2022
DOI: 10.21203/rs.3.rs-1191933/v1
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Phosphoglucomutase 1 Contributes to Optimal Cyst Development in Toxoplasma Gondii

Abstract: Objective: Toxoplasma gondii is a ubiquitous parasite of medical and veterinary importance; however, there exists no cure for chronic toxoplasmosis. Metabolic enzymes required for the production and maintenance of tissue cysts represent promising targets for novel therapies. Here, we use reverse genetics to investigate the role of Toxoplasma phosphoglucomutase 1, PGM1, in Toxoplasma growth and cystogenesis.Results: We found that disruption of pgm1 did not significantly affect Toxoplasma intracellular growth an… Show more

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