Phenyl Substituted Thiazole Linked 1, 2, 4-triazole Derivatives: Synthesis and Their Biological Evaluation

Abstract

: Some phenyl substituted thiazole linked 1, 2, 4- triazole derivatives (8a-8j) were synthesized and elucidated their structures using different spectroscopic data of IR, 1HNMR, 13CNMR & mass spectroscopy. These synthesized derivatives were evaluated for their antibacterial activity using broth dilution assay. Further, mechanism of action of test compounds was examined using protein leakage assay. Amongst all compound 8c showed most potent activity with lowest IC50 values 180 μM and 120 μM against S. aureus & B. cereus respectively whereas compound 8j demonstrated strong inhibitory activities only against negative strains P. aeruginosa and E. coli with lowest IC50 values 240 μM and 200μM respectively.