Phenylalanine-coupled solid lipid nanoparticles for brain tumor targeting

Dual Drug Delivery Using Lactic Acid Conjugated SLN for Effective Management of Neurocysticercosis

“…SEM confirmed the smoothness of SLN's surface even after coupling with LA. There was slight increase in size of SLN-LA as compared to SLN due to surface oriented LA (13).…”

“…on the luminal side of the BBB and degrading ecto-or endo-enzymes of the cytoplasm of endothelial cells prior to penetration into the brain (12). SLNs composed of biodegradable saturated lipids like HSPC are found to be biocompatible (13,14) and prolong blood circulation life because of enhanced in vivo stability (15,16). Pioneering characteristics of SLNs also extend many advantages such as controlled drug release (17), drug targeting and low biotoxicity, high drug payload, easy scale up, and amenability to sterilization (18,19).…”

Fucose decorated solid-lipid nanocarriers mediate efficient delivery of methotrexate in breast cancer therapeutics

“…SLNs-MTX was prepared using hot homogenization technique (Scheme 1) [33,34]. The high velocity stirring was employed to acquire a pre-emulsion phase.…”

“…Tween-80 minimizes the surface tension between aqueous and organic phases that allowed the configuration of initially tiny droplets of solvent at the site of solvent injection and thereby led a decrease in particle size. Moreover, Tween 80 was used in this study which is known to provide steric stability to achieving stable formulation [34]..…”

Galactose engineered solid lipid nanoparticles for targeted delivery of doxorubicin

“…Moreover the Tween-80 might also help to stabilize the recently generated surfaces and particle aggregation [46].…”