Phloretin either alone or in combination with duloxetine alleviates the STZ-induced diabetic neuropathy in rats

Balaha, Mohamed; Kandeel, Samah; Kabel, Ahmed M.

doi:10.1016/j.biopha.2018.02.135

Cited by 27 publications

(14 citation statements)

References 58 publications

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“…Deguelin also ameliorates diabetic neuropathy, attenuated oxidative stress and neuroinflammation through the activation of NRF2 pathway, and partially restored the conduction velocities of neurons in diabetic rats by increasing (Na + -K + ) ATPase activity [94]. A similar neuroprotective effect against oxidative stress and inflammation was reported for phloretin, which either alone or in combination with the anti-neuropathic agent duloxetine promoted nerve fiber regeneration in STZ-induced diabetic rats [95].…”

Section: Diabetic Neuropathysupporting

confidence: 52%

The Coming Age of Flavonoids in the Treatment of Diabetic Complications

Caro-Ordieres

Marín-Royo

Opazo-Ríos

et al. 2020

JCM

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Diabetes mellitus (DM), and its micro and macrovascular complications, is one of the biggest challenges for world public health. Despite overall improvement in prevention, diagnosis and treatment, its incidence is expected to continue increasing over the next years. Nowadays, finding therapies to prevent or retard the progression of diabetic complications remains an unmet need due to the complexity of mechanisms involved, which include inflammation, oxidative stress and angiogenesis, among others. Flavonoids are natural antioxidant compounds that have been shown to possess anti-diabetic properties. Moreover, increasing scientific evidence has demonstrated their potential anti-inflammatory and anti-oxidant effects. Consequently, the use of these compounds as anti-diabetic drugs has generated growing interest, as is reflected in the numerous in vitro and in vivo studies related to this field. Therefore, the aim of this review is to assess the recent pre-clinical and clinical research about the potential effect of flavonoids in the amelioration of diabetic complications. In brief, we provide updated information concerning the discrepancy between the numerous experimental studies supporting the efficacy of flavonoids on diabetic complications and the lack of appropriate and well-designed clinical trials. Due to the well-described beneficial effects on different mechanisms involved in diabetic complications, the excellent tolerability and low cost, future randomized controlled studies with compounds that have adequate bioavailability should be evaluated as add-on therapy on well-established anti-diabetic drugs.

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Section: Diabetic Neuropathysupporting

confidence: 52%

The Coming Age of Flavonoids in the Treatment of Diabetic Complications

Caro-Ordieres

Marín-Royo

Opazo-Ríos

et al. 2020

JCM

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“…The highest content of phloretin was found in HR (309.96±20.32 μg/g), followed by NT (90.54±2.13 μg/g), and the similar contents of phloretins (53.37±0.79, 49.68±0.71 μg/g) were found in LR and RC, respectively. Previous studies indicated that phloretin existed primarily in the peel and root peel of apples and pears, and it could reduce excessive mucus secretion and airway inflammation, as well as diabetic neuropathy …”

Section: Resultsmentioning

confidence: 99%

A Comparative Study on Polyphenolic Composition of Berries from the Tibetan Plateau by UPLC‐Q‐Orbitrap MS System

Jia

Zhang

et al. 2020

Chemistry & Biodiversity

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Five traditional medicinal food from the Tibetan plateau including Nitraria tangutorum Bobrov (NT), Hippophae rhamnoides L. (HR), Lycium ruthenicum Murray (LR), Lycium barbarum L. (LB) and Rubus corchorifolius L.f. (RC) are rich in phenolic compounds. However, the detailed studies about the phenolic compounds remain scarce. Therefore, we established a rapid method for the simultaneous identification and quantification of the phenolic compounds from berries via Ultra Performance Liquid Chromatography-Quadruple-Orbitrap MS system (UPLC-Q-Orbitrap MS). This method was verified from many aspects including detection limit, quantification limit, precision, repeatability, stability, average recovery rate and recovery range, and then was used to analyze the phenolic compounds in these five species of berries. Finally, a total of 21 phenolic compounds were directly identified by comparing the retention time and exact mass, of which 14 compounds were identified by us for the first time in berries from the Tibetan plateau, including one flavonoid aglycone (myricetin), 11 phenolic acids (gallic acid, protocatechuate, chlorogenic acid, vanillic acid, caffeic acid, syringic acid, p-coumaric acid, ferulic acid, 2-hydroxybenzeneacetic acid and ellagic acid), one flavanol (catechin) and one dihydrochalcone flavonoid (phloretin). Quantitative results showed that rutin, myricetin, quercetin and kaempferol were the main flavonoids. Moreover, a variety of phenolic acid compounds were also detected in most of the berries from the Tibetan plateau. Among these compounds, the contents of protocatechuate and chlorogenic acid were high, and high levels of catechin and phloretin were also detected in these plateau berries.

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“… 3 The development of DPN is largely influenced by low blood flow and hyperglycemia, as such maintaining strict glycaemic control have been proposed as a viable option in the prevention or treatment of DPN. 10 , 22 …”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Antinociceptive Effects of Boesenbergia rotunda Polyphenol Extract in Diabetic Peripheral Neuropathic Rats

Wang¹,

Wen

Olatunji³

2022

JPR

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Introduction Diabetic peripheral neuropathy (DPN) is still one of the most prevailing complication of diabetes and it affects a huge diabetic population. Boesenbergia rotunda is a ginger species that has both culinary and medicinal applications. Recent studies have revealed that B. rotunda has potential applications in diabetes, pain and inflammatory related disorders. As such this study investigated the potential of B. rotunda extract (EBR) in attenuating DPN in rats. Methods DPN was induced in male Sprague Dawley rats using a combination of 30% fructose solution and streptozotocin (40 mg/kg). Afterwards diabetic rats were treated with EBR (100 and 400 mg/kg) for 5 weeks. DPN was assessed using thermal hyperalgesia, cold and mechanical allodynia and rotarod test, while nociceptive responses were assessed by formalin and acetic acid test. In addition, serum proinflammatory cytokine levels were determined using ELISA kits. Results EBR displayed hypoglycemic effect by significantly reducing the blood glucose concentration of treated diabetic rats, while simultaneously alleviating the reduced body weight. Furthermore, EBR markedly alleviated thermal hyperalgesia, cold and mechanical allodynic responses as well as ameliorated motor coordination in the treated diabetic rats. In addition, EBR significantly reduced nociceptive responses in the formalin and acetic acid test, as well as decreased serum levels of proinflammatory cytokines (TNF-α and IL-1β). Conclusion The results suggested that EBR exerted anti-inflammatory and anti-nociceptive effects, thus alleviating diabetic painful neuropathy.

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Phloretin either alone or in combination with duloxetine alleviates the STZ-induced diabetic neuropathy in rats

Cited by 27 publications

References 58 publications

The Coming Age of Flavonoids in the Treatment of Diabetic Complications

The Coming Age of Flavonoids in the Treatment of Diabetic Complications

A Comparative Study on Polyphenolic Composition of Berries from the Tibetan Plateau by UPLC‐Q‐Orbitrap MS System

Anti-Inflammatory and Antinociceptive Effects of Boesenbergia rotunda Polyphenol Extract in Diabetic Peripheral Neuropathic Rats

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