Phenotyping the Prediabetic Population—A Closer Look at Intermediate Glucose Status and Cardiovascular Disease

Barbu, E. Magda; Popescu, Mara; Popescu, Andreea-Catarina; Balanescu, Serban-Mihai

doi:10.3390/ijms22136864

Cited by 8 publications

(11 citation statements)

References 126 publications

(167 reference statements)

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“…HbA1c measurement had 49% sensitivity and 79% specificity for pre-diabetes, while FBG had 25% sensitivity and 94% specificity. HbA1C alone identified 14% of individuals diagnosed with impaired glucose tolerance (IGT), 9% with impaired fasting glycemia, and 33% with both disorders [24]. In this study, there is a discrepancy between the results of the HbA1C examination with the results of FBG and postprandial blood glucose.…”

Section: Discussionmentioning

confidence: 73%

Correlation between Insulin Resistance with Soluble CD40 Ligand and Plasminogen Activator Inhibitor-1 Plasma in Pre-diabetic Patients

Decroli

Afriant

Kam

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: The main condition of pre-diabetes is insulin resistance that can lead to a prothrombotic state. AIM: This study aims to correlate insulin resistance with soluble CD40 ligand (sCD40L) and plasminogen activator inhibitor-1 (PAI-1) plasma in pre-diabetic patients. METHODS: This study is an analytic observational study with a cross-sectional approach. HOMA-IR assessed insulin resistance, and prothrombotic factors were assessed by PAI-1 and soluble CD40L. PAI-1 and sCD40L were examined by ELISA. These indicators were assessed on 30 pre-diabetic patients. RESULTS: Thirty subjects included in this study with a mean age of 31.47 (5.03) years old, consist of 19 (63%) men and 11 (37%) women. The mean HOMA-IR was 3.69 (1.12), PAI-1 was 10.25 (3.72) ng/mL, and the PAI-1 levels were increased (>8.4 ng/mL) in 70% of the subjects. The mean of sCD40L levels was 4495.7 (1136.3) pg/ml, and sCD40L levels were increased (>4000 pg/ml) in 63% of subject. There was a significant correlation between HOMA-IR levels and sCD40L (r = 0.636, p < 0.05) and between of HOMA-IR and PAI-1 (r = 0.742, p < 0.05). Moderate correlation was found between sCD40L levels and plasma PAI-1 (r = 0.592, p < 0.05) in pre-diabetic patient. The correlation between three variables was HOMA-IR had a significant effect on PAI-1 levels through sCD40L (t = 2.010, p < 0.05, structure loading factor = 0.286). CONCLUSION: Insulin resistance has a strong and significant correlation with sCD40L and PAI-1 levels in pre-diabetic patients.

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Section: Discussionmentioning

confidence: 73%

Correlation between Insulin Resistance with Soluble CD40 Ligand and Plasminogen Activator Inhibitor-1 Plasma in Pre-diabetic Patients

Decroli

Afriant

Kam

et al. 2022

Open Access Maced J Med Sci

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“…There was no doubt that prevention approaches in Chinese individuals should differ from those advocated in other populations currently ( 4 ). The precise knowledge of prediabetes was not only helpful to distinguish people who might develop prediabetes from those who might not ( 15 ) but also contribute to self-identification and self-management. Thus, targeted and regular screening for people at high risk of prediabetes could be cost saving than universal screening ( 13 , 14 ).…”

Section: Discussionmentioning

confidence: 99%

“…Thus, personalized interventions targeting these factors and measures were needed among Chinese adults. Obviously, the prediabetic population was far from being homogeneous, and phenotyping it into less heterogeneous groups might prove useful for long-term risk assessment, follow-up, and primary prevention ( 15 ). Several merits of our study deserve to be pointed.…”

Section: Discussionmentioning

confidence: 99%

“…To halt the epidemic of diabetes, we need to target those at risk of developing prediabetes and steer effective strategies, which premises from understanding the characteristics of individuals at “high-risk” systematically. Even though the new thresholds for defining prediabetes have been around for more than 10 years, there is still controversy surrounding the precise characterization of prediabetic population ( 15 ). To date, little is known about the prediabetic conditions, and some knowledge of prediabetes gaps still remains in China ( 16 ), especially with regard to the potentially different characteristics of prediabetic subgroups classified by impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or elevated glycosylated hemoglobin (HbA1c), in which more tailored and adjusted advices for interventions could be needed.…”

Section: Introductionmentioning

confidence: 99%

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Factors correlated with targeted prevention for prediabetes classified by impaired fasting glucose, impaired glucose tolerance, and elevated HbA1c: A population-based longitudinal study

Zhu

Yang

et al. 2022

Front. Endocrinol.

