Phosphorodiamidate morpholino targeting the 5′ untranslated region of the ZIKV RNA inhibits virus replication

Popik, Waldemar; Khatua, Atanu K.; Hildreth, James E. K.; Lee, Benjamin; Alcendor, Donald J.

doi:10.1016/j.virol.2018.04.001

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Phosphorodiamidate morpholino targeting the 5′ untranslated region of the ZIKV RNA inhibits virus replication

Abstract: Morpholino DWK-1 targeting the ZIKV 5'-UTR effectively inhibits ZIKV replication and suppresses ZIKV-induced proinflammatory gene expression.

Cited by 5 publications

References 29 publications

The Medicinal Chemistry of Zika Virus

The Medicinal Chemistry of Zika Virus

Detection of unique Ebola virus oligonucleotides using fluorescently-labeled phosphorodiamidate morpholino oligonucleotide probe pairs

Development of the reverse genetics system for emerging atypical porcine pestivirus using in vitro and intracellular transcription systems

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