Phosphatidylserine for the Athlete

Carter, Jeremy; Greenwood, Mike

doi:10.1519/ssc.0000000000000112

Cited by 3 publications

(5 citation statements)

References 35 publications

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“…One drink that is used during competition and in practice by the members of several professional LoL teams is AI Reload (Reload). Active ingredients in Reload with the potential to affect cognition and/or gaming performance include caffeine and L-theanine (alone and in combination) [12,13,14], phosphatidylserine [15], Nicotinamide Adenine Dinucleotide [in the reduced form as NADH] [16], alpha-glycerylphosphorylcholine (alpha-GPC) [17], and L-Carnitine [18], though studies using this supplement have yet to be performed.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Energy Drink Consumption on Cognitive and Physical Performance in Elite League of Legends Players

Thomas

Rothschild

Earnest

et al. 2019

Sports

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To examine the cognitive and physical changes associated with consuming an energy drink concurrent to video gaming, we examined a convenience sample of nine elite League of Legends (LoL) e-sport players (21 ± 2 y, BMI 25.6 ± 3.4 kg/m2) consuming an energy drink (ReloadTM) or placebo (Placebo) in a randomized, double-blind, placebo-controlled cross-over trial. Participants completed the same test battery prior to treatment consumption and after playing each of three competitive LoL games. Primary outcomes included measures of attention (Erikson Flanker Test), reaction time (Go/No-Go test) and working memory (n-back test). Secondary outcomes examined fatigue (hand grip strength and finger tap speed). Statistical analysis was performed by repeated-measures analysis of variance (RM-ANOVA) and reported as the mean (standard deviation [SD]) or mean change (95% confidence interval [CI]). Participants reported sleeping 8.1 (1.2) h/night, playing LoL 10.3 (2.1) h/d, playing other video games 1.8 (2.8) h/d, and exercising 4.2 (1.7) times per week. Overall, we observed no significant time, group, or group-by-time interactions for any measured performance index with the exception of a significant improvement for the n-back test, where the Reload group demonstrated a significant within-group improvement: Reload [−171 ms (95% CI, −327.91, −14.09), p < 0.004], Placebo [−92 ms (95% CI, −213.63, 29.63)]. However, no between-group differences were noted (38.50 ms, 95% CI, −141.89, 64.89, p = 0.803). Our findings suggest that elite eSport athletes do not demonstrate a mental or physical improvement in performance relative to the treatment supplement or indices measured in this study.

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Section: Introductionmentioning

confidence: 99%

The Effects of Energy Drink Consumption on Cognitive and Physical Performance in Elite League of Legends Players

Thomas

Rothschild

Earnest

et al. 2019

Sports

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“…In addition, Starks et al [ 52 ] demonstrated that increased PSs are effective in combating exercise-induced stress and preventing physiological deterioration. In general, PSs act on human recovery and performance, also improving mood, immunity, decision-making and accuracy [ 53 ]. Other metabolites such as PCs and PEs are the most abundant glycerophospholipids in the cell membrane.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, some PCs and PEs possibly indicate greater aerobic power of elite players, since the VO 2 max was considered one of the most powerful discriminators among male soccer players at different competitive levels [ 1 ]. In addition, other discriminating metabolites can bring some benefits, such as potentiation of the recovery process, increased mood, immunity, decision making and accuracy, and improved exercise capacity with mitochondrial preservation and electron transport chain maintenance [ 52 , 53 , 56 , 57 , 58 , 59 ]. Thus, the metabolomic approach can contribute by offering additional data on the individual characterization of athletes, improving training programs, and consequently increasing the performance of players during competitions.…”

Section: Discussionmentioning

confidence: 99%

A Metabolomic Approach and Traditional Physical Assessments to Compare U22 Soccer Players According to Their Competitive Level

