Phosphonates, their complexes and bio-applications: A spectrum of surprising diversity

Physiologic Activity of Bisphosphonates – Recent Advances

“…Soon, these compounds had been found to act as strong metal ion complexones [2] with useful industrial and household applications, including detergents, water treatment agents, dispersants preventing re-disposition of insoluble inorganic matter and compounds avoiding the metal-catalyzed decomposition of hydrogen peroxide in bleaching formulations [3].…”

Synthetic Procedures Leading towards Aminobisphosphonates

“…Because this compound was previously prepared by acid hydrolysis of N-benzhydrylaminomethylenebisphosphonic acid [83,100], it may be that it is formed upon hydrolysis of N-aryl derivatives. The three-component reaction was applied to synthesize a large series of physiologically active compounds, in some cases of very complex chemical structures, including bone antiresorptive drug candidates [75][76][77][78][79][80][81][82]; bone imaging [83,84], antiprotozoal [85][86][87][88], antibacterial [72,[89][90][91][92], anti-HIV [93] and anti-inflammatory [94] agents; herbicides [95][96][97]; and complex ones for various metals [10,98].…”

“…This strong interest results from these compounds acting as strong inhibitors of bone resorption, with several representatives of this class already commercialized as drugs of choice for the treatment of osteoporosis, skeletal complications of malignancy, Paget's disease, multiple myeloma, hypercalcemia and fibrous dysplasia [2][3][4][5][6][7] Consequently, most of the papers are devoted to various clinical aspects of the anti-resorptive effects that bisphosphonates exert towards bone tissues; however, there is also a growing interest in their applications as anticancer and antibacterial agents [5][6][7]. Additionally, aminobisphosphonic acids have found important industrial applications, largely as inhibitors of scale formation and as corrosion inhibitors, actions which result from their ability to complex metal ions [8][9][10].…”

Diethyl boronobenzylphosphonates as substrates in Petasis reaction

“…[1][2][3][4][5] In addition, aminophosphonic acids and their derivatives are able to form complexes with a variety of metal ions. 6 These findings ensure that they still continue to attract wide interest.…”