Abstract:In investigations with rats, we have shown that a low concentration of oral PPC (50 mg/kg b.w.) cannot protect the luminal mucosa membrane from being injured by the enterotoxic action of 5-FU/FA.
The beta-glucuronidase inhibitor SAL is able to significantly reduce CPT-11-induced mucosal damage in the small intestine of rats. This observation might soon have a clinical impact for the treatment of patients with CPT-11.
The beta-glucuronidase inhibitor SAL is able to significantly reduce CPT-11-induced mucosal damage in the small intestine of rats. This observation might soon have a clinical impact for the treatment of patients with CPT-11.
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