Phenotypes and Genotypes in Postherpetic Neuralgia Drug Therapy

Anosike, Udochukwu Godswill; Ouko, Innocent; Mwaura, Anita Wambui; Ongidi, Ibsen; Mbonu, Chijioke Chukwukaelo

doi:10.1097/ajp.0000000000001045

Cited by 6 publications

(5 citation statements)

References 57 publications

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“… 57–59 In addition, genetic factors are also critically associated with pathogenesis, and several researches have indicated specific genetic variants associated with an elevated risk of PHN, suggesting a genetic predisposition to the condition. 60–62 …”

Section: Discussionmentioning

confidence: 99%

“…[57][58][59] In addition, genetic factors are also critically associated with pathogenesis, and several researches have indicated specific genetic variants associated with an elevated risk of PHN, suggesting a genetic predisposition to the condition. [60][61][62] When cells are damaged, infected, or invaded, and inflammation occurs, monocytes, macrophages, and other nonimmune cells, such as fibroblasts and endothelial cells, release a cytokine called interleukin-1 beta (IL-1β). Recent literature has revealed that injured dorsal root ganglion (DRG) neurons also express IL-1β.…”

Section: Discussionmentioning

confidence: 99%

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Humoral Cytokine Levels in Patients with Herpes Zoster: A Meta-Analysis

Yue,

Yao

2024

JPR

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Background The neurocutaneous disease caused by the reactivation of varicella-zoster virus (VZV) is called herpes zoster (HZ). The virus remains in the spinal cord back root after the chickenpox disappears. Diminished immune function can reactivate VZV, causing severe neuropathic pain that can last for months or even years, leading to postherpetic neuralgia (PHN), which severely affects the patient’s quality of life. Much literature compares various cytokine levels in the body fluids HZ and PHN patients; however, no studies comprehensively evaluate them. Methods The Cochrane Library, PubMed, Web of Science, and Medline were screened for studies on cytokine levels in body fluids of HZ and PHN patients in the English language. Healthy individuals were selected as the control group, and the standardized mean difference (SMD) between the case and control groups was imputed using a fixed-effects or random-effects model and expressed as a 95% confidence interval (CI). The Newcastle-Ottawa Scale (NOS) was used to assess article quality. Results This meta-analysis included 13 articles with 1373 participants. Compared with the control group, the HZ group had significantly higher levels of interleukin (IL)-4, IL-6, IL-10, Hcy, and C-reactive protein (CRP), whereas the levels of CD3+ T and CD4+ T lymphocytes were reduced. Additionally, PHN patients had significantly higher levels of IL-6 and IL-1β compared with the control group. Conclusion This meta-analysis provides compelling evidence that CRP, Hcy, IL-1β, IL-4, IL-6, IL-8, and IL-10 are associated with the genesis and development of HZ and PHN. These markers can be used to improve the diagnosis and treatment of these diseases.Furthermore, for making the results more convincing, it is necessary to harmonize sample acquisition techniques and analytical methods and also require larger, more rigorously designed studies with broader subgroups and sex/age-matched controls.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Humoral Cytokine Levels in Patients with Herpes Zoster: A Meta-Analysis

Yue,

Yao

2024

JPR

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“…Lastly, genetic factors may also influence the development of PHN. Several studies have identified specific genetic variants that are associated with an increased risk of developing PHN, suggesting a genetic predisposition to the disorder ( 51 – 53 ).…”

Section: Discussionmentioning

confidence: 99%

Bidirectional two-sample Mendelian randomization analysis reveals a causal effect of interleukin-18 levels on postherpetic neuralgia risk

Xiao

Fan

2023

Front. Immunol.

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BackgroundPostherpetic neuralgia (PHN) is a debilitating complication of herpes zoster, characterized by persistent neuropathic pain that significantly impairs patients’ quality of life. Identifying factors that determine PHN susceptibility is crucial for its management. Interleukin-18 (IL-18), a pro-inflammatory cytokine implicated in chronic pain, may play a critical role in PHN development.MethodsIn this study, we conducted bidirectional two-sample Mendelian randomization (MR) analyses to assess genetic relationships and potential causal associations between IL-18 protein levels increasing and PHN risk, utilizing genome-wide association study (GWAS) datasets on these traits. Two IL-18 datasets obtained from the EMBL’s European Bioinformatics Institute database which contained 21,758 individuals with 13,102,515 SNPs and Complete GWAS summary data on IL-18 protein levels which contained 3,394 individuals with 5,270,646 SNPs. The PHN dataset obtained from FinnGen biobank had 195,191 individuals with 16,380,406 SNPs.ResultsOur findings from two different datasets of IL-18 protein levels suggest a correlation between genetically predicted elevations in IL-18 protein levels and an increased susceptibility to PHN.(IVW, OR and 95% CI: 2.26, 1.07 to 4.78; p = 0.03 and 2.15, 1.10 to 4.19; p =0.03, respectively), potentially indicating a causal effect of IL-18 protein levels increasing on PHN risk. However, we did not detect any causal effect of genetic liability to PHN risk on IL-18 protein levels.ConclusionThese findings suggest new insights into identifying IL-18 protein levels increasing at risk of developing PHN and may aid in the development of novel prevention and treatment approaches for PHN.

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“…Esketamine has an anti-depressant effect by increasing extracellular glutamate and mTORC1-dependent synapse formation (Shinohara et al, 2021). Anticonvulsants and antidepressants are clinically first-line drugs for the treatment of PHN, which are effective to treat PHN and alleviate patients' depressive mood due to pain (Anosike et al, 2022). It should be taken into account that the long-term use of esketamine is addictive, limiting its application in treating chronic PHN.…”

Section: Potential Drugsmentioning

confidence: 99%

Potential novel therapeutic strategies for neuropathic pain

Zhang

Han

et al. 2023

Front. Mol. Neurosci.

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PurposeTo explore the potential therapeutic strategies of different types of neuropathic pain (NP) and to summarize the cutting-edge novel approaches for NP treatment based on the clinical trials registered on ClinicalTrials.gov.MethodsThe relevant clinical trials were searched using ClinicalTrials.gov Dec 08, 2022. NP is defined as a painful condition caused by neurological lesions or diseases. All data were obtained and reviewed by the investigators to confirm whether they were related to the current topic.ResultsA total of 914 trials were included in this study. They were divided into painful diabetic neuropathy (PDN), postherpetic neuralgia (PHN), sciatica (SC), peripheral nerve injury-related NP (PNI), trigeminal neuralgia (TN), chemotherapy-induced NP (CINP), general peripheral NP (GPNP) and spinal cord injury NP (SCI-NP). Potential novel therapeutic strategies, such as novel drug targets and physical means, were discussed for each type of NP.ConclusionNP treatment is mainly dominated by drug therapy, and physical means have become increasingly popular. It is worth noting that novel drug targets, new implications of conventional medicine, and novel physical means can serve as promising strategies for the treatment of NP. However, more attention needs to be paid to the challenges of translating research findings into clinical practice.

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Phenotypes and Genotypes in Postherpetic Neuralgia Drug Therapy

Cited by 6 publications

References 57 publications

Humoral Cytokine Levels in Patients with Herpes Zoster: A Meta-Analysis

Humoral Cytokine Levels in Patients with Herpes Zoster: A Meta-Analysis

Bidirectional two-sample Mendelian randomization analysis reveals a causal effect of interleukin-18 levels on postherpetic neuralgia risk

Potential novel therapeutic strategies for neuropathic pain

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