Phosphoglyceride Metabolism

Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry-Based Metabolomics Reveals Metabolic Alterations in the Mouse Cerebellum During Toxoplasma gondii Infection

“…Two metabolites (2-lysophosphatidylcholine and lecithin) were altered at all three time points. 2-Lysophosphatidylcholine plays a role in phospholipid metabolism and in maintaining the integrity of the cell membrane ( van den Bosch, 1974 ). A previous report showed that the production of 2-lysophosphatidylcholine, which activates T lymphocytes, is triggered by antigen stimulation, and that 2-lysophosphatidylcholine production is time dependent ( Asaoka et al, 1992 ).…”

Protective Effect of Ethanolamine on Hepatic Preneoplastic Alterations Induced by the Administration of <i>N</i>-Nitrosodiethylamine in Rats

“…In most cells, Etn is phosphorylated, after which it combines with 1,2-diacylglycerol to form PE. Synthesized PE is integrated into membranes [1] [2] [3] [4]. In hepatocytes, a second pathway for synthesizing phosphatidylcholine (PC) in addition to the major pathway involving choline combining with 1,2-diacylglycerol exists; specifically, three methyl molecules provided from S-adenosylmethionine are added to the Etn moiety in PE to generate PC [5].…”