Phosphorus dendrimers functionalised with nitrogen ligands, for catalysis and biology

Caminade, Anne‐Marie; Majoral, Jean‐Pierre

doi:10.1039/c9dt01305a

Cited by 9 publications

(3 citation statements)

References 105 publications

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“…Multivalent interactions can be collectively much stronger than the corresponding monovalent interactions, in particular through multiple ligand-receptor interactions. Dendrimers, which are inherently multivalent species, are widely used in different fields of science and technology, such as catalysis [31], biomaterials [32,33], regenerative and cell biology [34][35][36][37], and nanomedicine [38][39][40][41].…”

Section: The Use Of Dendrimers For Biomedical Applications 21 Dendrim...mentioning

confidence: 99%

Dendrimer-Mediated Delivery of DNA and RNA Vaccines

et al. 2023

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DNA and RNA vaccines (nucleic acid-based vaccines) are a promising platform for vaccine development. The first mRNA vaccines (Moderna and Pfizer/BioNTech) were approved in 2020, and a DNA vaccine (Zydus Cadila, India), in 2021. They display unique benefits in the current COVID-19 pandemic. Nucleic acid-based vaccines have a number of advantages, such as safety, efficacy, and low cost. They are potentially faster to develop, cheaper to produce, and easier to store and transport. A crucial step in the technology of DNA or RNA vaccines is choosing an efficient delivery method. Nucleic acid delivery using liposomes is the most popular approach today, but this method has certain disadvantages. Therefore, studies are actively underway to develop various alternative delivery methods, among which synthetic cationic polymers such as dendrimers are very attractive. Dendrimers are three-dimensional nanostructures with a high degree of molecular homogeneity, adjustable size, multivalence, high surface functionality, and high aqueous solubility. The biosafety of some dendrimers has been evaluated in several clinical trials presented in this review. Due to these important and attractive properties, dendrimers are already being used to deliver a number of drugs and are being explored as promising carriers for nucleic acid-based vaccines. This review summarizes the literature data on the development of dendrimer-based delivery systems for DNA and mRNA vaccines.

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Section: The Use Of Dendrimers For Biomedical Applications 21 Dendrim...mentioning

confidence: 99%

Dendrimer-Mediated Delivery of DNA and RNA Vaccines

et al. 2023

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“…Among the phosphorus-containing dendrimers, those bearing iminopyridine (IP) terminal groups have good ability to coordinate Cu(II) [123]. As a result, some phosphorus multidentate dendrimers of generation Gn (n = 1 to 3) decorated with IP and coordinated to CuCl 2 moiety were developed and tested for antiproliferative activity against a panel of tumor cell lines.…”

Section: Dendrimersmentioning

confidence: 99%

Improvement in the Pharmacological Profile of Copper Biological Active Complexes by Their Incorporation into Organic or Inorganic Matrix

2020

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Every year, more Cu(II) complexes are proven to be biologically active species, but very few are developed as drugs or entered in clinical trials. This is due to their poor water solubility and lipophilicity, low stability as well as in vivo inactivation. The possibility to improve their pharmacological and/or oral administration profile by incorporation into inorganic or organic matrix was studied. Most of them are either physically encapsulated or conjugated to the matrix via a moiety able to coordinate Cu(II). As a result, a large variety of species were developed as delivery carriers. The organic carriers include liposomes, synthetic or natural polymers or dendrimers, while the inorganic ones are based on carbon nanotubes, hydrotalcite and silica. Some hybrid organic-inorganic materials based on alginate-carbonate, gold-PEG and magnetic mesoporous silica-Schiff base were also developed for this purpose.

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“…Dendrimers do not behave as conventional polymers and can exhibit specific properties due to the socalled "dendritic effect". [11][12][13][14] In particular, the properties of dendrimers can be different from the monomer ("multivalency effect") or different between generations ("generation effect"), leading to a wide variety of applications 2,15,16 including drug delivery/biological applications [17][18][19][20][21] and catalysis, [22][23][24][25] with many studies focusing on the PAMAM dendrimer. 26,27 Owing to their properties, dendrimers have been integrated into silica-based materials in a variety of ways to produce nanohybrid systems.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous organosilicas with thiol functionalised pores: multifunctional dendrimers as sacrificial building block and template

et al. 2022

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Phosphorus dendrimers functionalised with nitrogen ligands, for catalysis and biology

Abstract: Phosphorus dendrimers (dendrimers having one phosphorus atom at each branching point) possess versatile properties, depending on the type of their terminal functions.

Cited by 9 publications

References 105 publications

Dendrimer-Mediated Delivery of DNA and RNA Vaccines

Dendrimer-Mediated Delivery of DNA and RNA Vaccines

Improvement in the Pharmacological Profile of Copper Biological Active Complexes by Their Incorporation into Organic or Inorganic Matrix

Mesoporous organosilicas with thiol functionalised pores: multifunctional dendrimers as sacrificial building block and template

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