Phenotypic testicular abnormalities and pubertal development in boys with McCune-Albright syndrome

Aversa, Tommaso; Zirilli, Giuseppina; Corica, Domenico; Luca, Filippo De; Waśniewska, Małgorzata

doi:10.1186/s13052-018-0577-7

Cited by 4 publications

(3 citation statements)

References 22 publications

(56 reference statements)

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“…Testicular autonomous hyperfuction in MAS may also be secondary to Sertoli cells activation with a consequent isolated macroorchidism usually not followed by signs of sexual precocity and prepubertal testosterone levels ( 30 , 31 ). A higher incidence of testicular abnormalities on ultrasound (microlithiasis, hypoecoic lesions, focal calcifications) has also been described ( 33 , 50 , 51 ) ( Figure 1B ). None of the patients with these lesions, followed up for several years, developed any signs of malignant transformation, so a conservative approach has been recommended ( 33 ).…”

Section: Endocrinological Featuresmentioning

confidence: 77%

“…Few data about the natural evolution of sexual development and the adult fertility prognosis in male patients can be recovered. According to available data, males seemed to be able to maintain their autonomous testicular function ( 33 , 64 ).…”

Section: Long-term Health Problemsmentioning

confidence: 99%

“…A higher incidence of testicular abnormalities on ultrasound (microlithiasis, hypoecoic lesions, focal calcifications) has also been described (33, 50, 51) (Figure 1B). None of the patients with these lesions, followed up for several years, developed any signs of malignant transformation, so a conservative approach has been recommended (33).…”

Section: Endocrinological Features Precocious Pubertymentioning

confidence: 99%

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Auxological and Endocrinological Features in Children With McCune Albright Syndrome: A Review

Tufano¹,

Ciofi

Amendolea³

et al. 2020

Front. Endocrinol.

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McCune–Albright syndrome is a rare and challenging congenital sporadic disease involving the skin and skeletal and endocrine systems with a prevalence ranges from one in 100,000 to 1,000,000. In addition to the classical triad of fibrous dysplasia of bone, café au lait pigmented skin lesions and precocious puberty, other multiple endocrinological features, including hyperthyroidism, growth hormone excess, hypercortisolism, and hypophosphatemic rickets, have been reported. A brief review of the syndrome in children is here reported.

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Section: Endocrinological Featuresmentioning

confidence: 77%

Section: Long-term Health Problemsmentioning

confidence: 99%

Section: Endocrinological Features Precocious Pubertymentioning

confidence: 99%

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Auxological and Endocrinological Features in Children With McCune Albright Syndrome: A Review

Tufano¹,

Ciofi

Amendolea³

et al. 2020

Front. Endocrinol.

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Acromegaly and male sexual health

Salvio

Martino

Balercia

et al. 2022

Rev Endocr Metab Disord

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Acromegaly is a rare pathology characterized by chronic hypersecretion of Growth Hormone (GH) and Insulin-like Growth Factor-1 (IGF-1) that causes somatic, metabolic, and systemic changes. The somatotropic axis acts physiologically favoring gonadal function, but when GH is produced in excess it has deleterious effects on many aspects of male sexuality. It is widely demonstrated, in fact, that acromegaly induces hypogonadism through different mechanisms, both through direct mass effect on gonadotropic cells and through increased plasma levels of prolactin. Moreover, hypogonadism is also one of the factors linking acromegaly to erectile dysfunction (ED), but also metabolic complications of acromegaly and, probably, GH itself contribute to the genesis of this disorder. There are few data in the literature on the impact of the disease on fertility and testicular volume. Finally, knowledge of the role of GH hypersecretion on the occurrence of prostatic diseases such as benign prostatic hypertrophy and prostatic cancer appears to be of fundamental clinical importance in the long-term management of these patients.

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“Management of andrological disorders from childhood and adolescence to transition age: guidelines from the Italian Society of Andrology and Sexual Medicine (SIAMS) in collaboration with the Italian Society for Pediatric Endocrinology and Diabetology (SIEDP)—Part-1”

Bonomi,

Cangiano,

Cianfarani

et al. 2024

J Endocrinol Invest

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Purpose Andrological pathologies in the adulthood are often the results of conditions that originate during childhood and adolescence and sometimes even during gestation and neonatal period. Unfortunately, the reports in the literature concerning pediatric andrological diseases are scares and mainly concerning single issues. Furthermore, no shared position statement are so far available. Methods The Italian Society of Andrology and Sexual Medicine (SIAMS) commissioned an expert task force involving the Italian Society of Pediatric Endocrinology and Diabetology (SIEDP) to provide an updated guideline on the diagnosis and management of andrological disorders from childhood and adolescence to transition age. Derived recommendations were based on the grading of recommendations, assessment, development, and evaluation (GRADE) system. Results A literature search of articles in English for the term “varicoceles”, “gynecomastia”, “fertility preservation”, “macroorchidism”, “precocious puberty” and “pubertal delay” has been performed. Three major aspects for each considered disorder were assessed including diagnosis, clinical management, and treatment. Recommendations and suggestions have been provided for each of the mentioned andrological disorders. Conclusions These are the first guidelines based on a multidisciplinary approach that involves important societies related to the field of andrological medicine from pediatric to transition and adult ages. This fruitful discussion allowed for a general agreement on several recommendations and suggestions to be reached, which can support all stakeholders in improving andrological and general health of the transitional age.

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Phenotypic testicular abnormalities and pubertal development in boys with McCune-Albright syndrome

Cited by 4 publications

References 22 publications

Auxological and Endocrinological Features in Children With McCune Albright Syndrome: A Review

Auxological and Endocrinological Features in Children With McCune Albright Syndrome: A Review

Acromegaly and male sexual health

“Management of andrological disorders from childhood and adolescence to transition age: guidelines from the Italian Society of Andrology and Sexual Medicine (SIAMS) in collaboration with the Italian Society for Pediatric Endocrinology and Diabetology (SIEDP)—Part-1”

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