacts, immune system promoting, anti-inflammatory effects, and skin protective effects from UV radiation. This work aims to provide an overview of phenolic compounds and flavonoids as potential and important sources of pharmaceutical and medical application according to recently published studies, as well as some interesting directions for future research. The keyword searches for flavonoids, phenolics, isoflavones, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, and secoiridoids medicinal plant were performed by using Web of Science, Scopus, Google scholar, and PubMed. Phenolic acids contain a carboxylic acid group in addition to the basic phenolic structure and are mainly divided into hydroxybenzoic and hydroxycinnamic acids. Hydroxybenzoic acids are based on a C6-C1 skeleton and are often found bound to small organic acids, glycosyl moieties, or cell structural components. Common hydroxybenzoic acids include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, and salicylic acids. Hydroxycinnamic acids are based on a C6-C3 skeleton and are also often bound to other molecules such as quinic acid and glucose. The main hydroxycinnamic acids are caffeic, p-coumaric, ferulic, and sinapic acids.

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“…Bryophyllum spp. medicinal properties are a consequence of the production of phenolic compounds as recently established [4][5][6]. Thus, different extracts from Bryophyllum have been reported to exhibit valuable health-promoting properties because of the high contents of phenolic compounds, as determined through different in vitro assays.…”

Section: Introductionmentioning

confidence: 99%

The Combination of Untargeted Metabolomics and Machine Learning Predicts the Biosynthesis of Phenolic Compounds in Bryophyllum Medicinal Plants (Genus Kalanchoe)

García-Pérez

Zhang

Miras-Moreno

et al. 2021

Plants

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Phenolic compounds constitute an important family of natural bioactive compounds responsible for the medicinal properties attributed to Bryophyllum plants (genus Kalanchoe, Crassulaceae), but their production by these medicinal plants has not been characterized to date. In this work, a combinatorial approach including plant tissue culture, untargeted metabolomics, and machine learning is proposed to unravel the critical factors behind the biosynthesis of phenolic compounds in these species. The untargeted metabolomics revealed 485 annotated compounds that were produced by three Bryophyllum species cultured in vitro in a genotype and organ-dependent manner. Neurofuzzy logic (NFL) predictive models assessed the significant influence of genotypes and organs and identified the key nutrients from culture media formulations involved in phenolic compound biosynthesis. Sulfate played a critical role in tyrosol and lignan biosynthesis, copper in phenolic acid biosynthesis, calcium in stilbene biosynthesis, and magnesium in flavanol biosynthesis. Flavonol and anthocyanin biosynthesis was not significantly affected by mineral components. As a result, a predictive biosynthetic model for all the Bryophyllum genotypes was proposed. The combination of untargeted metabolomics with machine learning provided a robust approach to achieve the phytochemical characterization of the previously unexplored species belonging to the Bryophyllum subgenus, facilitating their biotechnological exploitation as a promising source of bioactive compounds.

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Phenolic profiling and in vitro bioactivities of three medicinal Bryophyllum plants

Cited by 17 publications

References 76 publications

Thermochemical Characterization of Eight Seaweed Species and Evaluation of Their Potential Use as an Alternative for Biofuel Production and Source of Bioactive Compounds

Thermochemical Characterization of Eight Seaweed Species and Evaluation of Their Potential Use as an Alternative for Biofuel Production and Source of Bioactive Compounds

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

The Combination of Untargeted Metabolomics and Machine Learning Predicts the Biosynthesis of Phenolic Compounds in Bryophyllum Medicinal Plants (Genus Kalanchoe)

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