Phosphoric Acid Functionalized Nanostructured Heterogeneous Catalyst for Multicomponent Synthesis of 2‐Amino‐4H‐chromene

Abstract

Functionalization of synthesized mesoporous MCM‐48 was performed using phosphoric acid via post synthesis modification method and characterized using different analytical techniques. The acidic character of the phosphoric acid modified material was enhanced compared to parent MCM‐48 as predicted from the Ammonia‐Temperature Programmed Desorption (NH3‐TPD) analysis. The catalytic activity of the synthesized materials was investigated for the synthesis of 2‐amino‐4H‐chromene via one pot three component reaction using aldehyde, malononitrile and dimedone using ethanol as solvent at 60 °C. Moderate to good yields of the desired products were obtained with substituted benzaldehyde under the optimized reaction condition. Moreover, reusability of the catalyst was also demonstrated upto five catalytic cycles with minimal loss in catalytic activity.

One‐pot Multicomponent Synthesis of Novel Chromene Derivatives Using New Organic Phosphate Salt Catalysts

“…Thus, from the viewpoint of synthetic chemists, these reactions contribute significantly to synthesizing heterocyclic compounds in organic chemistry. [1][2][3][4][5][6][7][8][9][10][11] Chromenes and pyrans are considerably important heterocyclic compounds attracting the attention of scientists due to their various significant biological effects, including anticancer, [12][13][14] antibacterial, [15,16] antioxidant, [17] antimycobacterial [18,19] and anti-epileptic [20] (Figure 1).…”