1998
DOI: 10.1164/ajrccm.157.2.9708012
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Phosphodiesterase Isozymes

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Cited by 611 publications
(133 citation statements)
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“…Because PDE4 isoforms show specific expression patterns (14,18,20), susceptibility of the ␤ 2 AR to control by PDE4 activity will depend very much on cell type. Indeed, the complexity of ␤ 2 AR signaling pathways is extended further by the occurrence of isoforms of various regulatory proteins involved.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Because PDE4 isoforms show specific expression patterns (14,18,20), susceptibility of the ␤ 2 AR to control by PDE4 activity will depend very much on cell type. Indeed, the complexity of ␤ 2 AR signaling pathways is extended further by the occurrence of isoforms of various regulatory proteins involved.…”
Section: Discussionmentioning
confidence: 99%
“…Because PDEs provide the sole route for degradation of cAMP in cells, these enzymes are poised to play a key role in controlling cAMP signaling (11)(12)(13)(14). Of these enzymes, the PDE4 cAMP-specific PDE family has attracted much interest recently because PDE4-selective inhibitors, of which rolipram is the archetype, have therapeutic potential in a wide range of disorders (15)(16)(17)(18). Four genes (PDE4A-PDE4D) encode Ͼ16 different PDE4 isoforms, each characterized by a unique N-terminal region and showing distinct regulatory properties and modes of intracellular targeting (12,14,19,20).…”
Section: T He Functions Of G Protein-coupled Receptors (7ms Ormentioning
confidence: 99%
“…This observation has important pharmacological implications. Because PDE4 inhibitors are being developed as anti-inflammatory agents for asthma, chronic obstructive pulmonary disease, and other inflammatory disorders, our data hold promise for specific inhibition of a single PDE4 gene product as a viable strategy for pharmacological intervention (36).…”
Section: Discussionmentioning
confidence: 99%
“…These protein kinases are responsible for the phosphorylation of a number of substrates, such as ion channels, contractile proteins and transcription factors. In this manner, PDEs regulate key cellular functions and have fundamental and pharmacological interest: they have been acknowledged as important drug targets for the treatment of disparate diseases, such as congestive heart disease, depression, asthma, inflammation, and erectile dysfunction (14)(15)(16)(17).…”
mentioning
confidence: 99%