Phenylpropanoids, Eugenol Scaffold, and Its Derivatives as Anticancer

Fadilah, Fadilah; Yanuar, Arry; Arsianti, Ade; Andrajati, Retnosari

doi:10.22159/ajpcr.2017.v10i3.16071

Cited by 16 publications

(5 citation statements)

References 40 publications

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“…Eugenol has shown potential anticancer activity against colon, gastric, breast, prostate, and skin cancer, as well as melanoma and leukemia [23]. Eugenol inhibits tumor proliferation and formation, increases reactive oxygen species (ROS), generates apoptosis, and has a genotoxic effect in different cancer cells [23,[29][30][31]. El-Saber Batiha, G. et al [4] collected information related to Eugenol Pharmacokinetic and Toxicity Studies.…”

Section: Eugenolmentioning

confidence: 99%

Clove Essential Oil (Syzygium aromaticum L. Myrtaceae): Extraction, Chemical Composition, Food Applications, and Essential Bioactivity for Human Health

et al. 2021

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Clove (Syzygium aromaticum L. Myrtaceae) is an aromatic plant widely cultivated in tropical and subtropical countries, rich in volatile compounds and antioxidants such as eugenol, β-caryophyllene, and α-humulene. Clove essential oil has received considerable interest due to its wide application in the perfume, cosmetic, health, medical, flavoring, and food industries. Clove essential oil has biological activity relevant to human health, including antimicrobial, antioxidant, and insecticidal activity. The impacts of the extraction method (hydrodistillation, steam distillation, ultrasound-assisted extraction, microwave-assisted extraction, cold pressing, and supercritical fluid extraction) on the concentration of the main volatile compounds in clove essential oil and organic clove extracts are shown. Eugenol is the major compound, accounting for at least 50%. The remaining 10–40% consists of eugenyl acetate, β-caryophyllene, and α-humulene. The main biological activities reported are summarized. Furthermore, the main applications in clove essential oil in the food industry are presented. This review presents new biological applications beneficial for human health, such as anti-inflammatory, analgesic, anesthetic, antinociceptive, and anticancer activity. This review aims to describe the effects of different methods of extracting clove essential oil on its chemical composition and food applications and the biological activities of interest to human health.

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Section: Eugenolmentioning

confidence: 99%

Clove Essential Oil (Syzygium aromaticum L. Myrtaceae): Extraction, Chemical Composition, Food Applications, and Essential Bioactivity for Human Health

et al. 2021

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“…Cloves may also help your liver work better. Some studies have shown that eugenol found in cloves can also help reduce signs of liver cirrhosis and fatty liver disease [66][67][68].…”

Section: Nutrients Per Servingmentioning

confidence: 99%

Studies Studies on the phytochemicals of clove and their biological activities

Hema Krishna

2024

IJAC

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Cloves are a fragrant spice made from the dried flowers of the clove tree. In the past, spices used to be worth their weight in gold, and cloves were no exception. Today, cloves remain a popular spice that gives many dishes subtly sweet warmth. A drop of clove oil is 400 times more powerful as an anti-oxidant than wolf berries or blueberries. Cloves contain a lot of manganese, a mineral that helps your body manage the enzymes that help repair your bones and make hormones. Manganese can also act as an antioxidant that protects your body from harmful free radicals (unstable atoms that cause cell damage). Cloves are a fragrant, dense spice that can be added to both savory dishes (such as curries) and sweet desserts (such as pumpkin pie). They're full of powerful nutrients that help protect your cells from damage. Some natural compounds in cloves interfere with medicines or cause side effects that can be life-threatening. So, it's safest to only cook or bake with cloves and enjoy this spice's health benefits that way. Clove is utilized in cosmetics, medicine, gastronomy, and agriculture due to its abundance of bioactive components such as gallic acid, flavonoids, eugenol acetate, and eugenol. Clove essential oil has been revealed to have antibacterial, antinociceptive, antibacterial activities, antifungal, and anticancerous qualities. Anti-inflammatory chemicals, including eugenol and flavonoids, are found in clove that help decrease inflammation and alleviate pain. The anti-inflammatory and analgesic qualities of clove oil have made it a popular natural cure for toothaches and gum discomfort. Due to its therapeutic potential, it has been used as a bioactive ingredient in coating fresh fruits and vegetables. This research article outlines the potential food processing applications of clove essential oil. The chemical structures of components, bioactive properties, and medicinal potential of clove essential oil, including phytochemical importance in food, have also been thoroughly addressed.

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“…Eugenol has shown potential anticancer activity against colon, gastric, breast, prostate, melanoma, leukemia, or skin cancer [14]. Eugenol inhibits tumor proliferation and formation, increases the reactive oxygen species (ROS), generates apoptosis, and has a genotoxic effect in different cancer cells [14,[20][21][22].…”

Section: Ceo Compositionmentioning

confidence: 99%

Clove Essential Oil (<em>Syzygium aromaticum L. Myrtaceae</em>): Extraction, Chemical Composition, Food Applications and Essential Bioactivities for Human Health

Haro-González¹,

Castillo-Herrera²,

Martínez-Velázquez³

et al. 2021

Preprint

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Clove (Syzygium aromaticum L. Myrtaceae) is an aromatic plant widely cultivated in tropical and subtropical countries, rich in volatile compounds and antioxidants such as eugenol, β-caryophyllene, and α-humulene. Clove essential oil has received considerable interest due to its wide application in the perfumery, cosmetic, health, medical, flavoring, and food industries. Clove essential oil has relevant biological activities to human health, including antimicrobial, antioxidant, and insecticide. This review describes the effect of the extraction method (hydrodistillation, steam distillation, ultrasound-assisted extraction, microwave-assisted extraction, cold pressing, and supercritical fluid extraction) on the chemical composition of essential oil and its correlation with their biological activities. Likewise, are summarized the main compounds and their reported biological activities. Furthermore, the main applications in clove essential oil in the food industry are presented. Finally, this review presents the new biological activities such as anti-inflammatory, analgesic, anesthetic, antinociceptive and anticancer, which are beneficial for human health. This review aims to compile the effect of different methods of extracting clove essential oil on chemical composition, food applications, as well as a current description of biological activities of interest to human health. Biological activities have increased interest in research into this essential oil and its future applications in the food or pharmaceutical industry.

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Phenylpropanoids, Eugenol Scaffold, and Its Derivatives as Anticancer

Cited by 16 publications

References 40 publications

Clove Essential Oil (Syzygium aromaticum L. Myrtaceae): Extraction, Chemical Composition, Food Applications, and Essential Bioactivity for Human Health

Clove Essential Oil (Syzygium aromaticum L. Myrtaceae): Extraction, Chemical Composition, Food Applications, and Essential Bioactivity for Human Health

Studies Studies on the phytochemicals of clove and their biological activities

Clove Essential Oil (<em>Syzygium aromaticum L. Myrtaceae</em>): Extraction, Chemical Composition, Food Applications and Essential Bioactivities for Human Health

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