Phosphorous-containing flame retardant plasticizer based on Cassia fistula seed oil and their application in poly(vinyl chloride) films

Rajput, Chetan V.; Sastry, Nandhibatla V.; Chikhaliya, Navin P.

doi:10.1016/j.indcrop.2023.117120

Cited by 12 publications

(3 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Dpolarization functions on heavy atoms and p-polarization functions on hydrogen atoms were used. [81] All the ground states were confirmed by the absence of imaginary frequencies. To acquire and analyze the data and visualization, Gauss View ver.…”

Section: Antiproliferative Activitymentioning

confidence: 84%

Microwave‐induced one‐pot synthesis of 3‐imidazolyl indole clubbed 1,2,3‐triazole hybrids as antiproliferative agents and density functional theory study

Chudasama,

Rajput,

Patel

et al. 2023

Archiv der Pharmazie

Self Cite

View full text Add to dashboard Cite

Herein, we outline a highly efficient PEG‐4000‐mediated one‐pot three‐component reaction for the synthesis of 3‐imidazolyl indole clubbed 1,2,3‐triazole derivatives (5a–r) at up to 96% yield as antiproliferative agents. This three‐component protocol offers the advantages of an environmentally benign reaction, excellent yield, quick response time, and operational simplicity triggered by the copper catalyst under microwave irradiation. All the synthesized compounds were tested for antiproliferative activity against six human solid tumor cell lines, that is, A549 and SW1573 (nonsmall cell lung), HBL100 and T‐47D (breast), HeLa (cervix), and WiDr (colon). Among them, six compounds, 5g–j, 5m, and 5p, demonstrated effective antiproliferative action with GI50 values under 10 μM. Furthermore, density functional theory (DFT) calculations were performed for all the synthesized molecules through geometry optimizations, frontier molecular orbital approach, and molecular electrostatic potential (MESP). The theoretical DFT calculation was performed using the DFT/B3LYP/6‐31+G (d,p) basis set. Moreover, the biological reactivity of all the representative synthesized molecules was compared with the theoretically calculated quantum chemical descriptors and MESP 3D plots. We also investigated the drug‐likeness characteristic and absorption, distribution, metabolism, excretion, and toxicity (ADMET) prediction. In general, our approach enables environmentally friendly access to 3‐imidazolyl indole clubbed 1,2,3‐triazole derivatives as prospective antiproliferative agents.

show abstract

Section: Antiproliferative Activitymentioning

confidence: 84%

Microwave‐induced one‐pot synthesis of 3‐imidazolyl indole clubbed 1,2,3‐triazole hybrids as antiproliferative agents and density functional theory study

Chudasama,

Rajput,

Patel

et al. 2023

Archiv der Pharmazie

Self Cite

View full text Add to dashboard Cite

show abstract

“…The 1 H NMR titration study was performed to prove the binding mechanism of receptor 4 ba with Cu 2 + metal ions (Figure S74). Furthermore, to get more insight into the binding between the ligand 4 ba (NÀ H group of the pyrimidine ring) and Cu 2 + ions via electrostatic interaction, we performed the DFT calculations to determine various effective parameters such as HOMO-LUMO energies, dipole moment, and quantum chemical descriptors (QCDs) were obtained using different equations [36,37] (Table S2). The band gap value for the ligand 4 ba was found to be 4.38 eV whereas the 4 ba-Cu-4 ba complex exhibits a band gap of 2.56 eV.…”

Section: Binding Mechanism Of 4 Ba With Cu 2 +mentioning

confidence: 99%

Meglumine‐based Sustainable Three‐component Deep Eutectic Solvent Applicable for the Synthesis of Pyrazolo[5,1‐b]quinazoline‐3‐carboxylates as a Sensing Probe for Cu²⁺ Ions

Parekh,

Patel,

Chudasama

et al. 2024

Chemistry An Asian Journal

Self Cite

View full text Add to dashboard Cite

An unprecedented meglumine‐based three‐component deep eutectic solvent (3c‐DES) (MegPAc) was synthesized using meglumine, p‐toluenesulfonic acid (PTSA), and acetic acid as renewable, and non‐toxic solvent. The exploitation of the MegPAc as an eco‐friendly reaction media to construct a selective and sensitive small organic molecular sensing probe, namely, pyrazolo[5,1‐b]quinazoline‐3‐carboxylates (PQCs) was executed. Captivatingly, the MegPAc served the dual role as solvent and catalyst, and it delivered the title components with 69‐94% yields within 67‐150 minutes. Furthermore, a UV‐visible study unfolds the selective detection of Cu2+ ions with our synthetic probe 4ba and resulted in hypsochromic shifts due to electrostatic interactions. Additionally, 1H NMR titration study and density functional theory (DFT) calculations were performed to attest the binding mechanism of sensing probe 4ba and Cu2+ ions. Worthy of mention, this protocol unveils the efficacy of meglumine‐based 3c‐DES for the first time as a bio‐renewable system to synthesize the PQCs.

