Phillipsins A and B from Zingiber phillippsii Mood &amp; Theilade in Borneo

Kamada, Takashi; Kulip, Julius; Tani, Kazuki; Phan, Chin-Soon; Hatai, Kishio; Vairappan, Charles Santhanaraju

doi:10.25135/rnp.33.17.09.145

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…Ginger (Zingiber officinale Roscoe), a popular spice with aromatic and pungent components, is also utilized in traditional medicine for its healing properties of various gastrointestinal diseases, metabolic diseases, rheumatism, arthritis, pain, and muscle discomfort [1][2][3]. Moreover, numerous studies have reported that ginger exhibits antibacterial, antifungal, and anticancer properties [4][5][6]. Ginger rhizome is widely cultivated as an important economic crop.…”

Section: Introductionmentioning

confidence: 99%

Genomic, Antimicrobial, and Aphicidal Traits of Bacillus velezensis ATR2, and Its Biocontrol Potential against Ginger Rhizome Rot Disease Caused by Bacillus pumilus

Liang

Deng

et al. 2021

Microorganisms

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Ginger rhizome rot disease, caused by the pathogen Bacilluspumilus GR8, could result in severe rot of ginger rhizomes and heavily threaten ginger production. In this study, we identified and characterized a new Bacillus velezensis strain, designated ATR2. Genome analysis revealed B. velezensis ATR2 harbored a series of genes closely related to promoting plant growth and triggering plant immunity. Meanwhile, ten gene clusters involved in the biosynthesis of various secondary metabolites (surfactin, bacillomycin, fengycin, bacillibactin, bacilysin, difficidin, macrolactin, bacillaene, plantazolicin, and amylocyclicin) and two clusters encoding a putative lipopeptide and a putative phosphonate which might be explored as novel bioactive compounds were also present in the ATR2 genome. Moreover, B. velezensis ATR2 showed excellent antagonistic activities against multiple plant pathogenic bacteria, plant pathogenic fungi, human pathogenic bacteria, and human pathogenic fungus. B. velezensis ATR2 was also efficacious in control of aphids. The antagonistic compound from B. velezensis ATR2 against B.pumilus GR8 was purified and identified as bacillomycin D. In addition, B. velezensis ATR2 exhibited excellent biocontrol efficacy against ginger rhizome rot disease on ginger slices. These findings showed the potential of further applications of B. velezensis ATR2 as a biocontrol agent in agricultural diseases and pests management.

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Section: Introductionmentioning

confidence: 99%

Genomic, Antimicrobial, and Aphicidal Traits of Bacillus velezensis ATR2, and Its Biocontrol Potential against Ginger Rhizome Rot Disease Caused by Bacillus pumilus

Liang

Deng

et al. 2021

Microorganisms

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“…The minimum inhibitory concentration (MIC) of the fungistatic on hyphae was performed by incorporating the pure compound solutions (12.5, 25.0, 50.0, 100.0 μg/mL) onto PYGS agar in a petri dish followed by inoculation of six tested fungal strains [21][22][23]. The MIC was determined visually as the lowest concentration showing no hyphal growth after they were incubated at 25 °C for 7 days.…”

Section: Antifungal Assaymentioning

confidence: 99%

A New Epi-neoverrucosane-type Diterpenoid from the Liverwort Pleurozia subinflata in Borneo

Kamada

Johanis

et al. 2020

Nat. Prod. Bioprospect.

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New bioactive 13-epi-neoverrucosane diterpenoid, 5β-acetoxy-13-epi-neoverrucosanic acid (1) along with three known secondary metabolites, 13-epi-neoverrucosan-5β-ol (2), chelodane (3) and (E)-β-farnesene (4) were isolated from the MeOH extract of east Malaysia's liverwort Pleurozia subinflata. The chemical structure of new compound was elucidated by the analyses of its spectroscopic data (FTIR, NMR and HR-ESI-MS). These epi-neoverrucosane-type compounds seem to be notable chemosystematic markers for P. subinflata in Borneo. Compound 3 was widespread in marine sponges however this is the first record for 3 to be found in liverwort. These metabolites were tested for their antifungal potentials against selected fungi from the marine environment. Compound 1 exhibited effective antifungal activity against Lagenidium thermophilum.

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“…The procedure was modified from known method [15,16]. The MIC was determined visually as the lowest concentration showing no hyphal growth when they were incubated at 25 °C for 7 days.…”

Section: Antifungal Bioassaymentioning

confidence: 99%

Leucoxenols A and B, two new phenolics from Bornean medicinal plant Syzygium leucoxylon

Shamsudin

Phan

Kulip

et al. 2018

Journal of Asian Natural Products Research

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The medicinal plant, Syzygium leucoxylon or commonly known as Obah found in North Borneo was considered as traditional medicine by local committee. Two new phenolics, leucoxenols A (1) and B (2) were isolated and identified as major secondary metabolites from the leaves of S. leucoxylon. Their chemical structures were elucidated based on spectroscopic data such as NMR and HRESIMS. Furthermore, these compounds were active against selected strains of fungi.

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Phillipsins A and B from Zingiber phillippsii Mood & Theilade in Borneo

Cited by 4 publications

References 11 publications

Genomic, Antimicrobial, and Aphicidal Traits of Bacillus velezensis ATR2, and Its Biocontrol Potential against Ginger Rhizome Rot Disease Caused by Bacillus pumilus

Genomic, Antimicrobial, and Aphicidal Traits of Bacillus velezensis ATR2, and Its Biocontrol Potential against Ginger Rhizome Rot Disease Caused by Bacillus pumilus

A New Epi-neoverrucosane-type Diterpenoid from the Liverwort Pleurozia subinflata in Borneo

Leucoxenols A and B, two new phenolics from Bornean medicinal plant Syzygium leucoxylon

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