Phenylalanine-based fibrillar systems

Kuila, Soumen; Dey, Sukantha; Singh, Pijush; Shrivastava, Akash; Nanda, Jayanta

doi:10.1039/d3cc04138g

Chem. Commun.

2023

DOI: 10.1039/d3cc04138g

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Phenylalanine-based fibrillar systems

Soumen Kuila,

Sukantha Dey,

Pijush Singh

et al.

Abstract: In this feature article, we discuss the formation of long-range, ordered, amyloid-like fibrils from native phenylalanine molecules in aqueous and organic media and the inhibition of toxic fibrils by using various potent therapeutic agents.

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Cited by 2 publications

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Supramolecular J‐ and H‐Aggregation of Naphthalimide‐Conjugated Dipeptide in Mixed‐Solvent Systems and its Application in Cell Imaging

Kuila,

Reddy,

Dasgupta

et al. 2024

Chemistry An Asian Journal

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In this work, a core substituted NMI‐conjugated dipeptide (4MNLV) was extensively studied in mixed solvent systems to explore the polarity effect on the self‐assembly pattern and their photophysical property. 4MNLV adopted a J‐ or H‐ type aggregation pattern depending upon the polarity index of the solvent system chosen. The self‐assembly process was achieved through the anti‐solvent effect. UV‐vis study suggested that if the stock solution of 4MNLV was diluted with a relatively more polar solvent (compared to the stock solvent), then the system acquired J‐ type of aggregation pattern by showing a red‐shift in their absorption maxima (λmax). Conversely, when the stock was diluted by a relatively less polar solvent, H‐type of aggregation was observed where blue shift of λmax was noticed. The emission spectra and the lifetime of the self‐assembled materials were also influenced by the chosen solvent system. The chirotopic behaviour of these self‐assembled materials was studied through CD spectroscopy. Morphological study indicated the formation of helical nanofibrillar structures. The bright green fluorescence of these highly biocompatible naphthalimide‐peptide conjugate was used for cell imaging application, indicating its futuristic scope.

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Supramolecular J‐ and H‐Aggregation of Naphthalimide‐Conjugated Dipeptide in Mixed‐Solvent Systems and its Application in Cell Imaging

Kuila,

Reddy,

Dasgupta

et al. 2024

Chemistry An Asian Journal

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Programmed self-assembly of conjugated oligomer-based helical nanofibres through hydrogen bonding interactions

Wang,

Yin,

Cheraku

et al. 2025

Mater. Adv.

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Phenylalanine-based fibrillar systems

Abstract: In this feature article, we discuss the formation of long-range, ordered, amyloid-like fibrils from native phenylalanine molecules in aqueous and organic media and the inhibition of toxic fibrils by using various potent therapeutic agents.

Cited by 2 publications

References 130 publications

Supramolecular J‐ and H‐Aggregation of Naphthalimide‐Conjugated Dipeptide in Mixed‐Solvent Systems and its Application in Cell Imaging

Supramolecular J‐ and H‐Aggregation of Naphthalimide‐Conjugated Dipeptide in Mixed‐Solvent Systems and its Application in Cell Imaging

Programmed self-assembly of conjugated oligomer-based helical nanofibres through hydrogen bonding interactions

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