Phospholipase A Activation Following Extracorporeal Circulation and its Blockade by Procaine

Olthoff, D; Kunze, D; Rüstow, Bernd

doi:10.1055/s-2007-1021985

Cited by 8 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Procaine also inhibits the activation of the enzyme phospholipase A, which has destructive properties on the cell membrane. This mechanism may be involved in the antiarrhythmic action of the drug and constitutes a potential for metabolic postischemic protection (7). Procaine is an ester anesthetic, metabolized in the plasma by the enzyme acetylcholinesterase (AChE).…”

Section: Discussionmentioning

confidence: 99%

Cold Heparinized Lactated Ringers With Procaine (HeLP) Preservation Fluid in 266 Living Donor Kidney Transplantations

et al. 2007

View full text Add to dashboard Cite

Since the 1960s simple inexpensive cold lactated Ringers with additives has been used for short-term cold preservation of kidneys from living donors. We performed 266 living donor kidney transplantations from January 22, 2003 to October 30, 2006. Donor allografts were recovered laparoscopically and flushed with cold heparin, lactated Ringer's and procaine (HeLP) solution. Warm and cold ischemic times were typically <45 min and <90 min, respectively. The mean follow up was 21.6+/-12.2 months. There was no delayed graft function. Actuarial 1-year patient and graft survival were 98.6% and 98.1%, respectively. The creatinine at 1 year was 1.46+/-0.51 mg/dL. The cumulative incidences of acute cellular rejection at 6, 12, 18, and 24 months were 3.0%, 7.1%, 10.2%, and 11.7%. There were no identifiable side effects attributed to the HeLP solution. This study documents the effectiveness of cold HeLP as a flushing and short-term preservation fluid for living donor kidney transplantation with excellent results and significant cost benefit because of its low cost.

show abstract

Section: Discussionmentioning

confidence: 99%

Cold Heparinized Lactated Ringers With Procaine (HeLP) Preservation Fluid in 266 Living Donor Kidney Transplantations

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Procaine exerts its effects by blocking the sodium inflow through the cell membrane [20], and by inhibiting the enzyme phospholypase A activation [21], which has destructive properties to the cell membrane. These mechanisms can be involved with the arrhythmic action of this drug and become a myocardial protection factor in the reperfusion and ischemia period.…”

Section: -Electromicrography Of Cardiac Muscle -M-mitochondria; G-glymentioning

confidence: 99%

Análise ultra-estrutural do miocárdio usando solução cardioplégica cristalóide com e sem procaína em pacientes submetidos à troca valvar aórtica

Dussin¹,

Moura²,

Gib³

et al. 2008

Rev Bras Cir Cardiovasc

View full text Add to dashboard Cite

Análise ultra-estrutural do miocárdio usando solução cardioplégica cristalóide com e sem procaína em pacientes submetidos à troca valvar aórtica Ultrastructural study of the myocardium using cardioplegic crystalloid solution with and without procaine in patients undergoing aortic valve replacement Abstract Objective: The aim of this study was to assess whether the presence of procaine in crystalloid cardioplegic solution increases myocardial protection at the ultra structural level.Methods: Eighteen patients that underwent aortic valve replacement in the Hospital de Clínicas de Porto Alegre over a 10-month period were studied. They were randomly allocated into two groups: group A -eight patients receiving cardioplegia without procaine; group B -ten patients receiving cardioplegia with procaine. Myocardial biopsies were performed in three different periods: 1st -before ischemic arrest, 2nd -at the end of ischemic arrest, and 3rd -15 minutes after reperfusion.Results: The ultra structural analysis comparing the groups in the three moments did not show any statistically significant difference. The mean score in group A at moment I, II and III was 0.1 ± 0.2; 0.4 ± 0.3; 0.4 ± 0.4, and group B 0.2 ± 0.2; 0.4 ± 0.3; 0.7 ± 0.2. Comparative analysis of CK-MB was similar. The spontaneous return to sinus rhythm after aortic declamping in group B occurred in 70% and in group A 12.5% (p=0.024).Conclusion: Both cardioplegic solutions tested were equally effective in myocardial preservation, and we could not demonstrate at the ultrastructural level any benefit when procaine was added. The spontaneous return to sinus rhythm after aortic declamping was significantly greater when procaine was added. 390DUSSIN, LH ET AL -Ultrastructural study of the myocardium using cardioplegic crystalloid solution with and without procaine in patients undergoing aortic valve replacement Bras Cir Cardiovasc 2008; 23(3): 389-395 Rev

show abstract

Procaine Is Effective for Minimizing Postischemic Ventricular Fibrillation in Cardiac Surgery

Sellevold

Berg

Levang

1995

Anesthesia & Analgesia

View full text Add to dashboard Cite

Procaine hydrochloride was added to cardioplegia and studied for its efficacy in stabilizing the postischemic rhythm after aortic declamping in cardiac surgery. Fifty-six patients scheduled for coronary artery bypass grafting (CABG), were included in a randomized, double-blind study. The patients were anesthetized with isoflurane, low-dose fentanyl, diazepam, and pancuronium. In the study group (28 patients), St. Thomas' Hospital cardioplegic solution II (Plegisol) was prepared with 1 mM procaine. The control group (28 patients) was given the same cardioplegia with saline. Ventricular fibrillation (VF) occurring after declamping was treated with direct current (DC) shock (8-12-12-20 J). There were no significant differences with regard to demographic properties or anesthesiologic and surgical treatment. Two patients (7%) in the procaine group required DC shock for VF, compared to 28 (100%) in the control group (P < 0.001). The amount of lidocaine (mean +/- SEM) given for resistant dysrhythmias was 3.6 mg +/- 3.6 in the procaine group compared to 35.7 mg +/- 9.2 in the control group (P < 0.002). One patient in each group required temporary pacing. The number of synchronized DC shocks for conversion of atrial fibrillation was lower in the procaine group (P < 0.05). The enzyme release the first day after surgery was lower in the procaine group (P < 0.05). Procaine (1 mM) in cardioplegia stabilizes the postischemic rhythm in CABG surgery in humans without any observed adverse effects.

show abstract

Phospholipase A Activation Following Extracorporeal Circulation and its Blockade by Procaine

Cited by 8 publications

References 4 publications

Cold Heparinized Lactated Ringers With Procaine (HeLP) Preservation Fluid in 266 Living Donor Kidney Transplantations

Cold Heparinized Lactated Ringers With Procaine (HeLP) Preservation Fluid in 266 Living Donor Kidney Transplantations

Análise ultra-estrutural do miocárdio usando solução cardioplégica cristalóide com e sem procaína em pacientes submetidos à troca valvar aórtica

Procaine Is Effective for Minimizing Postischemic Ventricular Fibrillation in Cardiac Surgery

Contact Info

Product

Resources

About