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BackgroundThere is still controversy surrounding the precise characterization of prediabetic population. We aim to identify and examine factors of demographic, behavioral, clinical, and biochemical characteristics, and obesity indicators (anthropometric characteristics and anthropometric prediction equation) for prediabetes according to different definition criteria of the American Diabetes Association (ADA) in the Chinese population.MethodsA longitudinal study consisted of baseline survey and two follow-ups was conducted, and a pooled data were analyzed. Prediabetes was defined as either impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or elevated glycosylated hemoglobin (HbA1c) according to the ADA criteria. Robust generalized estimating equation models were used.ResultsA total of 5,713 (58.42%) observations were prediabetes (IGT, 38.07%; IGT, 26.51%; elevated HbA1c, 23.45%); 9.66% prediabetes fulfilled all the three ADA criteria. Among demographic characteristics, higher age was more evident in elevated HbA1c [adjusted OR (aOR)=2.85]. Female individuals were less likely to have IFG (aOR=0.70) and more likely to suffer from IGT than male individuals (aOR=1.41). Several inconsistency correlations of biochemical characteristics and obesity indicators were detected by prediabetes criteria. Body adiposity estimator exhibited strong association with prediabetes (D10: aOR=4.05). For IFG and elevated HbA1c, the odds of predicted lean body mass exceed other indicators (D10: aOR=3.34; aOR=3.64). For IGT, predicted percent fat presented the highest odds (D10: aOR=6.58).ConclusionSome correlated factors of prediabetes under different criteria differed, and obesity indicators were easily measured for target identification. Our findings could be used for targeted intervention to optimize preventions to mitigate the obviously increased prevalence of diabetes.

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“…Preventive methods for the development of type 2 diabetes after gestational diabetes have been studied, and metformin is effective in preventing the occurrence of a metabolic syndrome and may have benefits in early treatment before weight gain or insulin resistance development. The American Diabetes Association recommends metformin use for women with prior gestational diabetes [79,80].…”

Section: Gestational Diabetesmentioning

confidence: 99%

Pregnancy Complications Can Foreshadow Future Disease—Long-Term Outcomes of a Complicated Pregnancy

et al. 2021

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During gestation, the maternal body should increase its activity to fulfil the demands of the developing fetus as pregnancy progresses. Each maternal organ adapts in a unique manner and at a different time during pregnancy. In an organ or system that was already vulnerable before pregnancy, the burden of pregnancy can trigger overt clinical manifestations. After delivery, symptoms usually reside; however, in time, because of the age-related metabolic and pro-atherogenic changes, they reappear. Therefore, it is believed that pregnancy acts as a medical stress test for mothers. Pregnancy complications such as gestational hypertension, preeclampsia and gestational diabetes mellitus foreshadow cardiovascular disease and/or diabetes later in life. Affected women are encouraged to modify their lifestyle after birth by adjusting their diet and exercise habits. Blood pressure and plasmatic glucose level checking are recommended so that early therapeutic intervention can reduce long-term morbidity. Currently, the knowledge of the long-term consequences in women who have had pregnancy-related syndromes is still incomplete. A past obstetric history may, however, be useful in determining the risk of diseases later in life and allow timely intervention.

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Phenotyping the Prediabetic Population—A Closer Look at Intermediate Glucose Status and Cardiovascular Disease

Cited by 8 publications

References 126 publications

Correlation between Insulin Resistance with Soluble CD40 Ligand and Plasminogen Activator Inhibitor-1 Plasma in Pre-diabetic Patients

Correlation between Insulin Resistance with Soluble CD40 Ligand and Plasminogen Activator Inhibitor-1 Plasma in Pre-diabetic Patients

Factors correlated with targeted prevention for prediabetes classified by impaired fasting glucose, impaired glucose tolerance, and elevated HbA1c: A population-based longitudinal study

Pregnancy Complications Can Foreshadow Future Disease—Long-Term Outcomes of a Complicated Pregnancy

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