2024
DOI: 10.1128/mbio.00736-24
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Phenotypic and transcriptional changes in peripheral blood mononuclear cells during alphavirus encephalitis in mice

Benjamin H. Nguyen,
Maggie L. Bartlett,
Elizabeth M. Troisi
et al.

Abstract: Sindbis virus (SINV) infection of mice provides a model system for studying the pathogenesis of alphaviruses that infect the central nervous system (CNS) to cause encephalomyelitis. While studies of human viral infections typically focus on accessible cells from the blood, this compartment is rarely evaluated in mice. To bridge this gap, single-cell RNA sequencing (scRNAseq) was combined with flow cytometry to characterize the transcriptional and phenotypic changes of peripheral blood mononuclear cells (PBMCs)… Show more

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