Cruz

Santos

Rasteiro

et al. 2022

Biology

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The purpose of this study was to use traditional physical assessments combined with a metabolomic approach to compare the anthropometric, physical fitness level, and serum fasting metabolic profile among U22 soccer players at different competitive levels. In the experimental design, two teams of male U22 soccer were evaluated (non-elite = 20 athletes, competing in a regional division; elite = 16 athletes, competing in the first division of the national U22 youth league). Earlobe blood samples were collected, and metabolites were extracted after overnight fasting (12 h). Untargeted metabolomics through Liquid Chromatograph Mass Spectrometry (LC-MS) analysis and anthropometric evaluation were performed. Critical velocity was applied to determine aerobic (CV) and anaerobic (ARC) capacity. Height (non-elite = 174.4 ± 7.0 cm; elite = 176.5 ± 7.0 cm), body mass index (non-elite = 22.1 ± 2.4 kg/m2; elite = 21.9 ± 2.3 kg/m2), body mass (non-elite = 67.1 ± 8.8 kg; elite = 68.5 ± 10.1 kg), lean body mass (non-elite = 59.3 ± 7.1 kg; elite = 61.1 ± 7.9 kg), body fat (non-elite = 7.8 ± 2.4 kg; elite = 7.3 ± 2.4 kg), body fat percentage (non-elite = 11.4 ± 2.4%; elite = 10.5 ± 1.7%), hematocrit (non-elite = 50.2 ± 4.0%; elite = 51.0 ± 4.0%), CV (non-elite = 3.1 ± 0.4 m/s; elite = 3.0 ± 0.2 m/s), and ARC (non-elite = 129.6 ± 55.7 m; elite = 161.5 ± 61.0 m) showed no significant differences between the elite and non-elite teams, while the multivariate Partial Least Squares Discriminant Analysis (PLS-DA) model revealed a separation between the elite and non-elite athletes. Nineteen metabolites with importance for projection (VIP) >1.0 were annotated as belonging to the glycerolipid, sterol lipid, fatty acyl, flavonoid, and glycerophospholipid classes. Metabolites with a high relative abundance in the elite group were related in the literature to a better level of aerobic power, greater efficiency in the recovery process, and improvement of mood, immunity, decision making, and accuracy, in addition to acting in mitochondrial preservation and electron transport chain maintenance. In conclusion, although classical physical assessments were not able to distinguish the teams at different competitive levels, the metabolomics approach successfully indicated differences between the fasting metabolic profiles of elite and non-elite teams.

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“…In the pursuit of optimizing athletic performance, athletes and sports professionals continually explore various strategies to enhance physical capabilities, improve training adaptations, and hasten recovery. Among the wide array of supplements geared towards the athletic community, phosphatidylserine (PS) has emerged as a promising supplement with potential benefits for athletic performance [1] . As a naturally occurring phospholipid present in cell membranes, PS plays a crucial role in numerous physiological processes [2] .…”

Section: Introductionmentioning

confidence: 99%

“…These cognitive benefits have implications for athletes, as optimal cognitive function is essential for decision-making, focus, and reaction times during training and competition. It has been proposed that PS supplementation could enhance cell membrane integrity and fluidity, potentially influencing muscle fiber recruitment, force production, and power output during exercise [1] . The objective of this review is to offer an extensive assessment of the potential advantages and limitations of phosphatidylserine in enhancing various facets of athletic performance, including recovery, exercise capacity, and cognitive performance.…”

Section: Introductionmentioning

confidence: 99%

The effect of phosphatidylserine supplementation on athletic performance: A systematic review of randomized clinical trials

Welch,

Bashir,

Daniels

2023

J. Sports Sci. Nutr.

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This review aims to critically evaluate the existing evidence derived from randomized clinical trials to determine the effectiveness of phosphatidylserine in enhancing athletic performance. Extensive searches were conducted in databases including PubMed, ClinicalTrials.gov, Google Scholar, Embase, Web of Science, CINAHL, and Medline. Among the initially identified 538 articles with potential relevance, a thorough assessment of full-text articles was performed, resulting in the inclusion of seven studies that satisfied all predefined inclusion criteria. All studies were evaluated as having a low risk of bias. Five of the included studies reported statistically significant differences before and after intervention, thus providing support for the use of phosphatidylserine as a supplement to support athletic performance. However, despite these promising results obtained from clinical trials, the current evidence remains insufficient to firmly endorse the use of phosphatidylserine for its impact on athletic performance.

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Phosphatidylserine for the Athlete

Cited by 3 publications

References 35 publications

The Effects of Energy Drink Consumption on Cognitive and Physical Performance in Elite League of Legends Players

The Effects of Energy Drink Consumption on Cognitive and Physical Performance in Elite League of Legends Players

A Metabolomic Approach and Traditional Physical Assessments to Compare U22 Soccer Players According to Their Competitive Level

The effect of phosphatidylserine supplementation on athletic performance: A systematic review of randomized clinical trials

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