Phospholipid content, expression and support of thrombin generation of neonatal platelets

Bernhard, Heike; Rosenkranz, A.; Petritsch, M.; Köfeler, Harald; Rehak, Thomas; Novak, M. John; Muntean, W.

doi:10.1111/j.1651-2227.2008.01075.x

Cited by 22 publications

(17 citation statements)

References 26 publications

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“…Currently, the neonatal platelet is characterized as hypo -functional as compared to the adult platelet despite evidence of more efficient global primary hemostasis in neonates (5). In this review, the literature regarding neonatal platelet function will be reviewed and synthesized in order to more clearly define the neonatal platelet functional phenotype and its contribution to the newborn’s hemostatic system (Table 1(6-18)).…”

Section: Introductionmentioning

confidence: 99%

“…

Phosphatidylserine (PS) exposure: Annexin V, which binds PS with high affinity, can be used to characterize the procoagulant phenotype of activated platelets. Analysis of PS exposure through measurement of Annexin V binding via flow cytometry has shown that the procoagulant phenotype is similar for both cord blood-derived platelets and adult platelets following stimulation with thrombin (17,18). Along these lines, phospholipid content of adult and cord blood platelets has also been reported to be similar (17,18).

…”

Section: Introductionmentioning

confidence: 99%

“…Analysis of PS exposure through measurement of Annexin V binding via flow cytometry has shown that the procoagulant phenotype is similar for both cord blood-derived platelets and adult platelets following stimulation with thrombin (17,18). Along these lines, phospholipid content of adult and cord blood platelets has also been reported to be similar (17,18). The procoagulant phenotype of peripheral blood-derived neonatal platelets has yet to be defined.…”

Section: Introductionmentioning

confidence: 99%

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Neonatal platelets: mediators of primary hemostasis in the developing hemostatic system

2014

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The human hemostatic system is developmentally regulated, resulting in qualitative and quantitative differences in the mediators of primary and secondary hemostasis as well as fibrinolysis in neonates and infants. Although gestational and age related differences in coagulation factor levels occur, the existence of a unique neonatal platelet phenotype remains controversial. Complicated by difficulties in obtaining adequate neonatal blood volumes with which to perform functional assays, ambiguity surrounds the characterization of neonatal platelets. Thus, much of the current knowledge of neonatal platelet function has been based on studies from cord blood samples. Studies suggest that cord blood-derived platelets, as a surrogate for neonatal platelets, are hypo-functional when compared to adult platelets. This relative platelet dysfunction combined with a propensity toward thrombocytopenia in the Neonatal Intensive Care Unit population, creates a clinical conundrum regarding the appropriate administration of platelet transfusions. This review provides an appraisal of the distinct functional phenotype of neonatal platelets. Neonatal platelet transfusion practices and the impact of the relatively hypo-functional neonatal platelet on those practices will be considered.

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Section: Introductionmentioning

confidence: 99%

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neonatal platelets: mediators of primary hemostasis in the developing hemostatic system

2014

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“…The phospholipid content and baseline exposure of platelet surface phosphatidylserine is comparable in adults and newborns [65,66]. However, more platelet microparticles are generated and more phosphatidylserine molecules are exposed in the term and preterm platelets when thrombin or calcium ionophores were used as activators [67].…”

Section: Newborn Plateletsmentioning

confidence: 99%

Platelets in the Newborn

Esiaba¹,

Mousselli²,

Faison³

et al. 2019

Neonatal Medicine

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Platelets were first described in the mid-nineteenth century. Since then, their roles were identified in hemostasis and thrombosis, inflammation, leukocyte interactions, angiogenesis, and cancer growth. But there is little information about such platelet functions in the newborn. Several studies highlighted some platelet differences between newborns and adults. Yet, in spite of these differences, healthy newborns appear to be adequately protected. A number of factors, however, were reported to negatively affect neonatal platelets. These include maternal hypertensive disorders or infections, neonatal asphyxia or respiratory distress, therapies such as ampicillin or indomethacin, and treatment modalities such as ventilators, nitric oxide, or extracorporeal membrane oxygenation (ECMO). Their effects on newborn platelets are usually transitory, lasting from several hours to a few days or weeks. If these effects are well characterized, they could serve as reporters for diagnosis and monitoring during therapy. Careful studies of neonatal platelets are needed to improve the understanding of basic physiology and pathophysiology in this cohort and to identify possible targets for intervention and therapy.

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“…To estimate bleeding tendency, is still a diagnostic challenge, particularly for children [8,10,18] . An increasing body of evidence shows that the thrombogram assay as described by Hemker [2,11] may be a useful tool in the diagnosis of hyper-and hypocoagulability . The thrombogram (s. • ▶ Fig.…”

Section: Introduction ▼mentioning

confidence: 99%

The Effect of Valproate Therapy on Thrombin Generation Determined by Calibrated Automated Thrombography

Topf

Lischetzki²,

Trollmann³

et al. 2011

Klin Padiatr

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Phospholipid content, expression and support of thrombin generation of neonatal platelets

Abstract: Our results do not provide any evidence that a different phospholipid-expression of neonatal platelets may alter TG in neonates.

Cited by 22 publications

References 26 publications

Neonatal platelets: mediators of primary hemostasis in the developing hemostatic system

Neonatal platelets: mediators of primary hemostasis in the developing hemostatic system

Platelets in the Newborn

The Effect of Valproate Therapy on Thrombin Generation Determined by Calibrated Automated Thrombography

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