Phosphorus-containing amino acids with a P–C bond in the side chain or a P–O, P–S or P–N bond: from synthesis to applications

Abstract

Strategies for the preparation of phosphorus-containing amino acids and their utility in the organic chemistry, physico-chemistry, agrochemistry, and pharmacology fields are reported.

Asymmetric Synthesis of Chiral Amino Carboxylic‐Phosphonic Acid Derivatives

“…Very recently, Rémond, Cavelier et al . summarized the synthesis of selected phosphorus‐containing α‐amino acids [20] . However, a comprehensive analysis on this vigorous subject, especially on the asymmetric transformations to chiral molecules, has no precedence.…”

Diversity‐Oriented Synthesis (DOS) of On‐DNA Peptidomimetics from Acid‐Derived Phosphonium Ylides

“…Incorporation of phosphorus into amino acids has been reported to generate phosphonium ylides or β‐keto phosphonates, and further transformations lead to a diverse set of α,β‐unsaturated molecules [7] …”

Fe3O4@glutamate MOF functionalized with Co nanoparticles anchored dicyandiamde: As a capable heterogeneous and reusable nanocatalyst in C–P cross‐coupling reaction

“…Over the past two decades, the formation of carbonphosphorus (C-P) bond has proved to be one of the most prominent strategies in preparing a diverse range of biologically active organophosphorus compounds in medicinal chemistry, coordination chemistry, organic synthesis, and catalysis. [1][2][3][4][5][6] In this context, much effort has been devoted to improving the new strategies for the generating the C-P bond. Hence, the C-P bond construction catalyzed with transition metals can be modified efficiently by decreasing impressive costs and extra materials, also increasing selectivity and functional group tolerance.…”