show abstract

“…To address these issues, researchers have begun to explore the development of biobased flame-retardant plasticizers as alternatives to conventional plasticizers and flame retardants. , These additives, derived from renewable resources, offer lower toxicity and enhanced biodegradability, aligning with the growing demand for green chemistry solutions. Besides, the development of biobased flame-retardant plasticizers not only contributes to reducing reliance on petrochemical resources but also mitigates the environmental impact of plastic products throughout their lifecycle.…”

Section: Introductionmentioning

confidence: 99%

Flame-Retardant Plasticizer Derived from Renewable Acids for Poly(Vinyl Chloride) Improved Toughness and Flame Retardancy

Hou,

Shan,

Cui

et al. 2024

ACS Appl. Polym. Mater.

View full text Add to dashboard Cite

Biobased plasticizers have gained significant attention for their potential to replace conventional petrochemical-based additives in the production of flexible poly(vinyl chloride) (PVC) products, offering an environmentally friendly alternative. However, the incorporation of biobased plasticizers can render PVC materials highly flammable and produce substantial smoke, posing significant safety and environmental concerns. To address these challenges, this study developed a biobased biodegradable flame-retardant plasticizer (PLRCL) synthesized from renewable acids, namely, ricinoleic acid, L-lactic acid, and levulinic acid, along with 9,10-dihydro-oxa-10-phosphaphenanthrene-10-oxide (DOPO). The innovation of this study lies in the successful synthesis of PLRCL and its integration into PVC films, which not only enhances the flame retardancy but also improves the toughness of the material. The PLRCL-endowed PVC films achieved a UL-94 V-0 grade and a significantly higher limited oxygen index of 37.9%, compared to the commercial plasticizer dioctyl phthalate plasticized PVC films. The pyrolysis of PLRCL was found to facilitate the formation of a complete and continuous char layer, thus improving the thermostability and fire resistance of the PVC films. This char layer acts as a protective barrier, suppressing the release of smoke and toxic gases during combustion, thereby improving the overall safety of the PVC materials. Mechanical testing revealed that the elongation at break and tensile strength of plasticized PVC films with 40 phr PLRCL reached 302.59% and 28.34 MPa, exhibiting outstanding flexibility. Meanwhile, the good volatilization and migration resistance of PLRCL endowed the long-term stability of PVC films. Besides, the loading of PLRCL could keep good optical transparency and improve the processability of the PVC products. Soil degradation experiments demonstrated that PLRCL is biotransformed by the microorganisms present in the soil into nontoxic and innocuous lipid molecules, highlighting the environmental benefits of PLRCL. In all, PLRCL is a promising green sustainable multifunctional plastic additive, offering a viable alternative to traditional petroleum-based plasticizers and providing insights into the design of sustainable flame-retardant plasticizers.

show abstract

Phosphorous-containing flame retardant plasticizer based on Cassia fistula seed oil and their application in poly(vinyl chloride) films

Cited by 12 publications

References 73 publications

Microwave‐induced one‐pot synthesis of 3‐imidazolyl indole clubbed 1,2,3‐triazole hybrids as antiproliferative agents and density functional theory study

Microwave‐induced one‐pot synthesis of 3‐imidazolyl indole clubbed 1,2,3‐triazole hybrids as antiproliferative agents and density functional theory study

Meglumine‐based Sustainable Three‐component Deep Eutectic Solvent Applicable for the Synthesis of Pyrazolo[5,1‐b]quinazoline‐3‐carboxylates as a Sensing Probe for Cu²⁺ Ions

Flame-Retardant Plasticizer Derived from Renewable Acids for Poly(Vinyl Chloride) Improved Toughness and Flame Retardancy

Contact Info

Product

Resources

About

Phosphorous-containing flame retardant plasticizer based on Cassia fistula seed oil and their application in poly(vinyl chloride) films

Cited by 12 publications

References 73 publications

Microwave‐induced one‐pot synthesis of 3‐imidazolyl indole clubbed 1,2,3‐triazole hybrids as antiproliferative agents and density functional theory study

Microwave‐induced one‐pot synthesis of 3‐imidazolyl indole clubbed 1,2,3‐triazole hybrids as antiproliferative agents and density functional theory study

Meglumine‐based Sustainable Three‐component Deep Eutectic Solvent Applicable for the Synthesis of Pyrazolo[5,1‐b]quinazoline‐3‐carboxylates as a Sensing Probe for Cu2+ Ions

Flame-Retardant Plasticizer Derived from Renewable Acids for Poly(Vinyl Chloride) Improved Toughness and Flame Retardancy

Contact Info

Product

Resources

About

Meglumine‐based Sustainable Three‐component Deep Eutectic Solvent Applicable for the Synthesis of Pyrazolo[5,1‐b]quinazoline‐3‐carboxylates as a Sensing Probe for Cu²⁺ Ions